WormBase Tree Display for Gene: WBGene00004134
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WBGene00004134 | SMap | S_parent | Sequence | CHROMOSOME_II | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | myrf-1 | Person_evidence | WBPerson7150 | |||
Sequence_name | F59B10.1 | ||||||
Molecular_name | F59B10.1 | ||||||
F59B10.1.1 | |||||||
CE36940 | |||||||
Other_name | pqn-47 | Person_evidence | WBPerson625 | ||||
CELE_F59B10.1 | Accession_evidence | NDB | BX284602 | ||||
Public_name | myrf-1 | ||||||
DB_info | Database (12) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | myrf | ||||||
Allele (84) | |||||||
Possibly_affected_by | WBVar02157207 | ||||||
Strain | WBStrain00037532 | ||||||
WBStrain00037768 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog (43) | |||||||
Paralog | WBGene00008999 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | myrf-1 encodes a protein with a glutamine/asparagine-rich domain, orthologous to human MYRF (myelin regulatory factor); in C. elegans, MYRF-1 activity is required for regulation of the molting cycle, specifically the completion of larval molts and cessation of molting in reproductively mature adult animals; a MYRF-1::GFP fusion protein is expressed in a wide variety of cells and tissues, including neurons, secretory cells, and hypodermal seam cells, but is not seen in the hyp7 syncytial hypodermis; expression begins in the comma stage of embryogenesis and persists through adulthood; full length C. elegans MYRF-1::GFP localizes to the cytoplasm where it partially overlaps with the endoplasmic reticulum; MYRF-1 contains a well-conserved paralog in the C. elegans genome, MYRF-2, encoded by F21A10.2. | Paper_evidence | WBPaper00004651 | |||
WBPaper00005487 | |||||||
WBPaper00005654 | |||||||
WBPaper00012811 | |||||||
WBPaper00040293 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 19 Dec 2014 00:00:00 | ||||||
Automated_description | Predicted to enable DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in ecdysis, collagen and cuticulin-based cuticle and nematode larval development. Located in basal part of cell and endoplasmic reticulum. Expressed in several structures, including ciliated neurons; excretory duct; gonad; pharyngeal cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; and eye disease (multiple). Is an ortholog of human MYRFL (myelin regulatory factor like). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0080634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||
DOID:3827 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||
DOID:9834 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||
DOID:1405 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||
DOID:3526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1181) | ||||
Molecular_info | Corresponding_CDS | F59B10.1 | |||||
Corresponding_CDS_history | F59B10.1:wp127 | ||||||
Corresponding_transcript | F59B10.1.1 | ||||||
Other_sequence | CR10282 | ||||||
CR10281 | |||||||
CRC03559_1 | |||||||
ACC07624_1 | |||||||
SRC00534_1 | |||||||
EY470006.1 | |||||||
Tcol_isotig21011 | |||||||
SR01712 | |||||||
Name_isotig07910 | |||||||
JI164614.1 | |||||||
Associated_feature (15) | |||||||
Transcription_factor | WBTranscriptionFactor000563 | ||||||
Experimental_info | RNAi_result (46) | ||||||
Expr_pattern (14) | |||||||
Drives_construct | WBCnstr00004111 | ||||||
WBCnstr00009459 | |||||||
WBCnstr00009460 | |||||||
WBCnstr00014243 | |||||||
WBCnstr00014244 | |||||||
WBCnstr00019909 | |||||||
WBCnstr00037934 | |||||||
Construct_product | WBCnstr00009460 | ||||||
WBCnstr00014243 | |||||||
WBCnstr00014244 | |||||||
WBCnstr00037934 | |||||||
Regulate_expr_cluster | WBPaper00061377:MYRF-1_interacting | ||||||
Microarray_results (16) | |||||||
Expression_cluster (185) | |||||||
Interaction (679) | |||||||
Anatomy_function | WBbtf1093 | ||||||
WBbtf1094 | |||||||
WBbtf1095 | |||||||
Map_info | Map | II | Position | 2.9838 | Error | 0.041984 | |
Positive | Positive_clone | F59B10 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (14) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |