WormBase Tree Display for Gene: WBGene00003243
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| WBGene00003243 | SMap | S_parent | Sequence | F10E9 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mig-10 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F10E9.6 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CELE_F10E9.6 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mig-10 | ||||||||
| DB_info | Database | AceView | gene | 3J395 | |||||
| WormQTL | gene | WBGene00003243 | |||||||
| WormFlux | gene | WBGene00003243 | |||||||
| NDB | locus_tag | CELE_F10E9.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003243|UniProtKB=P34400 | |||||||
| family | PTHR11243 | ||||||||
| NCBI | gene | 176168 | |||||||
| RefSeq | protein | NM_001379826.1 | |||||||
| NM_066420.6 | |||||||||
| NM_001382935.2 | |||||||||
| SwissProt | UniProtAcc | P34400 | |||||||
| TREEFAM | TREEFAM_ID | TF317511 | |||||||
| UniProt_GCRP | UniProtAcc | P34400 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mig | ||||||||
| Allele (291) | |||||||||
| Possibly_affected_by | WBVar02157219 | ||||||||
| Legacy_information | [C.elegansII] ct41 : incomplete CAN, HSN, ALM migrations; shortened excretory canals; additional defects. Mosaic analysis indicates non-autonomy, possible hypodermal focus. OA1: e2527. Cloned: encodes predicted 650 aa protein with similarity to human Grb7, Grb10, including pleckstrin homology domain. [Desai et al. 1988; LK] | ||||||||
| Strain | WBStrain00001485 | ||||||||
| WBStrain00002915 | |||||||||
| WBStrain00003479 | |||||||||
| WBStrain00033874 | |||||||||
| WBStrain00032605 | |||||||||
| WBStrain00003959 | |||||||||
| WBStrain00051958 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (38) | |||||||||
| Structured_description | Concise_description | mig-10 encodes proteins that contain, from N- to C-terminus, an RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and a proline-rich motif, and that are homologous to the vertebrate RIAM, lamellopodin, and Grb7, Grb10, and Grb14 cytoplasmic adaptor proteins; during development, mig-10 activity is required for cell migration and for outgrowth of axons and excretory cell canals; in regulating axon outgrowth, MIG-10 likely functions downstream of UNC-6/Netrin and SLT-1/Slit and in concert with UNC-34, with which it interacts in vitro; MIG-10 also physically interacts with ABI-1 (Abelson interactor-1); mig-10::gfp reporter fusions are expressed in neurons as well as in pharyngeal and intestinal tissue; when expressed in tissue culture cells, a MIG-10::GFP fusion protein colocalizes with F-actin and promotes lamellipodia formation. | Paper_evidence | WBPaper00001304 | |||||
| WBPaper00002766 | |||||||||
| WBPaper00027185 | |||||||||
| WBPaper00027328 | |||||||||
| WBPaper00041596 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Nov 2012 00:00:00 | ||||||||
| Automated_description | Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F10E9.6a | |||||||
| F10E9.6b | |||||||||
| F10E9.6c | |||||||||
| Corresponding_CDS_history | F10E9.6a:wp113 | ||||||||
| F10E9.6b:wp113 | |||||||||
| Corresponding_transcript | F10E9.6a.1 | ||||||||
| F10E9.6a.2 | |||||||||
| F10E9.6a.3 | |||||||||
| F10E9.6b.1 | |||||||||
| F10E9.6c.1 | |||||||||
| Other_sequence (28) | |||||||||
| Associated_feature (66) | |||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern (27) | |||||||||
| Drives_construct | WBCnstr00001004 | ||||||||
| WBCnstr00003428 | |||||||||
| WBCnstr00004230 | |||||||||
| WBCnstr00011701 | |||||||||
| WBCnstr00013113 | |||||||||
| WBCnstr00016488 | |||||||||
| WBCnstr00017477 | |||||||||
| WBCnstr00017478 | |||||||||
| WBCnstr00017479 | |||||||||
| Construct_product (12) | |||||||||
| Microarray_results (45) | |||||||||
| Expression_cluster (181) | |||||||||
| Interaction (65) | |||||||||
| Anatomy_function | WBbtf0493 | ||||||||
| WBbtf0494 | |||||||||
| WBbtf0815 | |||||||||
| Map_info | Map | III | Position | -0.346394 | Error | 0.001792 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F10E9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point (11) | ||||||||
| Pos_neg_data | 4231 | ||||||||
| 4232 | |||||||||
| 4975 | |||||||||
| Reference (58) | |||||||||
| Method | Gene |
