WormBase Tree Display for Gene: WBGene00003417

WBGene00003417 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: Y41C4A
  Identity: Version: 1
    Name: CGC_name: mrt-2 Person_evidence: WBPerson261
      Sequence_name: Y41C4A.14
      Molecular_name: Y41C4A.14
        Y41C4A.14.1
        CE29376
        Y41C4A.14.2
      Other_name: hpr-1
        CELE_Y41C4A.14 Accession_evidence: NDB BX284603
      Public_name: mrt-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mrt
    Allele (132)
    Strain: WBStrain00031909
      WBStrain00004639
    RNASeq_FPKM (74)
    GO_annotation (26)
    Ortholog (34)
    Structured_description: Concise_description: mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; mrt-2 functions in the germline to maintain chromosomal integrity, and promote cell cycle arrest in mitotic germ cells and apoptosis in meiotic germ cells in response to genotoxic agents (DNA damage); mrt-2 mutations result in progressive telomere loss, chromosome fusion, and aneuploidy, eventually leading to germline mortality; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins. Paper_evidence: WBPaper00003353
            WBPaper00003886
            WBPaper00003984
            WBPaper00005237
            WBPaper00005597
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Jun 2011 00:00:00
      Automated_description: Predicted to enable 3'-5' exonuclease activity and damaged DNA binding activity. Involved in DNA damage response and telomere maintenance via telomerase. Predicted to be located in nucleus. Predicted to be part of checkpoint clamp complex. Is an ortholog of human RAD1 (RAD1 checkpoint DNA exonuclease). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y41C4A.14
    Corresponding_transcript: Y41C4A.14.1
      Y41C4A.14.2
    Other_sequence: JI459899.1
      CBC00612_1
      CR07641
      HG06632
      EY472449.1
      GP01754
      OF00726
      GE638976.1
      HCC04778_1
      MA03330
    Associated_feature: WBsf994482
      WBsf225855
  Experimental_info: RNAi_result: WBRNAi00064153 Inferred_automatically: RNAi_primary
      WBRNAi00022481 Inferred_automatically: RNAi_primary
      WBRNAi00006768 Inferred_automatically: RNAi_primary
      WBRNAi00064152 Inferred_automatically: RNAi_primary
      WBRNAi00067556 Inferred_automatically: RNAi_primary
      WBRNAi00064105 Inferred_automatically: RNAi_primary
      WBRNAi00056356 Inferred_automatically: RNAi_primary
      WBRNAi00027845 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1016257
      Expr1031584
      Expr1159841
      Expr2013762
      Expr2031997
    Drives_construct: WBCnstr00005145
    Construct_product: WBCnstr00005145
    Microarray_results (20)
    Expression_cluster (108)
    Interaction: WBInteraction000001040
      WBInteraction000002294
      WBInteraction000002775
      WBInteraction000002906
      WBInteraction000003837
      WBInteraction000007010
      WBInteraction000008923
      WBInteraction000009734
      WBInteraction000009741
      WBInteraction000028493
      WBInteraction000029178
      WBInteraction000029180
      WBInteraction000029640
      WBInteraction000029641
      WBInteraction000029642
      WBInteraction000029745
      WBInteraction000029785
      WBInteraction000029786
      WBInteraction000029787
      WBInteraction000030086
      WBInteraction000030206
      WBInteraction000030797
      WBInteraction000031282
      WBInteraction000031283
      WBInteraction000031284
      WBInteraction000031285
      WBInteraction000031286
      WBInteraction000031287
      WBInteraction000031288
      WBInteraction000031289
      WBInteraction000031290
      WBInteraction000031291
      WBInteraction000031292
      WBInteraction000031293
      WBInteraction000031294
      WBInteraction000031295
      WBInteraction000031296
      WBInteraction000031297
      WBInteraction000031298
      WBInteraction000031300
      WBInteraction000031301
      WBInteraction000031302
      WBInteraction000031304
      WBInteraction000031306
      WBInteraction000031307
      WBInteraction000031308
      WBInteraction000031309
      WBInteraction000031310
      WBInteraction000051783
      WBInteraction000051785
      WBInteraction000052611
      WBInteraction000052612
      WBInteraction000109066
      WBInteraction000109195
      WBInteraction000115347
      WBInteraction000125393
      WBInteraction000125395
      WBInteraction000125397
