WormBase Tree Display for Gene: WBGene00003408
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| WBGene00003408 | SMap | S_parent | Sequence | F57C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mrp-2 | Person_evidence | WBPerson490 | |||||
| Sequence_name | F57C12.4 | ||||||||
| Molecular_name | F57C12.4 | ||||||||
| F57C12.4.1 | |||||||||
| CE26370 | |||||||||
| Other_name | CELE_F57C12.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | mrp-2 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mrp | ||||||||
| Allele (127) | |||||||||
| Legacy_information | [C.elegansII] NMK. Encodes predicted protein similar to human MRP. [NL] | ||||||||
| mrp for Multidrug Resistance-associated Protein family. mrp-2 is F57C12.4, encodes 1475aa protein, 48% identical to human MRP1. No mutants known. | |||||||||
| Strain | WBStrain00032405 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Contained_in_operon | CEOPX154 | ||||||||
| Ortholog (49) | |||||||||
| Paralog | WBGene00000477 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003407 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003411 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003410 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003409 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003414 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003413 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00003412 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state. | Paper_evidence | WBPaper00002619 | |||||
| WBPaper00004424 | |||||||||
| WBPaper00005859 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including bile duct disease (multiple); leukemia (multiple); and lung disease (multiple). Is an ortholog of human ABCC3 (ATP binding cassette subfamily C member 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (13) | ||||||||
| Molecular_info | Corresponding_CDS | F57C12.4 | |||||||
| Corresponding_transcript | F57C12.4.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf034317 | ||||||||
| WBsf670064 | |||||||||
| WBsf1003807 | |||||||||
| WBsf1003808 | |||||||||
| WBsf1022144 | |||||||||
| WBsf1022145 | |||||||||
| WBsf236931 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00097976 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00048850 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015883 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram310 | ||||||||
| Expr6241 | |||||||||
| Expr1012747 | |||||||||
| Expr1031577 | |||||||||
| Expr1152599 | |||||||||
| Expr2013687 | |||||||||
| Expr2031922 | |||||||||
| Drives_construct | WBCnstr00002777 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (186) | |||||||||
| Interaction (48) | |||||||||
| Map_info | Map | X | Position | -19.6347 | Error | 0.009197 | |||
| Positive | Positive_clone | F57C12 | Person_evidence | WBPerson4545 | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Pseudo_map_position | |||||||||
| Reference (15) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
