| WBGene00004077 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | CHROMOSOME_I |
| Identity | Version | 1 |
| | Name | CGC_name | pop-1 | Person_evidence | WBPerson498 |
| | | Sequence_name | W10C8.2 |
| | | Molecular_name | W10C8.2 |
| | | | W10C8.2.1 |
| | | | CE46967 |
| | | Other_name | sys-2 |
| | | | CELE_W10C8.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | pop-1 |
| | DB_info | Database (12) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | pop |
| | Allele (168) |
| | Legacy_information | [Lin R] Pop (posterior pharynx defective) phenotype: maternal lethal, causing MS blastomere to adopt the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. zu189 isolated in mutator background, probable Tc1 insertion. |
| | | [C.elegansII] zu189mut : maternal effect embryonic lethal,no MS-derived pharyngeal cells; MS blastomere adopts the fate of sister blastomere E; resulting embryos have twice the wildtype amount of gut. NA1. Cloned: encodes predicted 487 aa protein with HMG box; antibody stains nuclei of oocytes, early blastomeres. [Lin et al. 1995; JJ] |
| | Strain (11) |
| | RNASeq_FPKM (74) |
| | GO_annotation (113) |
| | Ortholog (59) |
| | Structured_description | Concise_description | pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva. | Paper_evidence | WBPaper00002330 |
| | | | | | WBPaper00004103 |
| | | | | | WBPaper00005116 |
| | | | | | WBPaper00024693 |
| | | | | | WBPaper00026603 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 04 Aug 2005 00:00:00 |
| | | Automated_description | Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including mesodermal cell fate commitment; regulation of cell division; and regulation of gene expression. Located in cytoplasm and nucleus. Expressed in several structures, including ABplpapaaa; ABprpapaaa; oocyte; somatic nervous system; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); endocrine gland cancer (multiple); and prostate disease (multiple). Is an ortholog of human TCF7L2 (transcription factor 7 like 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 28 Jun 2022 00:00:00 |
| | Potential_model | DOID:9351 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) |
| | | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) |
| | | DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) |
| | | DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) |
| | | DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) |
| | | DOID:8634 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6551) |
| | | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11639,HGNC:11641,HGNC:6551) |
| | | DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) |
| | | DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11641) |
| Models_disease_in_annotation | WBDOannot00001266 |
| Molecular_info | Corresponding_CDS | W10C8.2 |
| | Corresponding_CDS_history | W10C8.2:wp229 |
| | Corresponding_transcript | W10C8.2.1 |
| | Other_sequence (26) |
| | Associated_feature (14) |
| | Gene_product_binds (20) |
| | Transcription_factor | WBTranscriptionFactor000102 |
| Experimental_info | RNAi_result (249) |
| | Expr_pattern (15) |
| | Drives_construct | WBCnstr00001895 |
| | | WBCnstr00012848 |
| | | WBCnstr00035711 |
| | Construct_product (13) |
| | Antibody | WBAntibody00000100 |
| | | WBAntibody00000162 |
| | | WBAntibody00000612 |
| | | WBAntibody00000723 |
| | | WBAntibody00000724 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050412:cco-1(RNAi)_upregulated_N2 |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050743:elli-1(sam-3)_downregulated |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00054410:set-26(tm2467)_downregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AIN_parent |
| | | WBPaper00061340:ALN |
| | | WBPaper00061340:AMso_parent |
| | | WBPaper00061340:I1_parent |
| | | WBPaper00061340:I2_grandparent |
| | | WBPaper00061340:IL1_parent |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:Neuroblast_ADE_ADA |
| | | WBPaper00061340:Neuroblast_PVC_LUA |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:Parent_of_AMsh_URB |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061340:RME_LR_parent |
| | | WBPaper00061340:URA_parent |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00062159:hda-2(ok1479)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065315:mating_upregulated_Day2-7 |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:51_0 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | WBPaper00025032:cluster_54 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00030985:Serratia_marcesens_upregulated |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00042067:Cu2+_upregulated_WT |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | [cgc5767]:cluster_10 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(83_min) |
| | | [cgc5767]:expression_class_ET_max(101_min) |
| | | [cgc5767]:expression_class_ET_max(143_min) |
| | | [cgc5767]:expression_class_E_pi(41_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SET |
| | | [cgc5767]:expression_class_SE_pi(41_min) |
| | | [cgc5767]:expression_class_SE_pi(53_min) |
| | | [cgc6390]:Cluster_E |
| | Interaction (464) |
| | Anatomy_function | WBbtf0106 |
| | WBProcess | WBbiopr:00000073 |
| | | WBbiopr:00000112 |
| | | WBbiopr:00000114 |
| Map_info | Map | I | Position | -5.32204 | Error | 0.039261 |
| | Well_ordered |
| | Positive | Positive_clone | BF8 |
| | | | W10C8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Negative_clone | K11A2 |
| | Mapping_data | 2_point | 7005 |
| | | | 7006 |
| | | Multi_point | 3030 |
| | | | 4915 |
| | | | 5051 |
| | | Pos_neg_data | 8160 |
| | | | 8161 |
| | | | 8162 |
| | | | 8163 |
| | | | 8164 |
| | | | 8165 |
| | | | 10668 |
| | | | 10669 |
| Reference (328) |
| Picture | WBPicture0000013083 |
| | WBPicture0000013084 |
| Remark (4) |
| Method | Gene |
