WormBase Tree Display for Gene: WBGene00004189

WBGene00004189 SMap: S_parent: Sequence: T20H4
  Identity: Version: 2
    Name: CGC_name: pars-1 Person_evidence: WBPerson36
            WBPerson10953
      Sequence_name: T20H4.3
      Molecular_name: T20H4.3a
        T20H4.3a.1
        CE00748
        T20H4.3b
        CE37410
        T20H4.3b.1
      Other_name: prs-1
        CELE_T20H4.3 Accession_evidence: NDB BX284603
      Public_name: pars-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Jan 2010 14:16:16 WBPerson2970 Name_change: CGC_name: pars-1
                Other_name: prs-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pars
    Allele (15)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (36)
    Paralog: WBGene00000659 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00001337 Caenorhabditis elegans From_analysis: Panther
      WBGene00004190 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006617 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044344 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: prs-1 encodes a predicted cytoplasmic prolyl-tRNA synthetase (ProRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of proline to its cognate tRNA and is thus required for protein biosynthesis; PRS-1 is required for embryonic, germline, and postembryonic development. Paper_evidence: WBPaper00004403
            WBPaper00004651
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Is an ortholog of human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070398 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3418)
  Molecular_info: Corresponding_CDS: T20H4.3a
      T20H4.3b
    Corresponding_CDS_history: T20H4.3:wp130
    Corresponding_transcript: T20H4.3a.1
      T20H4.3b.1
    Other_sequence (103)
    Associated_feature (12)
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr1028773
      Expr1032049
      Expr1157227
      Expr2014738
      Expr2032972
    Drives_construct: WBCnstr00037929
    Construct_product: WBCnstr00037929
    Microarray_results (24)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00032031:DConiospora_upregulated_cDNA_12h
      WBPaper00032031:DConiospora_upregulated_cDNA_24h
      WBPaper00032528:L3_enriched
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00038289:oocyte_protein
      WBPaper00041072:UTX-1_interacting_protein
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-4(RNAi)_downregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:DAF-16_downregulated
      WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-2(rax5)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_embryo_SMARTseq
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00053810:nuo-6(qm200)_downregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055648:germline_expressed
      WBPaper00055969:electromagnetic-field_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00057041:unc-70(cas983)_upregulated
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00057288:iff-1(RNAi)_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:CFP-1_interacting_protein
      WBPaper00058691:set-2(bn129)_upregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059605:MUT-16_interacting
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061341:28C_24h_downregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061478:SUMO-conjugated_protein
      WBPaper00061527:Y45F10D.7-C14C10.4
      WBPaper00061651:SIA_enriched
      WBPaper00061651:VB01_enriched
      WBPaper00062056:lin-35(n745)_upregulated
      WBPaper00062143:PQN-59_interacting
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
      WBPaper00064163:ZNFX-1_interacting_embryo
      WBPaper00064716:paraquat_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065841:13_0
      WBPaper00065993:glp-1(e2141)_downregulated
      cgc4489_group_3
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031003:hlh_1_enriched
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:FedUp
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00036286:Pattern_H
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00044091:Bpseudomallei_induced_8h
      WBPaper00044091:Bpseudomallei_induced_12h
      WBPaper00047070:N2_starvation_downregulated
      WBPaper00048637:lin-35(n745)_starvation_upregulated
      WBPaper00048989:N2_rapamycin_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(122_min)
      [cgc5767]:expression_class_E_pi(143_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_MD
      [cgc5767]:expression_class_MDE
      [cgc5767]:expression_class_MD_pd(23_min)
      [cgc5767]:expression_class_ME
      [cgc6390]:intrinsic
    Interaction (277)
  Map_info: Map: III Position: -0.766312 Error: 0.000666
    Positive: Positive_clone: T20H4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00035228
    WBPaper00038491
    WBPaper00055090
    WBPaper00057218
  Remark: Connection made from predicted gene which has synthetase Pfam domain similarity. [sdm 12/01]
    dl1 : porbably cytoplasmic
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene