[C.elegansII] e2518spo : no phenotype in hermaphrodite, male tail very swollen, rays indistinct. ME0. Vancouver wild isolate KR314 is naturally homozygous for e2518. [CB]
mab-23 encodes a DNA binding transcription factor of the DM (DOUBLESEX/MAB-3) class that is required for morphogenesis of the posterior hypodermis, spicules, and proctodeum in male tails, for the patterning of posterior male sensory neurons, and for normal turning during male mating; mab-23 interacts with egl-5 and with a TGF-beta-related signaling pathway, while having functions independent of mab-3.
Predicted to enable metal ion binding activity and sequence-specific DNA binding activity. Involved in negative regulation of gene expression; neuron fate determination; and regulation of reproductive process. Located in nucleus. Expressed in several structures, including U cell; hermaphrodite gonad; neurons; tail hypodermis; and ventral nerve cord.