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WormBase Tree Display for Gene: WBGene00003166

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Name Class

WBGene00003166SMapS_parentSequenceCHROMOSOME_X
IdentityVersion1
NameCGC_namemec-2Person_evidenceWBPerson95
Sequence_nameF14D12.4
Molecular_name (51)
Other_nameCELE_F14D12.4Accession_evidenceNDBBX284606
Public_namemec-2
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:31WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classmec
Allele (374)
Legacy_informationSee also e75, e1084, e1514
[C.elegansII] u8amb : touch insensitive; lethargic. ES2. ME?. OA>50: e75 (recessive, ME3), u7cs, e1084 (probable null), e1514, e1608dm, u284sd, etc. Alleles vary in phenotype from weak recessive to strong dominant Mec; complex complementation. Cloned: encodes predicted 440 aa protein with central similarity to human stomatin (65% identity over 247 aa). mec-2:lacZ expressed in cell bodies and processes of touch cells, some other neurons.??? [Chalfie and Au 1989; Huang et al. 1995; TU]
StrainWBStrain00002820
WBStrain00037747
WBStrain00004463
WBStrain00004092
RNASeq_FPKM (74)
GO_annotation (26)
Ortholog (36)
ParalogWBGene00006761Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006068Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006065Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006741Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006064Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006063Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006067Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006066Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006061Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionThe mec-2 gene encodes a stomatin homolog required to sense gentle mechanical stimuli (e.g. touch) along the body wall.Paper_evidenceWBPaper00005127
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables cholesterol binding activity. Involved in positive regulation of multicellular organismal process and response to mechanical stimulus. Located in neuron projection membrane. Expressed in sensory neurons. Used to study nephrotic syndrome. Is an ortholog of human STOM (stomatin).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1184Homo sapiensPaper_evidenceWBPaper00044961
Accession_evidenceOMIM600995
Curator_confirmedWBPerson324
Date_last_updated25 Sep 2018 00:00:00
Models_disease_in_annotationWBDOannot00000328
Molecular_infoCorresponding_CDS (17)
Corresponding_transcript (17)
Other_sequence (86)
Associated_feature (17)
Experimental_infoRNAi_resultWBRNAi00027647Inferred_automaticallyRNAi_primary
WBRNAi00013263Inferred_automaticallyRNAi_primary
WBRNAi00044585Inferred_automaticallyRNAi_primary
Expr_pattern (18)
Drives_constructWBCnstr00003347
WBCnstr00004794
WBCnstr00010333
WBCnstr00011303
WBCnstr00011304
WBCnstr00036204
WBCnstr00042668
WBCnstr00042669
Construct_productWBCnstr00010333
WBCnstr00011303
WBCnstr00036204
AntibodyWBAntibody00000792
WBAntibody00000793
WBAntibody00001354
WBAntibody00001686
WBAntibody00002696
Microarray_results (40)
Expression_cluster (164)
InteractionWBInteraction000000363
WBInteraction000000364
WBInteraction000000383
WBInteraction000000384
WBInteraction000000385
WBInteraction000000386
WBInteraction000000483
WBInteraction000000800
WBInteraction000000801
WBInteraction000001969
WBInteraction000003266
WBInteraction000003357
WBInteraction000005106
WBInteraction000005107
WBInteraction000005108
WBInteraction000009911
WBInteraction000028235
WBInteraction000028236
WBInteraction000028237
WBInteraction000028366
WBInteraction000029628
WBInteraction000029810
WBInteraction000121250
WBInteraction000126232
WBInteraction000126233
WBInteraction000126234
WBInteraction000126372
WBInteraction000126488
WBInteraction000126740
WBInteraction000127000
WBInteraction000142095
WBInteraction000161777
WBInteraction000161778
WBInteraction000166055
WBInteraction000166056
WBInteraction000169482
WBInteraction000170295
WBInteraction000170299
WBInteraction000176275
WBInteraction000176276
WBInteraction000179374
WBInteraction000184473
WBInteraction000185291
WBInteraction000213698
WBInteraction000219286
WBInteraction000219653
WBInteraction000228720
WBInteraction000229295
WBInteraction000245358
WBInteraction000254571
WBInteraction000258416
WBInteraction000268601
WBInteraction000279979
WBInteraction000296899
WBInteraction000300435
WBInteraction000353182
WBInteraction000403506
WBInteraction000413741
WBInteraction000432353
WBInteraction000438417
WBInteraction000447249
WBInteraction000450171
WBInteraction000464304
WBInteraction000468271
WBInteraction000472261
WBInteraction000472591
WBInteraction000474700
WBInteraction000504766
WBInteraction000521603
WBInteraction000524576
WBInteraction000524577
WBInteraction000541567
WBInteraction000541651
WBInteraction000549791
WBInteraction000549960
WBInteraction000549961
WBInteraction000550313
WBInteraction000550314
WBInteraction000550950
WBInteraction000561338
WBInteraction000561340
WBProcessWBbiopr:00000002
Map_infoMapXPosition-4.70552Error0.075755
Well_ordered
PositivePositive_cloneF14D12Inferred_automaticallyFrom sequence, transcript, pseudogene data
W05G12RemarkAlternative clone not in the golden path of clones.
NegativeOutside_rearrmcDf2
Mapping_dataMulti_point (11)
Pos_neg_data940
1832
3193
500
10696
Reference (113)
RemarkUpdated positive clone to correspond to the sequenced clone instead of just W05G12
MethodGene