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WormBase Tree Display for Gene: WBGene00004210

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Name Class

WBGene00004210EvidenceCGC_data_submission
SMapS_parentSequenceY110A2AL
IdentityVersion1
NameCGC_nameptc-3Person_evidenceWBPerson349
Sequence_nameY110A2AL.8
Molecular_nameY110A2AL.8a
Y110A2AL.8a.1
CE37163
Y110A2AL.8b
CE37164
Y110A2AL.8c
CE42182
Y110A2AL.8b.1
Y110A2AL.8c.1
Other_nameY110A2AL.jCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_Y110A2AL.8Accession_evidenceNDBBX284602
Public_nameptc-3
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classptc
Allele (195)
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (41)
Paralog (31)
Structured_descriptionConcise_descriptionptc-3 encodes an ortholog of Drosophila PATCHED (PTC) and human PTCH(OMIM:601309, mutated in basal cell nevus syndrome), which defines oneof seven paralogous families of sterol sensing domain (SSD) proteins;PTC-3 is strongly required for normal molting from L1 to L3 larvalstages; PTC-3 is also required for normal growth to full size and forviability.Paper_evidenceWBPaper00004265
WBPaper00026841
WBPaper00027263
Curator_confirmedWBPerson567
Date_last_updated08 Nov 2006 00:00:00
Automated_descriptionPredicted to enable hedgehog family protein binding activity; hedgehog receptor activity; and smoothened binding activity. Involved in molting cycle. Located in apical plasma membrane and cytoplasmic vesicle. Expressed in several structures, including CEP; cloaca; egg-laying apparatus; excretory duct; and preanal ganglion. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); colorectal adenoma; and holoprosencephaly 7. Is an ortholog of human PTCH1 (patched 1) and PTCH2 (patched 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (18)
Molecular_infoCorresponding_CDSY110A2AL.8a
Y110A2AL.8b
Y110A2AL.8c
Corresponding_CDS_historyY110A2AL.8a:wp127
Y110A2AL.8b:wp127
Corresponding_transcriptY110A2AL.8a.1
Y110A2AL.8b.1
Y110A2AL.8c.1
Other_sequence (34)
Associated_feature (13)
Experimental_infoRNAi_result (14)
Expr_patternExpr9231
Expr9232
Expr1017786
Expr1032067
Expr1158842
Expr2015145
Expr2033383
Drives_constructWBCnstr00008494
WBCnstr00008496
WBCnstr00035634
Construct_productWBCnstr00008494
WBCnstr00008495
WBCnstr00008496
WBCnstr00008497
WBCnstr00008498
WBCnstr00008502
WBCnstr00035634
AntibodyWBAntibody00002998
Microarray_results (31)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:germline-precursors_embryo_enriched
WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_CoreEnriched
WBPaper00037950:hypodermis_embryo_enriched
WBPaper00037950:hypodermis_embryo_SelectivelyEnriched
WBPaper00037950:hypodermis_larva_enriched
WBPaper00037950:hypodermis_larva_SelectivelyEnriched
WBPaper00038168:lin-15B(n744)_downregulated
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040209:B.thuringiensis_downregulated_MY18
WBPaper00041954:ethanol_upregulated
WBPaper00043945:MeHg_upregulated
WBPaper00044260:1-methylnicotinamide_upregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045417:128Q-huntingtin_downreglated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Oogenic
WBPaper00046121:ecdoderm_unique
WBPaper00046499:AMPK_regulated
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048690:gonad-male-biased
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049018:swsn-2.2(RNAi)_downregulated
WBPaper00049594:osm-9(ok1677)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050468:hlh-30-dependent_Cry5B_regulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050801:DAF-12_dauer_regulome
WBPaper00050801:DAF-16_dauer_regulome
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050990:hypodermis_enriched
WBPaper00050990:hypodermis_expressed
WBPaper00051021:4-bromodiphenyl-ether_upregulated
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00053020:OrsayVirus-infection_downregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053615:SMO-1_target
WBPaper00054493:hpl-2(tm1489)_upregulated
WBPaper00055013:hmg-3(bar24)_downregulated
WBPaper00055013:spt-16(RNAi)_downregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055827:pfd-6(gk493446)_downregulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056290:mdt-15(mg584)_upregulated
WBPaper00056293:rpl-5(0)-rpl-33(0)_downregulated
WBPaper00056330:glycine_downregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057068:ints-4(RNAi)_downregulated_Cadmium
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058725:sftb-1(cer39)_downregulated
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059231:alh-6(lax105)_L4_upregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
WBPaper00059604:fluvastatin_downregulated_N2
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060445:nfki-1(cer1)_downregulated_L4
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:B_F_K_Kp_U_Y
WBPaper00061340:Hypodermis
WBPaper00061340:ILso
WBPaper00061340:Tail_hypodermis
WBPaper00061341:28C_24h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4748)_upregulated
WBPaper00061527:lon-8-C18D11.1_11630
WBPaper00061692:acivicin_upregulated
WBPaper00062118:neural-HSF-1_downregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062456:doxycycline_upregulated_N2_protein
WBPaper00062498:PPM-1.D_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064315:mes-3(bn199)_upregulated_EGCs
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064539:nhr-114(gk849)_downregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064727:daf-2(e1370)_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065258:anchor-cell_enriched
WBPaper00065373:Cisplatin_downregulated_WT
WBPaper00065841:0_0
WBPaper00065841:30_2
WBPaper00065841:33_0
WBPaper00065945:epidermis-rpoa-2(-)_downregulated_protein
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066110:tetraploid_vs_diploid_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
cgc4386_cluster_4_6
cgc4386_cluster_5_6
cgc4489_group_8
cgc4489_group_20
WBPaper00024393:strongly_regulated_dauer_genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:Resveratrol_regulated_N2
WBPaper00026980:intestine_enriched
WBPaper00028789:PA14_vs_OP50_upregulated_4hr
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031832:slr-2_regulated
WBPaper00032948:FedUp
WBPaper00032948:MoltOssilate
WBPaper00035084:embryo_enriched_AIN-2_IP
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035084:L2_enriched_AIN-2_IP
WBPaper00035084:L3_enriched_AIN-2_IP
WBPaper00035084:L4_enriched_AIN-2_IP
WBPaper00035227:heat_shock_regulated
WBPaper00035560:ahr-1_downregulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00035905:FBF-1_Associated
WBPaper00036130:mir-243_up_regulated
WBPaper00038172:crh-1null_down_regulated
WBPaper00038172:tax-6null_down_regulated
WBPaper00038304:octr-1_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040185:nhr-23(RNAi)_downregulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040876:mir-35_downregulated
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00046083:oga-1(ok1207)_OP50_downregulated
WBPaper00046083:pmk-1(km25)_OP50_downregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00047070:N2_UV_downregulated
WBPaper00047070:xpa-1_UV_downregulated
WBPaper00048929:ethosuximide_upregulated
WBPaper00056330:mrps-5(RNAi)_upregulated
[cgc6390]:Cluster_B
[cgc6390]:male_soma-enriched
Interaction (78)
WBProcessWBbiopr:00000123
Map_infoMapIIPosition-9.82406Error0.084736
PositivePositive_cloneY110A2ALInferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
Reference (21)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene