mig-10 encodes proteins that contain, from N- to C-terminus, an RA-like (Ras association) domain, a PH (pleckstrin homology) domain, and a proline-rich motif, and that are homologous to the vertebrate RIAM, lamellopodin, and Grb7, Grb10, and Grb14 cytoplasmic adaptor proteins; during development, mig-10 activity is required for cell migration and for outgrowth of axons and excretory cell canals; in regulating axon outgrowth, MIG-10 likely functions downstream of UNC-6/Netrin and SLT-1/Slit and in concert with UNC-34, with which it interacts in vitro; MIG-10 also physically interacts with ABI-1 (Abelson interactor-1); mig-10::gfp reporter fusions are expressed in neurons as well as in pharyngeal and intestinal tissue; when expressed in tissue culture cells, a MIG-10::GFP fusion protein colocalizes with F-actin and promotes lamellipodia formation.
Enables SH3 domain binding activity. Involved in several processes, including cell migration; cell projection organization; and egg-laying behavior. Located in neuronal cell body membrane; plasma membrane bounded cell projection; and presynaptic cytosol. Part of filamentous actin. Expressed in hermaphrodite gonad; neurons; and tail. Is an ortholog of human RAPH1 (Ras association (RalGDS/AF-6) and pleckstrin homology domains 1).