WormBase Tree Display for Gene: WBGene00003912
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WBGene00003912 | SMap | S_parent | Sequence | C38D4 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | pal-1 | Person_evidence | WBPerson261 | |||||
Sequence_name | C38D4.6 | ||||||||
Molecular_name (11) | |||||||||
Other_name | ceh-3 | ||||||||
nob-2 | |||||||||
CELE_C38D4.6 | Accession_evidence | NDB | BX284603 | ||||||
Public_name | pal-1 | ||||||||
DB_info | Database | AceView | gene | 3F896 | |||||
WormQTL | gene | WBGene00003912 | |||||||
SignaLink | protein | WBGene00003912 | |||||||
WormFlux | gene | WBGene00003912 | |||||||
NDB | locus_tag | CELE_C38D4.6 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003912|UniProtKB=P34766 | |||||||
family | PTHR24332 | ||||||||
NCBI | gene | 175638 | |||||||
RefSeq | protein | NM_001393326.1 | |||||||
NM_001267992.4 | |||||||||
NM_001026038.7 | |||||||||
SwissProt | UniProtAcc | P34766 | |||||||
UniProt_GCRP | UniProtAcc | P34766 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:33 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | pal | ||||||||
Allele (71) | |||||||||
Legacy_information | See also e2091 | ||||||||
[C.elegansII] e2091 : adult males lack V6-derived rays, alae extend into tail region; V6 lineage transformed into V1-V4; cell autonomous action;variable additional defects, some embryonic lethality.OA3: mu13 (similar to e2091), ct224 (pka nob-2, lethal with arrest at hatching, severely deformed posterior, deletion null), ct281. Cloned: 1.25 and 1.45 kb transcripts, encode homeoprotein (pka ceh-3) with similarity to Drosophila caudal, mouse cdx-1. [Waring and Kenyon 1991; Waring et al. 1992; CF; BW] | |||||||||
Strain (12) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (32) | |||||||||
Ortholog (38) | |||||||||
Paralog | WBGene00003779 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | pal-1 encodes a homeodomain protein that is the C. elegans Caudal ortholog; PAL-1 is required maternally and embryonically for specification of the C and D posterior blastomere fates and thus, for proper bodywall muscle and hypodermal development during embryogenesis; PAL-1 is also required postembryonically for fate specification of the posterior V6 neuroectoblast during male tail development; in regulating embryonic bodywall muscle specification, PAL-1 binds to an enhancer element in the promoter of hlh-1, the sole C. elegans MRF family member, to positively regulate hlh-1 transcription; PAL-1 is expressed in posterior blastomeres beginning at the four-cell stage of embryogenesis and its expression continues during embryogenesis in posterior-derived tissues and cells undergoing movement or forming midline structures; pal-1 is subject to both transcriptional and translational regulation. | Paper_evidence | WBPaper00001409 | |||||
WBPaper00002573 | |||||||||
WBPaper00003428 | |||||||||
WBPaper00004312 | |||||||||
WBPaper00004499 | |||||||||
WBPaper00013507 | |||||||||
WBPaper00032967 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 27 Apr 2009 00:00:00 | ||||||||
Automated_description | Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate commitment; embryonic pattern specification; and positive regulation of DNA-templated transcription. Located in condensed nuclear chromosome. Expressed in several structures, including ABprpppppaa; enteric muscle; epithelial cell; oocyte; and tail spike. Human ortholog(s) of this gene implicated in Barrett's esophagus. Is an ortholog of human CDX1 (caudal type homeobox 1) and CDX2 (caudal type homeobox 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9206 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1806) | ||||
Molecular_info | Corresponding_CDS | C38D4.6a | |||||||
C38D4.6b | |||||||||
C38D4.6c | |||||||||
Corresponding_CDS_history | C38D4.6:wp52 | ||||||||
Corresponding_transcript (5) | |||||||||
Other_sequence (24) | |||||||||
Associated_feature (30) | |||||||||
Gene_product_binds | WBsf028060 | ||||||||
WBsf047529 | |||||||||
WBsf047531 | |||||||||
WBsf132694 | |||||||||
WBsf132695 | |||||||||
Transcription_factor | WBTranscriptionFactor000142 | ||||||||
Experimental_info (11) | |||||||||
Map_info | Map | III | Position | -2.46048 | Error | 0.0149 | |||
Well_ordered | |||||||||
Positive | Positive_clone | AC10 | |||||||
C38D4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
W05E6 | |||||||||
Mapping_data | 2_point | 4229 | |||||||
6036 | |||||||||
Multi_point | 1482 | ||||||||
1483 | |||||||||
2081 | |||||||||
2083 | |||||||||
2085 | |||||||||
2086 | |||||||||
2800 | |||||||||
3179 | |||||||||
Landmark_gene | |||||||||
Reference (204) | |||||||||
Remark | testing swap around with kP101. from -2.58 to -2.829 | ||||||||
Method | Gene |