WormBase Tree Display for Gene: WBGene00003225
expand all nodes | collapse all nodes | view schema
| WBGene00003225 | SMap | S_parent | Sequence | T07C4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mev-1 | Person_evidence | WBPerson286 | |||||
| Sequence_name | T07C4.7 | ||||||||
| Molecular_name | T07C4.7a | ||||||||
| T07C4.7a.1 | |||||||||
| CE00598 | |||||||||
| T07C4.7b | |||||||||
| CE50785 | |||||||||
| T07C4.7b.1 | |||||||||
| Other_name | cyt-1 | ||||||||
| sdhc-1 | Person_evidence | WBPerson205 | |||||||
| CELE_T07C4.7 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | mev-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 19 Jul 2006 13:37:01 | WBPerson2970 | Name_change | Other_name | sdhc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mev | ||||||||
| Reference_allele | WBVar00088257 | ||||||||
| Allele (36) | |||||||||
| Possibly_affected_by | WBVar02154060 | ||||||||
| Legacy_information | [Ishii N, Hartman PS] mev for MEthyl Viologen (paraquat) resistance abnormal. Four-fold increase in paraquat sensitivity, hypersensitive to high oxygen concentration, reduced broodsize, reduced lifespan, increased age-associated fluorescence, rare supernumerary divisions in gut cells. | ||||||||
| [C.elegansII] kn1 : four-fold increase in paraquat sensitivity; hypersensitive to high oxygen concentration; reduced broodsize, reduced lifespan, increased age-associated fluorescence; rare supernumerary divisions in gut cells. [Honda et al. 1993; TK; TM] | |||||||||
| [Ishii N] mev-1 encodes succinate dehydrogenase cytochrome b, pka cyt-1. kn1 is G71E missense. | |||||||||
| [C.elegansII] NMK. Transcripts 2.1 kb (cyt-1 + ced-9) and0.75 kb; encodes 182 aa presumptive cytochrome b560;3' end overlaps ced-9, shared regulation. [Hengartner and Horvitz 1994; MT; WS] | |||||||||
| Strain (19) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Contained_in_operon | CEOP3666 | ||||||||
| Ortholog (37) | |||||||||
| Structured_description | Concise_description | mev-1 encodes the C. elegans ortholog of the succinate dehydrogenase cytochrome b560 subunit, an integral membrane protein that is a subunit of mitochondrial respiratory chain complex II (succinate-CoQ oxidoreductase); MEV-1 is required for oxidative phosphorylation, and mev-1 mutations result abnormal energy metabolism and increased sensitivity to oxidative stress and pathogen infection; a mev-1 deletion mutation also has a shortened lifespan; MEV-1 localizes to mitochondria. | Paper_evidence | WBPaper00001342 | |||||
| WBPaper00003157 | |||||||||
| WBPaper00005920 | |||||||||
| WBPaper00003366 | |||||||||
| WBPaper00035985 | |||||||||
| WBPaper00046210 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 23 Aug 2016 00:00:00 | ||||||||
| Automated_description | Contributes to succinate dehydrogenase (ubiquinone) activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and regulation of response to oxidative stress. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Carney-Stratakis syndrome; gastrointestinal stromal tumor; and paraganglioma. Is an ortholog of human SDHC (succinate dehydrogenase complex subunit C). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||
| DOID:0080533 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||||
| DOID:0050773 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||||
| DOID:9253 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10682) | ||||||
| Disease_relevance | C. elegans is used as a model system to study the molecular mechanisms underlying diabetic hyperglycemia-induced reduction in life-span; studies in the mev-1 mutant strain of C. elegans, which carries a mutation in the cytochrome b subunit of succinate dehydrogenase and displays increased mitochondrial reactive oxygen species (ROS) generation, in analogy to the situation observed in insulin-resistance, indicate that an impaired proteosomal degradation system and accumulation of misfolded/unfolded proteins underlies glucose induced life-span reduction. | Homo sapiens | Paper_evidence | WBPaper00041961 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 11 Mar 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T07C4.7a | |||||||
| T07C4.7b | |||||||||
| Corresponding_transcript | T07C4.7a.1 | ||||||||
| T07C4.7b.1 | |||||||||
| Other_sequence (104) | |||||||||
| Associated_feature | WBsf645557 | ||||||||
| WBsf659493 | |||||||||
| WBsf659494 | |||||||||
| WBsf225708 | |||||||||
| Experimental_info | RNAi_result (28) | ||||||||
| Expr_pattern | Expr4391 | ||||||||
| Expr1027219 | |||||||||
| Expr1031524 | |||||||||
| Expr1156340 | |||||||||
| Expr2013540 | |||||||||
| Expr2031774 | |||||||||
| Drives_construct | WBCnstr00000780 | ||||||||
| WBCnstr00036176 | |||||||||
| WBCnstr00042214 | |||||||||
| Construct_product | WBCnstr00000780 | ||||||||
| WBCnstr00036176 | |||||||||
| WBCnstr00042214 | |||||||||
| Regulate_expr_cluster | WBPaper00046217:mev-1(kn1)_downregulated | ||||||||
| WBPaper00046217:mev-1(kn1)_upregulated | |||||||||
| Antibody | WBAntibody00000642 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (121) | |||||||||
| Interaction (95) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000065 | |||||||||
| Map_info | Map | III | Position | 2.348 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | T07C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Negative | Negative_clone | C38H2 | |||||||
| Mapping_data | Multi_point | 1752 | |||||||
| 1753 | |||||||||
| 1754 | |||||||||
| 1755 | |||||||||
| 1756 | |||||||||
| 1757 | |||||||||
| 1824 | |||||||||
| 2407 | |||||||||
| 3547 | |||||||||
| Reference (248) | |||||||||
| Remark | Rescue data communicated by Hartman PS | ||||||||
| extracted from Ishii et al. (1998) | |||||||||
| Positive_clone is based on transformation rescue, mutant sequence [Ishii N, Hartman PS][030403 ck1] | |||||||||
| Negative_clone is based on no rescue [Ishii N, Hartman PS][030403 ck1] | |||||||||
| [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.32414) | |||||||||
| Method | Gene |