      WBInteraction000125485
      WBInteraction000126969
      WBInteraction000132253
      WBInteraction000132628
      WBInteraction000132757
      WBInteraction000138817
      WBInteraction000139065
      WBInteraction000142729
      WBInteraction000153560
      WBInteraction000157344
      WBInteraction000165549
      WBInteraction000166131
      WBInteraction000168304
      WBInteraction000173501
      WBInteraction000183550
      WBInteraction000191256
      WBInteraction000204330
      WBInteraction000217892
      WBInteraction000217899
      WBInteraction000217945
      WBInteraction000218006
      WBInteraction000218040
      WBInteraction000218054
      WBInteraction000218057
      WBInteraction000218058
      WBInteraction000218198
      WBInteraction000218208
      WBInteraction000218234
      WBInteraction000220017
      WBInteraction000241003
      WBInteraction000248614
      WBInteraction000262623
      WBInteraction000266998
      WBInteraction000273777
      WBInteraction000275533
      WBInteraction000276301
      WBInteraction000282145
      WBInteraction000312604
      WBInteraction000348865
      WBInteraction000355534
      WBInteraction000370701
      WBInteraction000373297
      WBInteraction000376018
      WBInteraction000384240
      WBInteraction000384310
      WBInteraction000384503
      WBInteraction000389998
      WBInteraction000409932
      WBInteraction000410153
      WBInteraction000416834
      WBInteraction000426965
      WBInteraction000431258
      WBInteraction000439708
      WBInteraction000440983
      WBInteraction000441133
      WBInteraction000458737
      WBInteraction000501814
      WBInteraction000507927
      WBInteraction000509418
      WBInteraction000509419
      WBInteraction000509772
      WBInteraction000509777
      WBInteraction000509781
      WBInteraction000509785
      WBInteraction000509790
      WBInteraction000509792
      WBInteraction000509800
      WBInteraction000509808
      WBInteraction000509809
      WBInteraction000513228
      WBInteraction000514235
      WBInteraction000514236
      WBInteraction000514239
      WBInteraction000514240
      WBInteraction000514241
      WBInteraction000514242
      WBInteraction000514243
      WBInteraction000514244
      WBInteraction000514245
      WBInteraction000514247
      WBInteraction000514248
      WBInteraction000514249
      WBInteraction000514250
      WBInteraction000515883
      WBInteraction000515884
      WBInteraction000520835
      WBInteraction000521796
      WBInteraction000523992
      WBInteraction000539471
      WBInteraction000539831
      WBInteraction000539832
      WBInteraction000539833
      WBInteraction000539834
      WBInteraction000539835
      WBInteraction000539836
      WBInteraction000539837
      WBInteraction000539838
      WBInteraction000539839
      WBInteraction000539840
      WBInteraction000539841
      WBInteraction000539842
      WBInteraction000539843
      WBInteraction000539844
      WBInteraction000539845
      WBInteraction000539846
      WBInteraction000539849
      WBInteraction000539855
      WBInteraction000539880
      WBInteraction000539929
      WBInteraction000539930
      WBInteraction000539936
      WBInteraction000541136
      WBInteraction000548361
      WBInteraction000548398
      WBInteraction000550932
      WBInteraction000550934
      WBInteraction000550935
      WBInteraction000550936
      WBInteraction000550937
      WBInteraction000550938
      WBInteraction000550939
      WBInteraction000550940
      WBInteraction000550941
      WBInteraction000550942
      WBInteraction000550943
      WBInteraction000550944
      WBInteraction000550945
      WBInteraction000550946
      WBInteraction000550947
      WBInteraction000550948
      WBInteraction000550949
      WBInteraction000550950
      WBInteraction000550955
      WBInteraction000550992
      WBInteraction000556226
      WBInteraction000556378
      WBInteraction000558085
      WBInteraction000558086
      WBInteraction000558087
    WBProcess: WBbiopr:00000014
      WBbiopr:00000091
  Map_info: Map: III Position: 12.0743 Error: 0.051368
    Positive: Positive_clone: Y41C4A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4239
        4497
    Pseudo_map_position
  Reference (76)
  Picture: WBPicture0000013091
  Remark: Sequence connection from [Ahmed S, Hodgkin J]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene