| WBGene00004257 | Evidence | Person_evidence | WBPerson345 |
|---|
| SMap | S_parent | Sequence | CHROMOSOME_X |
| Identity | Version | 1 |
| | Name | CGC_name | pxn-2 | Person_evidence | WBPerson345 |
| | | Sequence_name | K09C8.5 |
| | | Molecular_name | K09C8.5 |
| | | | K09C8.5.1 |
| | | | CE18882 |
| | | Other_name | CELE_K09C8.5 | Accession_evidence | NDB | BX284606 |
| | | Public_name | pxn-2 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pxn |
| | Allele (91) |
| | Strain | WBStrain00050779 |
| | | WBStrain00050789 |
| | RNASeq_FPKM (74) |
| | GO_annotation (24) |
| | Ortholog (47) |
| | Paralog | WBGene00004256 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00015841 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00009897 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00011530 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019613 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00022743 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00016700 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019970 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00008627 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00017968 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | pxn-2 encodes a member of the peroxidasin family of extracellular peroxidases containing several LLRs, two of four Ig domains and a heme peroxidase catalytic domain, PXN-2 is closely related to human PXDN and PXDNL (OMIM: 605158); PXN-2 function becomes critical soon after the twofold stage of epidermal elongation in embryos; pxn-2 mutants display defects in late stages of epidermal elongation, in muscle and epidermal muscle attachments, in vulval muscle attachment and in morphology of adult pharynx; PXN-2 supports a role in basement membrane function and in neuronal development, PXN-2 acts in selective axon guidance decisions but not essential for axon growth; PXN-2 inhibits adult axon regrowth after injury; PXN-1 acts antagonistically to PXN-2; PXN-2 expressed in differentiated epidermal cell throughout embryonic, larval and adult development, in vulval muscles and a few neurons, in longitudinal striations adjacent to the body wall muscle quadrant close to endogenous basement membrane components. | Curator_confirmed | WBPerson12884 |
| | | | | Date_last_updated | 22 Jun 2011 00:00:00 |
| | | Automated_description | Predicted to enable peroxidase activity. Involved in several processes, including embryonic body morphogenesis; muscle attachment; and regulation of cellular component organization. Located in basement membrane. Expressed in PVQL; PVQR; hypodermis; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; asthma (multiple); kidney failure (multiple); and lung disease (multiple). Is an ortholog of human PXDN (peroxidasin) and PXDNL (peroxidasin like). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (21) |
| Molecular_info | Corresponding_CDS | K09C8.5 |
| | Corresponding_transcript | K09C8.5.1 |
| | Other_sequence (53) |
| | Associated_feature | WBsf1006871 |
| | | WBsf237924 |
| | | WBsf237925 |
| Experimental_info | RNAi_result (21) |
| | Expr_pattern | Expr3586 |
| | | Expr9134 |
| | | Expr9135 |
| | | Expr1015080 |
| | | Expr1032100 |
| | | Expr1154107 |
| | | Expr2015201 |
| | | Expr2033435 |
| | Drives_construct | WBCnstr00013738 |
| | | WBCnstr00013739 |
| | | WBCnstr00020278 |
| | | WBCnstr00035606 |
| | Construct_product | WBCnstr00011510 |
| | | WBCnstr00013739 |
| | | WBCnstr00035606 |
| | Microarray_results (18) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00045050:csr-1(hypomorph)_upregulated |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00045934:wrn-1(gk99)_upregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day5 |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:ham-3(RNAi)_upregulated |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049954:BPS_upregulated |
| | | WBPaper00050080:rbr-2(tm3141)_downregulated |
| | | WBPaper00050332:skn-1(RNAi)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053402:cco-1(RNAi)_upregulated |
| | | WBPaper00053664:ins-11(tm1053)_upregulated |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056034:pals-25(jy9)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056167:ifo-1(kc2)_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L3 |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056617:adr-1_upregulated_L4_transcript |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00057068:numr-1(RNAi)_downregulated_Cadmium |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059605:mut-16(pk710)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:Body_wall_muscle |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:T24C12.3-C01G10.9 |
| | | WBPaper00061753:csr-1(tor159)_downregulated_25C |
| | | WBPaper00062184:PA14_downregulated |
| | | WBPaper00062193:daf-16(RNAi)_upregulated |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_N2 |
| | | WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13) |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141) |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065074:glna(-)_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_25C |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:1_2 |
| | | WBPaper00065841:7_4 |
| | | WBPaper00065841:62_0 |
| | | WBPaper00065841:74_0 |
| | | WBPaper00065841:94_0 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | WBPaper00025032:cluster_24 |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00038172:crh-1null_up_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040876:mir-35_upregulated |
| | | WBPaper00040963:TA100_up |
| | | WBPaper00040963:TA200_up |
| | | WBPaper00040963:TA300_up |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00047070:xpa-1_UV_upregulated |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc6390]:Cluster_C |
| | Interaction | WBInteraction000537479 |
| | | WBInteraction000537481 |
| | | WBInteraction000573516 |
| Map_info | Map | X | Position | 2.78523 | Error | 0.005352 |
| | Positive | Positive_clone | K09C8 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (17) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
