WormBase Tree Display for Gene: WBGene00004244

WBGene00004244 SMap: S_parent: Sequence: C30G12
  Identity: Version: 2
    Name: CGC_name: puf-8 Person_evidence: WBPerson320
      Sequence_name: C30G12.7
      Molecular_name: C30G12.7
        C30G12.7.1
        CE37486
      Other_name: teg-2 Person_evidence: WBPerson555
        CELE_C30G12.7 Accession_evidence: NDB BX284602
      Public_name: puf-8
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 14 Aug 2012 14:38:21 WBPerson2970 Event: Acquires_merge: WBGene00006564
              Name_change: Other_name: teg-2
      Acquires_merge: WBGene00006564
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: puf
    Allele (42)
    Strain: WBStrain00022254
      WBStrain00022619
      WBStrain00022166
      WBStrain00022639
    RNASeq_FPKM (74)
    GO_annotation: 00054170
      00054171
      00054172
      00054173
      00054174
      00054175
      00054176
      00054177
      00054178
      00054179
      00054180
      00054181
      00112535
    Contained_in_operon: CEOP2292
    Ortholog (33)
    Paralog: WBGene00001401 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001402 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004239 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004241 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004242 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004243 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004245 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00022257 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: puf-8 encodes a member of the PUF family of RNA binding proteins. Paper_evidence: WBPaper00042132
          Curator_confirmed: WBPerson1843
          Date_last_updated: 01 Apr 2014 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in male meiotic nuclear division; negative regulation of MAPK cascade; and spermatogenesis. Located in P granule and nuclear periphery. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; germ line; sperm; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Is an ortholog of human PUM1 (pumilio RNA binding family member 1) and PUM2 (pumilio RNA binding family member 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
    Potential_model: DOID:0111743 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:14957)
  Models_disease_in_annotation: WBDOannot00001263
  Molecular_info: Corresponding_CDS: C30G12.7
    Corresponding_CDS_history: C30G12.7:wp130
    Corresponding_transcript: C30G12.7.1
    Other_sequence: CR01371
      CRC02691_1
      CJC01330_1
    Associated_feature: WBsf019217
      WBsf019218
      WBsf223321
    Gene_product_binds: WBsf899537
      WBsf899538
      WBsf899539
      WBsf899540
  Experimental_info: RNAi_result (24)
    Expr_pattern (11)
    Drives_construct (12)
    Construct_product: WBCnstr00005726
      WBCnstr00005727
      WBCnstr00017042
      WBCnstr00017521
      WBCnstr00017549
      WBCnstr00017550
      WBCnstr00017551
      WBCnstr00017552
      WBCnstr00035610
    Regulate_expr_cluster: WBPaper00045618:puf-8_downregulated
      WBPaper00045618:puf-8_upregulated
    Microarray_results (19)
    Expression_cluster (127)
    Interaction: WBInteraction000004892
      WBInteraction000005368
      WBInteraction000008873
      WBInteraction000008874
      WBInteraction000031599
      WBInteraction000050643
      WBInteraction000324013
      WBInteraction000354164
      WBInteraction000413349
      WBInteraction000419658
      WBInteraction000434481
      WBInteraction000436620
      WBInteraction000456055
      WBInteraction000500912
      WBInteraction000502158
      WBInteraction000505041
      WBInteraction000505042
      WBInteraction000505043
      WBInteraction000505044
      WBInteraction000505045
      WBInteraction000505046
      WBInteraction000505047
      WBInteraction000505048
      WBInteraction000517228
      WBInteraction000517229
      WBInteraction000519508
      WBInteraction000519509
      WBInteraction000519568
      WBInteraction000525426
      WBInteraction000541676
      WBInteraction000551310
      WBInteraction000551311
      WBInteraction000551312
      WBInteraction000551313
      WBInteraction000551314
      WBInteraction000551315
      WBInteraction000551316
      WBInteraction000558872
      WBInteraction000565692
      WBInteraction000566104
      WBInteraction000569090
      WBInteraction000569091
      WBInteraction000575711
    WBProcess: WBbiopr:00000069
  Map_info: Map: II Position: 0.500136 Error: 0.000128
    Positive: Positive_clone: C30G12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4171
        4615
        5564
        3796
        3826
    Pseudo_map_position
  Reference (78)
  Remark: sequence connection from [Bernstein M, Wickens MP]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene