WormBase Tree Display for Gene: WBGene00003394
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| WBGene00003394 | SMap | S_parent | Sequence | T07H6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mom-1 | Person_evidence | WBPerson498 | |||||
| Sequence_name | T07H6.2 | ||||||||
| Molecular_name | T07H6.2 | ||||||||
| T07H6.2.1 | |||||||||
| CE25982 | |||||||||
| Other_name | bop-1 | ||||||||
| CELE_T07H6.2 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mom-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mom | ||||||||
| Allele (78) | |||||||||
| Legacy_information | [Downs WD] MOre Mesoderm. (Formerly referred to as bop-1.) Maternaleffect embryonic lethal in which the E blastomere makes pharyngeal andmuscle tissue (similar to MS). The cleavage plane of ABar is also altered. | ||||||||
| [C.elegansII] Mutations lead to maternal effect lethality, embryos arrest with extra pharyngeal tissue like that derived from MS; possible E to MStransformation. OA3. [JJ] | |||||||||
| Strain | WBStrain00007262 | ||||||||
| WBStrain00007263 | |||||||||
| WBStrain00007265 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (39) | |||||||||
| Ortholog (30) | |||||||||
| Paralog | WBGene00016934 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00007446 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00008806 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020115 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mom-1 encodes a putative O-acyltransferase orthologous to Drosophila PORCUPINE and human PORCN (OMIM:300651, mutated in focal dermal hypoplasia); MOM-1 functions as part of a Wnt/MAPK signaling pathway required maternally for endoderm induction in the early embryo; by orthology, MOM-1 is predicted to be a membrane-spanning endoplasmic reticulum protein that stimulates post-translational processing of Wnt signaling molecules such as MOM-2; embryonic mosaic analysis indicates that MOM-1 activity is required in the signaling cell, P2, for proper specification of endoderm, consistent with its predicted role in processing MOM-2/Wnt. | Paper_evidence | WBPaper00002870 | |||||
| WBPaper00002871 | |||||||||
| WBPaper00027263 | |||||||||
| WBPaper00031342 | |||||||||
| WBPaper00032174 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 14 Oct 2008 00:00:00 | ||||||||
| Automated_description | Predicted to enable Wnt-protein binding activity and palmitoleoyltransferase activity. Involved in several processes, including Wnt signaling pathway, regulating spindle positioning; asymmetric protein localization involved in cell fate determination; and embryonic morphogenesis. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in focal dermal hypoplasia. Is an ortholog of human PORCN (porcupine O-acyltransferase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:2120 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:17652) | ||||
| Molecular_info | Corresponding_CDS | T07H6.2 | |||||||
| Corresponding_transcript | T07H6.2.1 | ||||||||
| Associated_feature | WBsf648222 | ||||||||
| WBsf662313 | |||||||||
| WBsf982182 | |||||||||
| WBsf1005546 | |||||||||
| WBsf1005547 | |||||||||
| WBsf235825 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00068239 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00052806 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00067937 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00027830 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061878 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00018406 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00101377 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr1024093 | ||||||||
| Expr1031566 | |||||||||
| Expr1156408 | |||||||||
| Expr2013655 | |||||||||
| Expr2031889 | |||||||||
| Drives_construct | WBCnstr00036142 | ||||||||
| Construct_product | WBCnstr00036142 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (115) | |||||||||
| Interaction (24) | |||||||||
| Anatomy_function | WBbtf0745 | ||||||||
| Map_info | Map | X | Position | -3.17624 | Error | 0.035848 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T07H6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3383 | |||||||
| 3384 | |||||||||
| 3386 | |||||||||
| 3385 | |||||||||
| 4420 | |||||||||
| Reference (46) | |||||||||
| Picture | WBPicture0000013084 | ||||||||
| Method | Gene |
