WormBase Tree Display for Gene: WBGene00004210

WBGene00004210 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y110A2AL
  Identity: Version: 1
    Name: CGC_name: ptc-3 Person_evidence: WBPerson349
      Sequence_name: Y110A2AL.8
      Molecular_name: Y110A2AL.8a
        Y110A2AL.8a.1
        CE37163
        Y110A2AL.8b
        CE37164
        Y110A2AL.8c
        CE42182
        Y110A2AL.8b.1
        Y110A2AL.8c.1
      Other_name: Y110A2AL.j Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y110A2AL.8 Accession_evidence: NDB BX284602
      Public_name: ptc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ptc
    Allele (195)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Ortholog (41)
    Paralog (31)
    Structured_description: Concise_description: ptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability. Paper_evidence: WBPaper00004265
            WBPaper00026841
            WBPaper00027263
          Curator_confirmed: WBPerson567
          Date_last_updated: 08 Nov 2006 00:00:00
      Automated_description: Predicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (18)
  Molecular_info: Corresponding_CDS: Y110A2AL.8a
      Y110A2AL.8b
      Y110A2AL.8c
    Corresponding_CDS_history: Y110A2AL.8a:wp127
      Y110A2AL.8b:wp127
    Corresponding_transcript: Y110A2AL.8a.1
      Y110A2AL.8b.1
      Y110A2AL.8c.1
    Other_sequence (34)
    Associated_feature (13)
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr9231
      Expr9232
      Expr1017786
      Expr1032067
      Expr1158842
      Expr2015145
      Expr2033383
    Drives_construct: WBCnstr00008494
      WBCnstr00008496
      WBCnstr00035634
    Construct_product: WBCnstr00008494
      WBCnstr00008495
      WBCnstr00008496
      WBCnstr00008497
      WBCnstr00008498
      WBCnstr00008502
      WBCnstr00035634
    Antibody: WBAntibody00002998
    Microarray_results (31)
    Expression_cluster: WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_CoreEnriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00041954:ethanol_upregulated
      WBPaper00043945:MeHg_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045417:128Q-huntingtin_downreglated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Oogenic
      WBPaper00046121:ecdoderm_unique
      WBPaper00046499:AMPK_regulated
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048690:gonad-male-biased
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049594:osm-9(ok1677)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00053020:OrsayVirus-infection_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053615:SMO-1_target
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00055013:hmg-3(bar24)_downregulated
      WBPaper00055013:spt-16(RNAi)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055827:pfd-6(gk493446)_downregulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056169:rrf-3(pk1426)_downregulated_L4
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056290:mdt-15(mg584)_upregulated
      WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
      WBPaper00057068:numr-1(RNAi)_downregulated
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00058958:100mGy-irradiation-72h_upregulated
      WBPaper00059231:alh-6(lax105)_L4_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060445:nfki-1(cer1)_downregulated_L4
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:B_F_K_Kp_U_Y
      WBPaper00061340:Hypodermis
      WBPaper00061340:ILso
      WBPaper00061340:Tail_hypodermis
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4748)_upregulated
      WBPaper00061527:lon-8-C18D11.1_11630
      WBPaper00061692:acivicin_upregulated
      WBPaper00062118:neural-HSF-1_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062456:doxycycline_upregulated_CB4856_protein
      WBPaper00062456:doxycycline_upregulated_N2_protein
      WBPaper00062498:PPM-1.D_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mes-3(bn199)_upregulated_EGCs
      WBPaper00064315:mes-4(bn73)_upregulated_EGCs
      WBPaper00064532:pals-25(icb98)_downregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065258:anchor-cell_enriched
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065841:0_0
      WBPaper00065841:30_2
      WBPaper00065841:33_0
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4386_cluster_4_6
      cgc4386_cluster_5_6
      cgc4489_group_8
      cgc4489_group_20
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:Resveratrol_regulated_N2
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:FedUp
      WBPaper00032948:MoltOssilate
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035084:L2_enriched_AIN-2_IP
      WBPaper00035084:L3_enriched_AIN-2_IP
      WBPaper00035084:L4_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036130:mir-243_up_regulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_down_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040185:nhr-23(RNAi)_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040876:mir-35_downregulated
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046083:oga-1(ok1207)_OP50_downregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00047070:N2_UV_downregulated
      WBPaper00047070:xpa-1_UV_downregulated
      WBPaper00048929:ethosuximide_upregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc6390]:Cluster_B
      [cgc6390]:male_soma-enriched
    Interaction: WBInteraction000009897
      WBInteraction000028310
      WBInteraction000028552
      WBInteraction000028554
      WBInteraction000028556
      WBInteraction000028680
      WBInteraction000028682
      WBInteraction000028740
      WBInteraction000028886
      WBInteraction000029173
      WBInteraction000032567
      WBInteraction000032777
      WBInteraction000032783
      WBInteraction000032785
      WBInteraction000032965
      WBInteraction000033294
      WBInteraction000033434
      WBInteraction000034524
      WBInteraction000034550
      WBInteraction000034633
      WBInteraction000035131
      WBInteraction000035271
      WBInteraction000036312
      WBInteraction000038139
      WBInteraction000038356
      WBInteraction000038527
      WBInteraction000038658
      WBInteraction000039008
      WBInteraction000039608
      WBInteraction000040024
      WBInteraction000040175
      WBInteraction000040610
      WBInteraction000040633
      WBInteraction000040736
      WBInteraction000040891
      WBInteraction000040939
      WBInteraction000041239
      WBInteraction000041340
      WBInteraction000041766
      WBInteraction000043132
      WBInteraction000043471
      WBInteraction000043539
      WBInteraction000043735
      WBInteraction000044290
      WBInteraction000044416
      WBInteraction000044434
      WBInteraction000044462
      WBInteraction000044817
      WBInteraction000044833
      WBInteraction000044838
      WBInteraction000046122
      WBInteraction000046515
      WBInteraction000047175
      WBInteraction000047352
      WBInteraction000047731
      WBInteraction000048522
      WBInteraction000049040
      WBInteraction000049126
      WBInteraction000049411
      WBInteraction000049849
      WBInteraction000114599
      WBInteraction000114601
      WBInteraction000114603
      WBInteraction000114605
      WBInteraction000114615
      WBInteraction000114616
      WBInteraction000114617
      WBInteraction000114618
      WBInteraction000114626
      WBInteraction000161029
      WBInteraction000161045
      WBInteraction000161046
      WBInteraction000162357
      WBInteraction000172934
      WBInteraction000502478
      WBInteraction000551578
      WBInteraction000554221
      WBInteraction000580274
    WBProcess: WBbiopr:00000123
  Map_info: Map: II Position: -9.82406 Error: 0.084736
    Positive: Positive_clone: Y110A2AL Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene