WormBase Tree Display for Gene: WBGene00003912
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| WBGene00003912 | SMap | S_parent | Sequence | C38D4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pal-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C38D4.6 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | ceh-3 | ||||||||
| nob-2 | |||||||||
| CELE_C38D4.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pal-1 | ||||||||
| DB_info | Database | AceView | gene | 3F896 | |||||
| WormQTL | gene | WBGene00003912 | |||||||
| SignaLink | protein | WBGene00003912 | |||||||
| WormFlux | gene | WBGene00003912 | |||||||
| NDB | locus_tag | CELE_C38D4.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003912|UniProtKB=P34766 | |||||||
| family | PTHR24332 | ||||||||
| NCBI | gene | 175638 | |||||||
| RefSeq | protein | NM_001393326.1 | |||||||
| NM_001267992.4 | |||||||||
| NM_001026038.7 | |||||||||
| SwissProt | UniProtAcc | P34766 | |||||||
| UniProt_GCRP | UniProtAcc | P34766 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pal | ||||||||
| Allele (71) | |||||||||
| Legacy_information | See also e2091 | ||||||||
| [C.elegansII] e2091 : adult males lack V6-derived rays, alae extend into tail region; V6 lineage transformed into V1-V4; cell autonomous action;variable additional defects, some embryonic lethality.OA3: mu13 (similar to e2091), ct224 (pka nob-2, lethal with arrest at hatching, severely deformed posterior, deletion null), ct281. Cloned: 1.25 and 1.45 kb transcripts, encode homeoprotein (pka ceh-3) with similarity to Drosophila caudal, mouse cdx-1. [Waring and Kenyon 1991; Waring et al. 1992; CF; BW] | |||||||||
| Strain (12) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (32) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00003779 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for specification of the C and D posterior blastomere fates and thus, for proper bodywall muscle and hypodermal development during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; in regulating embryonic bodywall muscle specification, PAL-1 binds to an enhancer element in the promoter of hlh-1, the sole C. elegans MRF family member, to positively regulate hlh-1 transcription; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. | Paper_evidence | WBPaper00001409 | |||||
| WBPaper00002573 | |||||||||
| WBPaper00003428 | |||||||||
| WBPaper00004312 | |||||||||
| WBPaper00004499 | |||||||||
| WBPaper00013507 | |||||||||
| WBPaper00032967 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 27 Apr 2009 00:00:00 | ||||||||
| Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate commitment; embryonic pattern specification; and positive regulation of DNA-templated transcription. Located in condensed nuclear chromosome. Expressed in several structures, including ABprpppppaa; enteric muscle; epithelial cell; oocyte; and tail spike. Human ortholog(s) of this gene implicated in Barrett's esophagus. Is an ortholog of human CDX1 (caudal type homeobox 1) and CDX2 (caudal type homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9206 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1806) | ||||
| Molecular_info | Corresponding_CDS | C38D4.6a | |||||||
| C38D4.6b | |||||||||
| C38D4.6c | |||||||||
| Corresponding_CDS_history | C38D4.6:wp52 | ||||||||
| Corresponding_transcript | C38D4.6a.1 | ||||||||
| C38D4.6a.2 | |||||||||
| C38D4.6b.1 | |||||||||
| C38D4.6b.2 | |||||||||
| C38D4.6c.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (30) | |||||||||
| Gene_product_binds | WBsf028060 | ||||||||
| WBsf047529 | |||||||||
| WBsf047531 | |||||||||
| WBsf132694 | |||||||||
| WBsf132695 | |||||||||
| Transcription_factor | WBTranscriptionFactor000142 | ||||||||
| Experimental_info (11) | |||||||||
| Map_info | Map | III | Position | -2.46048 | Error | 0.0149 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | AC10 | |||||||
| C38D4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| W05E6 | |||||||||
| Mapping_data | 2_point | 4229 | |||||||
| 6036 | |||||||||
| Multi_point | 1482 | ||||||||
| 1483 | |||||||||
| 2081 | |||||||||
| 2083 | |||||||||
| 2085 | |||||||||
| 2086 | |||||||||
| 2800 | |||||||||
| 3179 | |||||||||
| Landmark_gene | |||||||||
| Reference (204) | |||||||||
| Remark | testing swap around with kP101. from -2.58 to -2.829 | ||||||||
| Method | Gene |
