WormBase Tree Display for Gene: WBGene00008806
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| WBGene00008806 | SMap | S_parent | Sequence | F14F3 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | mboa-7 | Person_evidence | WBPerson1105 | |||||
| Sequence_name | F14F3.3 | ||||||||
| Molecular_name | F14F3.3 | ||||||||
| F14F3.3.1 | |||||||||
| CE40384 | |||||||||
| Other_name | tag-289 | ||||||||
| CELE_F14F3.3 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | mboa-7 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 22 Apr 2005 11:55:18 | WBPerson2970 | Name_change | CGC_name | tag-289 | ||||
| 3 | 09 Sep 2008 12:24:31 | WBPerson2970 | Name_change | CGC_name | mboa-7 | ||||
| Other_name | tag-289 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mboa | ||||||||
| Allele (40) | |||||||||
| Strain | WBStrain00031776 | ||||||||
| WBStrain00036190 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOPX139 | ||||||||
| Ortholog (34) | |||||||||
| Paralog | WBGene00003394 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00007446 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016934 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020115 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mboa-7 encodes a lysophosphatidylinositol (LPI)-specific acyltransferase which acts on the sn-2 hydroxyl of glycerol (sn-2 LPIAT); MBOA-7 is required in vivo for the incorporation of externally supplemented polyunsaturated fatty acids (PUFAs) into the sn-2 position of phosphatidylinositol (PI), as well as for most LPIAT activity in microsomes, progression through larval development, normal egg-laying, and (with FAT-1 and FAT-4) normally rapid growth at low temperature; membrane vesicles expressing MBOA-7 or its human ortholog show elevated LPIAT activity; mboa-7 is expressed ubiquitously, throughout development from embryogenesis to adulthood, with high expression in pharyngeal muscles, body wall muscles, vulval cells, distal tip cells, intestinal cells, and adult spermatheca; residue H350 of MBOA-7 is essential for its biochemical activity in membrane vesicles; mboa-7 mutants have abnormally low levels of eicosapentaenoic acid (EPA) in the sn-2 position of PI, and fail to have their growth rescued by supplementary arachidonic acid (AA) or EPA in their diet. | Paper_evidence | WBPaper00027263 | |||||
| WBPaper00031342 | |||||||||
| WBPaper00032174 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 14 Oct 2008 00:00:00 | ||||||||
| Automated_description | Enables O-acyltransferase activity. Involved in egg-laying behavior; nematode larval development; and phosphatidylinositol biosynthetic process. Located in intracellular membrane-bounded organelle. Expressed in several structures, including hermaphrodite distal tip cell; intestine; pharyngeal muscle cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 57. Is an ortholog of human MBOAT7 (membrane bound O-acyltransferase domain containing 7). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0081219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15505) | ||||
| Molecular_info | Corresponding_CDS | F14F3.3 | |||||||
| Corresponding_CDS_history | F14F3.3:wp163 | ||||||||
| Corresponding_transcript | F14F3.3.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf654340 | ||||||||
| WBsf670029 | |||||||||
| WBsf670963 | |||||||||
| WBsf1006733 | |||||||||
| WBsf237874 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00102766 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00013292 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00007982 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062743 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062744 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00044617 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3304 | ||||||||
| Expr8323 | |||||||||
| Expr1013283 | |||||||||
| Expr1033843 | |||||||||
| Expr1148583 | |||||||||
| Expr2013439 | |||||||||
| Expr2031673 | |||||||||
| Drives_construct | WBCnstr00005353 | ||||||||
| WBCnstr00011301 | |||||||||
| WBCnstr00037863 | |||||||||
| Construct_product | WBCnstr00005353 | ||||||||
| WBCnstr00037863 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (108) | |||||||||
| Interaction (40) | |||||||||
| Map_info | Map | X | Position | 2.22476 | Error | 0.000244 | |||
| Positive | Positive_clone | F14F3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5168 | |||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
