WormBase Tree Display for Gene: WBGene00004140
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| WBGene00004140 | SMap | S_parent | Sequence | R09E10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | ebax-1 | Person_evidence | WBPerson293 | |||||
| Sequence_name | R09E10.7 | ||||||||
| Molecular_name | R09E10.7 | ||||||||
| R09E10.7.1 | |||||||||
| CE37845 | |||||||||
| Other_name | pqn-55 | Person_evidence | WBPerson625 | ||||||
| CELE_R09E10.7 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | ebax-1 | ||||||||
| DB_info | Database | AceView | gene | 4L57 | |||||
| WormQTL | gene | WBGene00004140 | |||||||
| WormFlux | gene | WBGene00004140 | |||||||
| NDB | locus_tag | CELE_R09E10.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004140|UniProtKB=Q21875 | |||||||
| family | PTHR22619 | ||||||||
| NCBI | gene | 177915 | |||||||
| RefSeq | protein | NM_069487.7 | |||||||
| TREEFAM | TREEFAM_ID | TF324881 | |||||||
| TrEMBL | UniProtAcc | Q21875 | |||||||
| UniProt_GCRP | UniProtAcc | Q21875 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 10 Jul 2013 13:59:51 | WBPerson2970 | Name_change | CGC_name | ebax-1 | ||||
| Other_name | pqn-55 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ebax | ||||||||
| Allele (84) | |||||||||
| Strain | WBStrain00050654 | ||||||||
| WBStrain00050655 | |||||||||
| WBStrain00052085 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (45) | |||||||||
| Structured_description | Concise_description | ebax-1 encodes a conserved BC-box-containing protein; EBAX-1 functions as part of a protein quality control mechanism that ensures proper axon guidance; specifically, EBAX-1 functions as a substrate-recognition subunit for misfolded SAX-3 in an Elongin BC-containing Cullin-RING ubiquitin ligase (CRL) complex that promotes degradation of misfolded SAX-3/Robo receptor; EBAX-1 function is particularly critical for thermotolerance of axon guidance; in regulating protein quality control, EBAX-1 functions together and physically interacts with DAF-21, a C. elegans Hsp90 homolog; EBAX-1 is expressed during embryonic and larval stages, and acts cell autonomously in neurons, particularly developing neurons, where it localizes to the cytosol. | Paper_evidence | WBPaper00044158 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Sep 2014 00:00:00 | ||||||||
| Automated_description | Enables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in positive regulation of miRNA catabolic process; regulation of locomotion; and regulation of reproductive process. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Expressed in excretory cell; nervous system; and vulval muscle. Is an ortholog of human ZSWIM8 (zinc finger SWIM-type containing 8). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | R09E10.7 | |||||||
| Corresponding_CDS_history | R09E10.7:wp136 | ||||||||
| Corresponding_transcript | R09E10.7.1 | ||||||||
| Other_sequence | Tcir_isotig20209 | ||||||||
| CRC00576_1 | |||||||||
| GE625664.1 | |||||||||
| CR03532 | |||||||||
| JI163992.1 | |||||||||
| Dviv_isotig23842 | |||||||||
| Associated_feature | WBsf660575 | ||||||||
| WBsf660576 | |||||||||
| WBsf660577 | |||||||||
| WBsf228977 | |||||||||
| WBsf228978 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00072280 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00051626 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00017651 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00034784 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00081120 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00051625 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr11256 | ||||||||
| Expr12595 | |||||||||
| Expr1028257 | |||||||||
| Expr1032014 | |||||||||
| Expr1155298 | |||||||||
| Expr2011161 | |||||||||
| Expr2029397 | |||||||||
| Drives_construct | WBCnstr00019380 | ||||||||
| WBCnstr00022366 | |||||||||
| WBCnstr00037933 | |||||||||
| Construct_product | WBCnstr00019380 | ||||||||
| WBCnstr00037933 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (134) | |||||||||
| Interaction | WBInteraction000456278 | ||||||||
| WBInteraction000523851 | |||||||||
| WBInteraction000523852 | |||||||||
| WBInteraction000523853 | |||||||||
| WBInteraction000549241 | |||||||||
| WBInteraction000575353 | |||||||||
| Anatomy_function | WBbtf0601 | ||||||||
| WBbtf0602 | |||||||||
| Map_info | Map | IV | Position | 4.57168 | Error | 0.00135 | |||
| Positive | Positive_clone | R09E10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4603 | |||||||
| 4622 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (12) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
