WormBase Tree Display for Gene: WBGene00003877

WBGene00003877 SMap: S_parent: Sequence: K04E7
  Identity: Version: 2
    Name: CGC_name: pept-1 Person_evidence: WBPerson2603
            WBPerson861
      Sequence_name: K04E7.2
      Molecular_name: K04E7.2
        K04E7.2.1
        CE25039
      Other_name: pep-2
        opt-2
        CELE_K04E7.2 Accession_evidence: NDB BX284606
      Public_name: pept-1
    DB_info: Database: AceView gene XH79
        WormQTL gene WBGene00003877
        WormFlux gene WBGene00003877
        NDB locus_tag CELE_K04E7.2
        Panther gene CAEEL|WormBase=WBGene00003877|UniProtKB=Q21219
          family PTHR11654
        NCBI gene 180919
        RefSeq protein NM_076686.7
        SwissProt UniProtAcc Q21219
        UniProt_GCRP UniProtAcc Q21219
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Apr 2009 13:55:02 WBPerson9133 Name_change: CGC_name: pept-1
                Other_name: opt-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pept
    Allele (85)
    Possibly_affected_by: WBVar02157263
    Strain: WBStrain00036075
      WBStrain00003894
    RNASeq_FPKM (74)
    GO_annotation (46)
    Ortholog (46)
    Paralog: WBGene00003876 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003878 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: pept-1 encodes a low affinity/high capacity oligopeptide transporter; pept-1 is required for uptake of intact peptides from the intestine and thus for normal development, growth, and reproduction; genetic studies indicate that pept-1 interacts with both the daf-2/insulin- and let-363/TOR-signaling pathways to regulate lifespan and with the daf-2 pathway to influence stress response; PEPT-1 is expressed in the intestine where it localizes to the apical membrane. Paper_evidence: WBPaper00006186
            WBPaper00024423
          Curator_confirmed: WBPerson1843
          Date_last_updated: 05 Nov 2009 00:00:00
      Automated_description: Enables dipeptide transmembrane transporter activity. Involved in several processes, including chemical homeostasis; nitrogen compound transport; and regulation of signal transduction. Located in apical plasma membrane. Expressed in intestine. Used to study obesity. Is an ortholog of human SLC15A1 (solute carrier family 15 member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00034742
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Sep 2021 00:00:00
  Models_disease_asserted: WBDOannot00000178
  Molecular_info: Corresponding_CDS: K04E7.2
    Corresponding_transcript: K04E7.2.1
    Other_sequence (23)
    Associated_feature: WBsf662881
      WBsf978975
      WBsf1005576
      WBsf1023101
      WBsf235837
  Experimental_info: RNAi_result (49)
    Expr_pattern: Expr1421
      Expr8048
      Expr8049
      Expr10732
      Expr1026620
      Expr1031825
      Expr1153607
      Expr2014823
      Expr2033057
      Marker28
    Drives_construct (23)
    Construct_product: WBCnstr00004990
      WBCnstr00009194
      WBCnstr00013078
      WBCnstr00014892
      WBCnstr00016252
      WBCnstr00018325
      WBCnstr00037949
    Regulate_expr_cluster: WBPaper00045460:Co-expression_Cluster_1
      WBPaper00045460:Co-expression_Cluster_2
      WBPaper00045460:Co-expression_Cluster_3
      WBPaper00045460:pept-1(lg601)_downregulated
      WBPaper00045460:pept-1(lg601)_upregulated
    Antibody: WBAntibody00002276
    Microarray_results (20)
    Expression_cluster (236)
    Interaction: WBInteraction000003022
      WBInteraction000003023
      WBInteraction000004120
      WBInteraction000005204
      WBInteraction000005205
      WBInteraction000005206
      WBInteraction000005207
      WBInteraction000005614
      WBInteraction000028742
      WBInteraction000029599
      WBInteraction000036941
      WBInteraction000039699
      WBInteraction000047592
      WBInteraction000049199
      WBInteraction000052668
      WBInteraction000122797
      WBInteraction000134080
      WBInteraction000139404
      WBInteraction000146163
      WBInteraction000165927
      WBInteraction000166151
      WBInteraction000178929
      WBInteraction000189269
      WBInteraction000190170
      WBInteraction000195384
      WBInteraction000203894
      WBInteraction000211841
      WBInteraction000216316
      WBInteraction000219354
      WBInteraction000220696
      WBInteraction000223959
      WBInteraction000231004
      WBInteraction000231553
      WBInteraction000235126
      WBInteraction000246099
      WBInteraction000246100
      WBInteraction000265501
      WBInteraction000269154
      WBInteraction000322247
      WBInteraction000322777
      WBInteraction000338262
      WBInteraction000352247
      WBInteraction000385907
      WBInteraction000389511
      WBInteraction000398140
      WBInteraction000406990
      WBInteraction000429973
      WBInteraction000450841
      WBInteraction000466237
      WBInteraction000505035
      WBInteraction000519721
      WBInteraction000519722
      WBInteraction000519723
      WBInteraction000519724
      WBInteraction000519725
      WBInteraction000519726
      WBInteraction000519727
      WBInteraction000519728
      WBInteraction000519729
      WBInteraction000519730
      WBInteraction000519731
      WBInteraction000519735
      WBInteraction000519736
      WBInteraction000519737
      WBInteraction000519780
      WBInteraction000519781
      WBInteraction000519782
      WBInteraction000519783
      WBInteraction000519784
      WBInteraction000519785
      WBInteraction000519797
      WBInteraction000519798
      WBInteraction000519799
      WBInteraction000519800
      WBInteraction000519801
      WBInteraction000519802
      WBInteraction000519803
      WBInteraction000519804
      WBInteraction000519805
      WBInteraction000519806
      WBInteraction000519807
      WBInteraction000519808
      WBInteraction000519809
      WBInteraction000519810
      WBInteraction000519811
      WBInteraction000519812
      WBInteraction000519813
      WBInteraction000519814
      WBInteraction000519815
      WBInteraction000519816
      WBInteraction000519817
      WBInteraction000519818
      WBInteraction000519819
      WBInteraction000519820
      WBInteraction000519821
      WBInteraction000519822
      WBInteraction000519823
      WBInteraction000519824
      WBInteraction000519902
      WBInteraction000523966
      WBInteraction000523967
      WBInteraction000525366
      WBInteraction000536825
      WBInteraction000536826
      WBInteraction000536827
      WBInteraction000536828
      WBInteraction000536829
      WBInteraction000536830
      WBInteraction000536831
      WBInteraction000536832
      WBInteraction000564140
      WBInteraction000570985
      WBInteraction000571051
      WBInteraction000580213
  Map_info: Map: X Position: -2.89742 Error: 0.002559
    Positive: Positive_clone: K04E7 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (57)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene