WormBase Tree Display for Gene: WBGene00004257
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| WBGene00004257 | Evidence | Person_evidence | WBPerson345 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | pxn-2 | Person_evidence | WBPerson345 | |||||
| Sequence_name | K09C8.5 | ||||||||
| Molecular_name | K09C8.5 | ||||||||
| K09C8.5.1 | |||||||||
| CE18882 | |||||||||
| Other_name | CELE_K09C8.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | pxn-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pxn | ||||||||
| Allele (91) | |||||||||
| Strain | WBStrain00050779 | ||||||||
| WBStrain00050789 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00004256 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00015841 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009897 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00011530 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019613 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022743 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016700 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019970 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00008627 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00017968 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pxn-2 encodes a member of the peroxidasin family of extracellular peroxidases containing several LLRs, two of four Ig domains and a heme peroxidase catalytic domain, PXN-2 is closely related to human PXDN and PXDNL (OMIM: 605158); PXN-2 function becomes critical soon after the twofold stage of epidermal elongation in embryos; pxn-2 mutants display defects in late stages of epidermal elongation, in muscle and epidermal muscle attachments, in vulval muscle attachment and in morphology of adult pharynx; PXN-2 supports a role in basement membrane function and in neuronal development, PXN-2 acts in selective axon guidance decisions but not essential for axon growth; PXN-2 inhibits adult axon regrowth after injury; PXN-1 acts antagonistically to PXN-2; PXN-2 expressed in differentiated epidermal cell throughout embryonic, larval and adult development, in vulval muscles and a few neurons, in longitudinal striations adjacent to the body wall muscle quadrant close to endogenous basement membrane components. | Curator_confirmed | WBPerson12884 | |||||
| Date_last_updated | 22 Jun 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable peroxidase activity. Involved in several processes, including embryonic body morphogenesis; muscle attachment; and regulation of cellular component organization. Located in basement membrane. Expressed in PVQL; PVQR; hypodermis; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; asthma (multiple); kidney failure (multiple); and lung disease (multiple). Is an ortholog of human PXDN (peroxidasin) and PXDNL (peroxidasin like). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (21) | ||||||||
| Molecular_info | Corresponding_CDS | K09C8.5 | |||||||
| Corresponding_transcript | K09C8.5.1 | ||||||||
| Other_sequence (53) | |||||||||
| Associated_feature | WBsf1006871 | ||||||||
| WBsf237924 | |||||||||
| WBsf237925 | |||||||||
| Experimental_info | RNAi_result (21) | ||||||||
| Expr_pattern | Expr3586 | ||||||||
| Expr9134 | |||||||||
| Expr9135 | |||||||||
| Expr1015080 | |||||||||
| Expr1032100 | |||||||||
| Expr1154107 | |||||||||
| Expr2015201 | |||||||||
| Expr2033435 | |||||||||
| Drives_construct | WBCnstr00013738 | ||||||||
| WBCnstr00013739 | |||||||||
| WBCnstr00020278 | |||||||||
| WBCnstr00035606 | |||||||||
| Construct_product | WBCnstr00011510 | ||||||||
| WBCnstr00013739 | |||||||||
| WBCnstr00035606 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (154) | |||||||||
| Interaction | WBInteraction000537479 | ||||||||
| WBInteraction000537481 | |||||||||
| WBInteraction000573516 | |||||||||
| Map_info | Map | X | Position | 2.78523 | Error | 0.005352 | |||
| Positive | Positive_clone | K09C8 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference (17) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
