WormBase Tree Display for Gene: WBGene00003474

WBGene00003474 SMap: S_parent: Sequence: T08G5
  Identity: Version: 1
    Name: CGC_name: mtl-2 Person_evidence: WBPerson1414
      Sequence_name: T08G5.10
      Molecular_name: T08G5.10
        T08G5.10.1
        CE25109
      Other_name: met-II Accession_evidence: EMBL X53245
              D17365
        CELE_T08G5.10 Accession_evidence: NDB BX284605
      Public_name: mtl-2
    DB_info: Database: AceView gene 5O498
        WormQTL gene WBGene00003474
        WormFlux gene WBGene00003474
        NDB locus_tag CELE_T08G5.10
        NCBI gene 179899
        RefSeq protein NM_074081.9
        SwissProt UniProtAcc P17512
        UniProt_GCRP UniProtAcc P17512
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:32 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mtl
    Allele (15)
    Legacy_information: [C.elegansII] NMK. Encodes 63 aa metallothionein; accumulates after exposure to CdCl2. mtl-1:lacZ expressed in intestine after cadmium treatment or heat shock. [Freedman et al. 1993]
    Strain: WBStrain00005079
      WBStrain00005080
      WBStrain00005081
      WBStrain00005101
      WBStrain00040877
      WBStrain00035525
    RNASeq_FPKM (74)
    GO_annotation: 00039557
      00039558
      00106045
      00106046
      00106267
      00106268
    Ortholog: WBGene00027389 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
      WBGene00027390 Caenorhabditis briggsae From_analysis: OrthoMCL
            Inparanoid_8
            WormBase-Compara
      WBGene00151369 Caenorhabditis brenneri From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00271681 Caenorhabditis briggsae From_analysis: WormBase-Compara
      FL83_06429 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_020394 Caenorhabditis remanei From_analysis: WormBase-Compara
      chrV_pilon.g16404 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00057046 Caenorhabditis remanei From_analysis: WormBase-Compara
    Structured_description: Concise_description: mtl-2 encodes one of two C. elegans metallothioneins, small, cysteine-rich, metal-binding proteins; MTL-2 functions in metal detoxification and homeostasis and stress adaptation; in addition, mtl-2 plays a role in regulating growth and fertility; mtl-2 expression is induced in larval and adult intestinal cells following exposure to cadmium or heat shock; MTL-2 intestinal expression is dependent upon ELT-2, an intestine-specific GATA-type transcription factor; mtl-2 is downregulated by DAF-16 in daf-2 mutants. Paper_evidence: WBPaper00001688
            WBPaper00003700
            WBPaper00004299
            WBPaper00004381
            WBPaper00005295
            WBPaper00005976
            WBPaper00028866
          Curator_confirmed: WBPerson1843
          Date_last_updated: 07 May 2007 00:00:00
      Automated_description: Enables cadmium ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to heat. Expressed in intestinal cell and intestine. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T08G5.10
    Corresponding_transcript: T08G5.10.1
    Other_sequence: CBC00932_1
      CBC01514_2
      FD517649.1
      CBC01514_1
      CJC01860_1
      CSC00487_1
      FD517704.1
    Associated_feature: WBsf653359
      WBsf919637
      WBsf919638
      WBsf982357
      WBsf982358
      WBsf234895
  Experimental_info: RNAi_result (11)
    Expr_pattern: Expr1380
      Expr1509
      Expr3079
      Expr1020789
      Expr1156496
      Expr2013808
      Expr2032048
    Drives_construct (15)
    Construct_product: WBCnstr00007972
      WBCnstr00007973
      WBCnstr00011119
      WBCnstr00036093
    Microarray_results (19)
    Expression_cluster: WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00033444:BacteriaDiet_regulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:intestine_larva_SelectivelyEnriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00038061:aldicarb_upregulated
      WBPaper00038118:aak-2(gt33)_downregulated
      WBPaper00038118:stress_downregulated_N2
      WBPaper00038168:lin-15B(n744)_downregulated
      WBPaper00038168:lin-35_downregulated
      WBPaper00038438:E.faecalis_24hr_downregulated_RNAseq
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray
      WBPaper00040209:B.thuringiensis_downregulated_MY15
      WBPaper00040209:B.thuringiensis_downregulated_MY18
      WBPaper00040560:hpl-2_embryo_downregulated
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044030:nhr-8(hd117)_downregulated
      WBPaper00044037:eat-2_downregulated
      WBPaper00044316:CH3HgCl_0.75uM_downregulated
      WBPaper00044316:CH3HgCl_2.0uM_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044316:HgCl2_2.0uM_upregulated
      WBPaper00044316:HgCl2_7.5uM_upregulated
      WBPaper00044316:HgCl2_20uM_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045316:prg-1_downregulated_L3
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00046128:ethanol_downregulated
      WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
      WBPaper00046741:Garlic-Extract_downregulated_mRNA
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048423:LP133_LF21_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_upregulated
      WBPaper00049266:NaAsO2-Stress_regulated_N2
      WBPaper00049266:NaAsO2-Stress_regulated_trx-1(ok1449)
      WBPaper00049334:CE_intestine_enriched
      WBPaper00049368:daf-2(e1370)_downregulated
      WBPaper00049484:elt-2(RNAi)_downregulated_L1
      WBPaper00049484:elt-2(RNAi)_downregulated_L4
      WBPaper00049498:npr-1(ur89)_regulated_6
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050080:rbr-2(tm3141)_upregulated
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050225:flp-6(RNAi)_downregulated
      WBPaper00050234:lin-28(RNAi)_downregulated
      WBPaper00050332:skn-1(RNAi)_downregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051039:intestine_enriched
      WBPaper00051137:N.parisii-virus_downregulated_N2
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051388:Glucose-diet_downregulated
