WormBase Tree Display for Gene: WBGene00003778

WBGene00003778 SMap: S_parent: Sequence: C15H9
  Identity: Version: 1
    Name: CGC_name: nnt-1
      Sequence_name: C15H9.1
      Molecular_name: C15H9.1
        C15H9.1.1
        CE08176
      Other_name: CELE_C15H9.1 Accession_evidence: NDB BX284606
      Public_name: nnt-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:33 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nnt
    Allele (91)
    Strain: WBStrain00001362
      WBStrain00031635
      WBStrain00035473
      WBStrain00035476
    RNASeq_FPKM (74)
    GO_annotation (12)
    Ortholog (32)
    Structured_description: Concise_description: nnt-1 encodes a proton-pumping nicotinamide nucleotide transhydrogenase predicted to be mitochondrial. Paper_evidence: WBPaper00004424
            WBPaper00005552
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable NAD(P)+ transhydrogenase activity and NADP binding activity. Predicted to be involved in NADPH regeneration. Located in mitochondrion. Expressed in ganglia; intestine; pharyngeal-intestinal valve; and somatic nervous system. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Is an ortholog of human NNT (nicotinamide nucleotide transhydrogenase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0080620 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:7863)
  Molecular_info: Corresponding_CDS: C15H9.1
    Corresponding_transcript: C15H9.1.1
    Other_sequence (79)
    Associated_feature: WBsf662865
      WBsf662866
      WBsf1005484
      WBsf1005485
      WBsf1023060
      WBsf235801
      WBsf235802
      WBsf235803
  Experimental_info: RNAi_result: WBRNAi00010802 Inferred_automatically: RNAi_primary
      WBRNAi00002414 Inferred_automatically: RNAi_primary
      WBRNAi00040628 Inferred_automatically: RNAi_primary
      WBRNAi00078166 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram12
      Expr5271
      Expr10728
      Expr11937
      Expr1015420
      Expr1031767
      Expr1144685
      Expr2014342
      Expr2032583
    Drives_construct: WBCnstr00002251
      WBCnstr00002252
      WBCnstr00007832
      WBCnstr00019739
      WBCnstr00035871
    Construct_product: WBCnstr00035871
    Regulate_expr_cluster: WBPaper00025185:nnt-1_downregulated
      WBPaper00025185:nnt-1_upregulated
    Antibody: WBAntibody00001862
    Microarray_results (19)
    Expression_cluster: WBPaper00029359_1168
      WBPaper00029359_1197
      WBPaper00029359_1225
      WBPaper00029359_1258
      WBPaper00029359_1291
      WBPaper00029359_1494
      WBPaper00029359_1546
      WBPaper00031040:Cluster_3
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032976:non_compensated_genes
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:hypodermis_embryo_enriched
      WBPaper00038213:E.coli(LF82)_72h_upregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038289:oocyte_protein
      WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
      WBPaper00040285:H2S_12hr_downregulated
      WBPaper00041954:ethanol_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00044128:daf-2(e1370)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045401:N.parisii_40h_downregulated
      WBPaper00045521:Spermatogenic
      WBPaper00045618:fbf-1_upregulated
      WBPaper00045774:clk-1_upregulated
      WBPaper00046024:sleep_upregulated_oscillating
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048690:hermaphrodite-Z1-Z4-daughter_enriched
      WBPaper00048690:hermaphrodite-Z1-Z4_enriched
      WBPaper00048690:male-Z1-Z4-daughter_enriched
      WBPaper00048690:male-Z1-Z4_enriched
      WBPaper00048923:Aging_regulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:daf-16(mu86)_downregulated_neuron
      WBPaper00048988:neuron_expressed
      WBPaper00049018:swsn-2.2(RNAi)_downregulated
      WBPaper00049635:dop-1(vs100)_downregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00050109:rBmTX14_upregulated
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050686:glp-1(e2141)_downregulated
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050887:Lactoferrin_upregulated
      WBPaper00050990:hypodermis_enriched
      WBPaper00050990:hypodermis_expressed
      WBPaper00051305:vit-2(ac3)_downregulated
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053020:sid-3(ok973)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053318:Aging_upregulated_mRNA_N2
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_3h-NaCl
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055386:eat-2(ad465)_downregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056165:mina-1(ok1521)_downregulated_transcript
      WBPaper00056165:MINA-1_interacting_mRNA
      WBPaper00056169:rrf-3(pk1426)_downregulated_L1
      WBPaper00056218:daf-16(mu86)_upregulated_Day3
      WBPaper00056218:daf-16(mu86)_upregulated_Day5
      WBPaper00056218:daf-16(mu86)_upregulated_Day7
      WBPaper00056284:ints-11(RNAi)_downregulated
      WBPaper00056330:glycine_downregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056826:SGP_biased
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00057265:metaformin_upregulated_OP50-MR
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059728:5ug_cholesterol_upregulated
      WBPaper00059728:20ug_cholesterol_upregulated
      WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
      WBPaper00059735:glucose_upregulated_N2
      WBPaper00059754:C.neoformans_H99_upregulated
      WBPaper00059754:E.faecalis_OG1RF_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059816:crh-1(n3315)_downrgulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
      WBPaper00060921:cat-2(e1112)_downregulated
      WBPaper00060921:tdc-1(n3419)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061007:X.citri_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061106:endu-2(tm4977)_upregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:hyp4_hyp5_hyp6
      WBPaper00061340:hyp7_AB_lineage
      WBPaper00061340:hyp7_C_lineage
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061527:C32F10.4-D1086.2
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061613:human-alpha-Synuclein(A53T)_upregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061853:osm-3(dh441)_downregulated
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062156:jmjd-1.2(zr1010)_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_downregulated_N2
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062497:xpf-1(tm2842)_upregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00062684:pathogen_upregulated_N2
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064229:B.thuringiensis-Cry5Ba_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064632:daf-2(e1370)_upregulated_intestine
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064788:ketamine_upregulated
      WBPaper00064871:hypoxia_downregulated_F3
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00065005:sams-3(RNAi)_upregulated
      WBPaper00065005:sams-4(RNAi)_upregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065392:Lb.plantarum_downregulated
      WBPaper00065392:Lb.reuteri_downregulated
      WBPaper00065578:gcn-1(nc40)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065841:23_0
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066005:RAGA-1_degradation_neuronal_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      cgc4489_group_12
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025032:cluster_12
      WBPaper00025185:nnt-1_downregulated
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00027342:alpha-Synuclein(A53T)_downregulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:hlh_1_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00032948:StarveUp2
      WBPaper00034739:TreatmentAffectedGenes
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00036286:Pattern_F
      WBPaper00036383:ash-2_L3_regulated
      WBPaper00038172:crh-1null_down_regulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038304:octr-1_regulated
      WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
      WBPaper00040963:Q200_up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:jun-1_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00044091:Bpseudomallei_repressed_8h
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045015:nhr-25(RNAi)_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00046083:pmk-1(km25)_OP50_downregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00047021:MWCNT_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:daf-16(mgDF50)_regulated_Starved
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(122_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
      [cgc5976]:class_1
    Interaction (45)
  Map_info: Map: X Position: -3.68202 Error: 0.025708
    Positive: Positive_clone: C15H9 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4540
    Pseudo_map_position
  Reference (13)
  Remark: Sequence connection from [Arkblad E]. krb 13/11/01
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene