WormBase Tree Display for Gene: WBGene00003670
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| WBGene00003670 | Evidence | Paper_evidence | WBPaper00003754 | ||||
|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | H10E21 | ||||
| Identity (6) | |||||||
| Gene_info | Biotype | SO:0001217 | |||||
| Gene_class | nhr | ||||||
| Allele (234) | |||||||
| Strain | WBStrain00008405 | ||||||
| WBStrain00034506 | |||||||
| WBStrain00034508 | |||||||
| WBStrain00034509 | |||||||
| WBStrain00004023 | |||||||
| WBStrain00030244 | |||||||
| RNASeq_FPKM (74) | |||||||
| GO_annotation (17) | |||||||
| Ortholog (30) | |||||||
| Paralog (225) | |||||||
| Structured_description | Concise_description | nhr-80 encodes a nuclear hormone receptor, expressed in the intestine,that regulates expression of the delta-9 desaturases FAT-5/-6/-7, andthus regulates fatty acid metabolism; NHR-80 is fully required for anyexpression of FAT-7, full expression of FAT-5/-6, viability in theabsence of FAT-6, and transcriptional hyperactivation of fat-7 in theabsence of FAT-6, and for a fully normal adult lifespan; nhr-80 isexpressed robustly in the intestine during larval and adult stages ofdevelopment, with some expression also seen in head muscles; nhr-80 isspecific to nematodes, being a divergent ortholog of HNF4 with manyparalogs in C. elegans; nhr-80(tm1011) mutants, like nhr-49 mutants,have an increased ration of saturated 18:0 fatty acids tomonounsaturated 18:1 ones (4.6 instead of 2.2); nhr-80(tm1011) mutantsare viable and fertile and have no increase in fat storage, but doublefat-6(tm331);nhr-80(tm1011) mutants, (or fat-6(tm331) mutants subjectedto nhr-80(RNAi), are synthetically lethal unless cultured on mediasupplemented with desaturated fatty acids. | Paper_evidence | WBPaper00003754 | |||
| WBPaper00027749 | |||||||
| Curator_confirmed | WBPerson1843 | ||||||
| WBPerson567 | |||||||
| Date_last_updated | 12 Mar 2007 00:00:00 | ||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Involved in determination of adult lifespan; positive regulation of metabolic process; and post-embryonic development. Located in nucleus. Expressed in head; intestine; muscle cell; somatic nervous system; and tail neurons. | Paper_evidence | WBPaper00065943 | ||||
| Curator_confirmed | WBPerson324 | ||||||
| WBPerson37462 | |||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
| Molecular_info | Corresponding_CDS | H10E21.3a | |||||
| H10E21.3b | |||||||
| Corresponding_transcript | H10E21.3a.1 | ||||||
| H10E21.3b.1 | |||||||
| Other_sequence (23) | |||||||
| Associated_feature | WBsf650778 | ||||||
| WBsf226071 | |||||||
| Transcription_factor | WBTranscriptionFactor000724 | ||||||
| Experimental_info | RNAi_result (24) | ||||||
| Expr_pattern | Expr1184 | ||||||
| Expr9203 | |||||||
| Expr1028389 | |||||||
| Expr1153088 | |||||||
| Expr2014232 | |||||||
| Expr2032473 | |||||||
| Drives_construct | WBCnstr00008319 | ||||||
| WBCnstr00010136 | |||||||
| WBCnstr00013793 | |||||||
| WBCnstr00018585 | |||||||
| WBCnstr00035958 | |||||||
| Construct_product | WBCnstr00008319 | ||||||
| WBCnstr00010136 | |||||||
| WBCnstr00013793 | |||||||
| WBCnstr00016839 | |||||||
| WBCnstr00018585 | |||||||
| WBCnstr00035958 | |||||||
| Regulate_expr_cluster | WBPaper00040998:nhr-80_regulated | ||||||
| Microarray_results (24) | |||||||
| Expression_cluster (97) | |||||||
| Interaction (27) | |||||||
| WBProcess | WBbiopr:00000121 | ||||||
| Map_info | Map | III | Position | -27.2207 | Error | 0.030731 | |
| Positive | Positive_clone | H10E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
| H10E21 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||
| Reference | WBPaper00003754 | ||||||
| WBPaper00027309 | |||||||
| WBPaper00027749 | |||||||
| WBPaper00033689 | |||||||
| WBPaper00034500 | |||||||
| WBPaper00037402 | |||||||
| WBPaper00038251 | |||||||
| WBPaper00039827 | |||||||
| WBPaper00040998 | |||||||
| WBPaper00042471 | |||||||
| WBPaper00043031 | |||||||
| WBPaper00043037 | |||||||
| WBPaper00044527 | |||||||
| WBPaper00045571 | |||||||
| WBPaper00045873 | |||||||
| WBPaper00046225 | |||||||
| WBPaper00047560 | |||||||
| WBPaper00048196 | |||||||
| WBPaper00048993 | |||||||
| WBPaper00052391 | |||||||
| WBPaper00055252 | |||||||
| WBPaper00057030 | |||||||
| WBPaper00057952 | |||||||
| WBPaper00059191 | |||||||
| WBPaper00059578 | |||||||
| WBPaper00060051 | |||||||
| WBPaper00061653 | |||||||
| WBPaper00062322 | |||||||
| WBPaper00062349 | |||||||
| WBPaper00062388 | |||||||
| WBPaper00062492 | |||||||
| WBPaper00062625 | |||||||
| WBPaper00063942 | |||||||
| WBPaper00064071 | |||||||
| WBPaper00064284 | |||||||
| WBPaper00064543 | |||||||
| WBPaper00064820 | |||||||
| Picture | WBPicture0000013097 | ||||||
| WBPicture0000013098 | |||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
| Method | Gene |