      WBPaper00051404:alg-1(gk214)_downregulated
      WBPaper00051498:zinc-reduction_downregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(icb38)_downregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster5
      WBPaper00053402:his-3(RNAi)_downregulated
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
      WBPaper00053737:Anatase-TiO2-Nanoparticles_upregulated
      WBPaper00053782:daf-2(RNAi)_oocyte_downregulated
      WBPaper00053814:OP50_vs_PY79_upregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_upregulated
      WBPaper00054872:egl-9(sa307)_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056039:efa-6(tm3124)_upregulated
      WBPaper00056090:E.faecalis_downregulated_N2
      WBPaper00056090:hpx-2(dg047)_upregulated_E.faecalis
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056275:P.aeruginosa_downregulated
      WBPaper00056284:ints-1(RNAi)_upregulated
      WBPaper00056284:ints-2(RNAi)_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056471:S.aureus-4h_downregulated_N2
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
      WBPaper00056731:human-amylin_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057265:metaformin_upregulated_OP50
      WBPaper00058665:graphene-oxide_downregulated_mRNA
      WBPaper00058711:wdr-5(ok1417)_downregulated
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00058948:npr-8(ok1439)_downregulated_PA14
      WBPaper00058948:PA14_upregulated
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059421:daf-1(m40)_downregulated
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00059739:hira-1(gk835598)_downregulated_adult
      WBPaper00059739:hira-1(gk835598)_downregulated_L4
      WBPaper00059763:neuron_expressed
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00059839:S.maltophilia_regulated
      WBPaper00059987:Wounding_downregulated
      WBPaper00060084:cco-1(RNAi)_downregulated_N2
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_non-pathogen_regulated_N2
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_downregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061007:X.citri_downregulated
      WBPaper00061045:Y56A3A.22(cck200)_upregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061424:Diet_MYb120_downregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061478:pie-1(ne4433)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:R10H10.3-T21H3.1
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:Intestine_enriched
      WBPaper00061651:M4_enriched
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062167:mbl-1(tm1563)_downregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062305:P.brevicompactum_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062347:blmp-1(tm548)_downregulated
      WBPaper00062520:qui-1(db104)_upregulated
      WBPaper00062534:fat-P-80_downregulated
      WBPaper00062534:fat-P-80_downregulated_ech-6(RNAi)
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064005:starvation_upregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064505:tamoxifen_downregulated
      WBPaper00064532:pals-22(jy3)_downregulated
      WBPaper00064727:daf-2(e1370)_downregulated
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:JU1400_N.ferruginous_regulated
      WBPaper00065158:AFD_depleted
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065749:Heat-Shock-With-Recovery_downregulated_N2
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11
      WBPaper00065841:3_0
      WBPaper00065841:3_1
      WBPaper00065841:3_2
      WBPaper00065841:3_5
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_downregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:hsf-1(RNAi)_downregulated_WT
      cgc4386_cluster_1_3
      cgc4489_group_2
      WBPaper00024393:strongly_regulated_dauer_genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026629:L2_male_enriched
      WBPaper00026980:intestine_enriched
      WBPaper00028564:CeMM_vs_NGM_upregulated
      WBPaper00028789:PA14_vs_OP50_downregulated_8hr
      WBPaper00030985:Enterococcus_faecalis_upregulated
      WBPaper00030985:Photorhabdus_luminescens_upregulated
      WBPaper00030985:Serratia_marcesens_downregulated
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00031532:Larva_Pan_Neuronal_Depleted
      WBPaper00031832:slr-2_regulated
      WBPaper00031850:mdt-15(RNAi)_downregulated
      WBPaper00032165:differentially_expressed_with_age_medoid_4
      WBPaper00034739:N2moreDR1350
      WBPaper00035479:daf-16(RNAi)_upregulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_I
      WBPaper00037113:DZN_16C_down-regulated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00040184:hcf-1down_sir-2.1down_daf-2nc
      WBPaper00040426:CYD-1_CDK-4_downregulated
      WBPaper00040426:CYE-1_CDK-2AF_downregulated
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
      WBPaper00040823:alg-1(gk214)_upregulated
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HF_11d_2.0mM_Up
      WBPaper00041002:HQ_3d_0.2mM_Down
      WBPaper00041174:environmental
      WBPaper00041174:environmental_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041906:I-3690_vs_OP50_3d
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00044091:Bpseudomallei_regulated_qPCR-confirmed
      WBPaper00044091:Bpseudomallei_repressed_12h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045374:Benzene_upregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
      WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053550:daf-19(m86)_upregulated_L1
      WBPaper00055899:2,4-Dinitroanisole_regulated
    Interaction (39)
    WBProcess: WBbiopr:00000039
      WBbiopr:00000050
      WBbiopr:00000053
      WBbiopr:00000096
  Map_info: Map: V Position: 6.07164 Error: 0.009738
    Positive: Positive_clone: CR#MT2
        T08G5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4288
        4500
    Pseudo_map_position
  Reference (74)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene