WormBase Tree Display for Gene: WBGene00003479

WBGene00003479 Evidence: Paper_evidence: WBPaper00006051
    Person_evidence: WBPerson170
  SMap: S_parent: Sequence: Y39H10A
  Identity: Version: 1
    Name: CGC_name: mtm-9 Person_evidence: WBPerson170
      Sequence_name: Y39H10A.3
      Molecular_name: Y39H10A.3a
        Y39H10A.3a.1
        CE26073
        Y39H10A.3b
        CE36959
        Y39H10A.3b.1
      Other_name: cup-10
        Y39H10A.b Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        Y39H10A.f Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y39H10A.3 Accession_evidence: NDB BX284605
      Public_name: mtm-9
    DB_info: Database: AceView gene 5E227
        WormQTL gene WBGene00003479
        WormFlux gene WBGene00003479
        NDB locus_tag CELE_Y39H10A.3
        Panther gene CAEEL|WormBase=WBGene00003479|UniProtKB=Q965W9
          family PTHR10807
        NCBI gene 178790
        RefSeq protein NM_182367.6
            NM_071637.7
        SwissProt UniProtAcc Q965W9
        UniProt_GCRP UniProtAcc Q965W9
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mtm
    Allele (128)
    Strain: WBStrain00033216
      WBStrain00008043
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog (41)
    Paralog: WBGene00003475 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003476 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003477 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021683 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003478 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mtm-9 encodes a catalytically inactive myotubularin lipid phosphatase orthologous to human MTMR9 (OMIM:606260) that affects phosphoinositide 3-phosphate localization, and whose mutation blocks endocytosis by the coelomocytes of C. elegans; MTM-9 is believed to function as part of a complex with MTM-6A and it is predominantly localized to the coelomocyte cytoplasm, with some localization to the membrane. Paper_evidence: WBPaper00004883
            WBPaper00006306
            WBPaper00037794
            WBPaper00044932
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 02 Apr 2014 00:00:00
      Automated_description: Enables phosphatase binding activity. Involved in pinocytosis and regulation of cell migration. Located in cytosol and plasma membrane. Expressed in several structures, including CAN; PDE; coelomocyte; epithelial cell; and vulva. Used to study centronuclear myopathy. Is an ortholog of human MTMR9 (myotubularin related protein 9). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14717 Homo sapiens Paper_evidence: WBPaper00006306
          Curator_confirmed: WBPerson324
          Date_last_updated: 15 Oct 2018 00:00:00
    Disease_relevance: Mutations in the human myotubularin family of lipid phosphatases, are associated with myotubular myopathy (associated gene, MTM1) and Charcot-Marie-Tooth disease, a group of progressive demyelinating neuropathies that affect the peripheral nerves (associated gene, MTMR2); studies in C. elegans indicate that, elegans mtm-9 together with mtm-6, and possibly other myotubularins, act in the arf-6/ARF6, rme-1/Ehd pathway for endocytosis, suggesting that disruptions in this endocytic pathway may be one of the causes leading to disease. Homo sapiens Curator_confirmed: WBPerson324
          Date_last_updated: 05 Mar 2014 00:00:00
  Models_disease_asserted: WBDOannot00000278
  Molecular_info: Corresponding_CDS: Y39H10A.3a
      Y39H10A.3b
    Corresponding_CDS_history: Y39H10A.3:wp126
      Y39H10A.3b:wp102
    Corresponding_transcript: Y39H10A.3a.1
      Y39H10A.3b.1
    Other_sequence (70)
    Associated_feature: WBsf718290
      WBsf231602
      WBsf231603
  Experimental_info: RNAi_result: WBRNAi00097617 Inferred_automatically: RNAi_primary
      WBRNAi00065085 Inferred_automatically: RNAi_primary
      WBRNAi00056293 Inferred_automatically: RNAi_primary
      WBRNAi00091925 Inferred_automatically: RNAi_primary
      WBRNAi00020434 Inferred_automatically: RNAi_primary
      WBRNAi00065086 Inferred_automatically: RNAi_primary
      WBRNAi00091926 Inferred_automatically: RNAi_primary
      WBRNAi00097613 Inferred_automatically: RNAi_primary
      WBRNAi00097619 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2826
      Expr9224
      Expr1016199
      Expr1031595
      Expr1159780
      Expr2013813
      Expr2032053
    Drives_construct: WBCnstr00010974
      WBCnstr00013810
      WBCnstr00036089
    Construct_product: WBCnstr00010974
      WBCnstr00036089
    Microarray_results (30)
    Expression_cluster (132)
    Interaction: WBInteraction000031311
      WBInteraction000113006
      WBInteraction000354169
      WBInteraction000374757
      WBInteraction000388237
      WBInteraction000501484
      WBInteraction000562612
      WBInteraction000562613
    WBProcess: WBbiopr:00000073
  Map_info: Map: V Position: -8.01374 Error: 0.016451
    Positive: Positive_clone: Y39H10A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3957
        4277
      Pos_neg_data: 10779
  Reference (12)
  Method: Gene