WormBase Tree Display for Gene: WBGene00004049
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| WBGene00004049 | SMap | S_parent | Sequence | Y71F9AL | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | parp-1 | Person_evidence | WBPerson236 | |||||
| Sequence_name | Y71F9AL.18 | ||||||||
| Molecular_name (13) | |||||||||
| Other_name | pme-1 | ||||||||
| CELE_Y71F9AL.18 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | parp-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 18 Nov 2014 11:51:19 | WBPerson2970 | Name_change | CGC_name | parp-1 | ||||
| Other_name | pme-1 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | parp | ||||||||
| Allele (323) | |||||||||
| Strain | WBStrain00031749 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (24) | |||||||||
| Ortholog (66) | |||||||||
| Paralog | WBGene00004054 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | |||||
| WBGene00043987 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||||
| WBGene00004050 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004053 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | parp-1 (formerly known as pme-1) encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP1 (OMIM:173870); PARP-1 has two N-terminal zinc fingers that probably bind DNA, and a C-terminal catalytic domain; PARP-1 exhibits poly(ADP-ribose) activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PARP-1 is likely to be required in vivo for repairing broken DNA. | Paper_evidence | WBPaper00005600 | |||||
| WBPaper00025222 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Nov 2014 00:00:00 | ||||||||
| Automated_description | Enables NAD+ ADP-ribosyltransferase activity. Involved in determination of adult lifespan. Predicted to be located in nucleolus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; idiopathic pulmonary fibrosis; and perinatal necrotizing enterocolitis. Is an ortholog of human PARP1 (poly(ADP-ribose) polymerase 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9352 | Homo sapiens | Paper_evidence | WBPaper00053647 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 04 Mar 2019 00:00:00 | ||||||||
| Potential_model (14) | |||||||||
| Models_disease_asserted | WBDOannot00000650 | ||||||||
| Molecular_info | Corresponding_CDS | Y71F9AL.18a | |||||||
| Y71F9AL.18b | |||||||||
| Y71F9AL.18c | |||||||||
| Y71F9AL.18d | |||||||||
| Corresponding_transcript | Y71F9AL.18a.1 | ||||||||
| Y71F9AL.18a.2 | |||||||||
| Y71F9AL.18b.1 | |||||||||
| Y71F9AL.18c.1 | |||||||||
| Y71F9AL.18d.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf976649 | ||||||||
| WBsf976650 | |||||||||
| WBsf983015 | |||||||||
| WBsf983016 | |||||||||
| WBsf1009424 | |||||||||
| WBsf219077 | |||||||||
| WBsf219078 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr2249 | ||||||||
| Expr1023238 | |||||||||
| Expr1031949 | |||||||||
| Expr1161576 | |||||||||
| Expr2014736 | |||||||||
| Expr2032970 | |||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (142) | |||||||||
| Interaction (59) | |||||||||
| Map_info | Map | I | Position | -5.30235 | Error | 0.001434 | |||
| Positive | Positive_clone | Y71F9AL | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4775 | |||||||
| 5051 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (24) | |||||||||
| Remark | Gene information and sequence connection from Serge Desnoyers. krb [020430] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
