WormBase Tree Display for Gene: WBGene00003086
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| WBGene00003086 | Evidence | Paper_evidence | WBPaper00006348 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y37A1B | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | lst-4 | Person_evidence | WBPerson220 | |||||
| Sequence_name | Y37A1B.2 | ||||||||
| Molecular_name (24) | |||||||||
| Other_name | CELE_Y37A1B.2 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | lst-4 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lst | ||||||||
| Allele (189) | |||||||||
| Strain | WBStrain00002373 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (46) | |||||||||
| Paralog | WBGene00004927 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00006503 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00013354 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lst-4 encodes multiple isoforms of a sorting nexin that are the sole C. elegans members of the SNX9 family of sorting nexins ; activity of the SH3 domain-containing LST-4 isoforms is required for regulation of phagosome maturation during apoptotic cell corpse clearance, specifically for regulating phagosomal fusion with endosomes and lysosomes; LST-4 physically interacts with the DYN-1/dynamin GTPase that is also required for phagosomal maturation; LST-4::GFP reporter fusions localizes to phagosomal surfaces as well as to highly dynamic membrane tubules that extend from phagosomes; murine SNX33 is able to rescue the cell corpse engulfment defects seen in lst-4 mutant animals. | Paper_evidence | WBPaper00037878 | |||||
| WBPaper00038320 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 Apr 2011 00:00:00 | ||||||||
| Automated_description | Enables enzyme binding activity; phosphatidylinositol phosphate binding activity; and protein self-association. Involved in execution phase of apoptosis and phagosome-lysosome fusion involved in apoptotic cell clearance. Located in early phagosome. Expressed in embryonic cell; gonad; and gonadal sheath cell. Is an ortholog of human SNX18 (sorting nexin 18) and SNX33 (sorting nexin 33). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y37A1B.2a | |||||||
| Y37A1B.2b | |||||||||
| Y37A1B.2c | |||||||||
| Y37A1B.2d | |||||||||
| Y37A1B.2e | |||||||||
| Y37A1B.2f | |||||||||
| Y37A1B.2g | |||||||||
| Y37A1B.2h | |||||||||
| Corresponding_transcript | Y37A1B.2a.1 | ||||||||
| Y37A1B.2b.1 | |||||||||
| Y37A1B.2c.1 | |||||||||
| Y37A1B.2d.1 | |||||||||
| Y37A1B.2e.1 | |||||||||
| Y37A1B.2f.1 | |||||||||
| Y37A1B.2g.1 | |||||||||
| Y37A1B.2h.1 | |||||||||
| Other_sequence (23) | |||||||||
| Associated_feature (13) | |||||||||
| Experimental_info | RNAi_result (16) | ||||||||
| Expr_pattern | Chronogram537 | ||||||||
| Expr9196 | |||||||||
| Expr11026 | |||||||||
| Expr1024570 | |||||||||
| Expr1031461 | |||||||||
| Expr1159383 | |||||||||
| Expr2013298 | |||||||||
| Expr2031529 | |||||||||
| Drives_construct | WBCnstr00003023 | ||||||||
| WBCnstr00008234 | |||||||||
| WBCnstr00013786 | |||||||||
| WBCnstr00017670 | |||||||||
| WBCnstr00017671 | |||||||||
| WBCnstr00017704 | |||||||||
| Construct_product | WBCnstr00008225 | ||||||||
| WBCnstr00008234 | |||||||||
| WBCnstr00017670 | |||||||||
| WBCnstr00017671 | |||||||||
| WBCnstr00017704 | |||||||||
| WBCnstr00020786 | |||||||||
| WBCnstr00020787 | |||||||||
| WBCnstr00040476 | |||||||||
| Microarray_results (54) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (41) | |||||||||
| WBProcess | WBbiopr:00000014 | ||||||||
| WBbiopr:00000015 | |||||||||
| Map_info | Map | IV | Position | 11.3643 | Error | 0.015352 | |||
| Positive | Positive_clone | Y37A1B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (22) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
