| WBGene00003052 | SMap | S_parent | Sequence | DY3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lmn-1 |
| | | Sequence_name | DY3.2 |
| | | Molecular_name | DY3.2 |
| | | | DY3.2.1 |
| | | | CE15746 |
| | | Other_name | Lam1 | Accession_evidence | EMBL | X74027 |
| | | | CELE_DY3.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | lmn-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lmn |
| | Allele (48) |
| | Strain | WBStrain00026339 |
| | | WBStrain00026341 |
| | | WBStrain00026343 |
| | | WBStrain00040720 |
| | | WBStrain00002790 |
| | | WBStrain00026345 |
| | | WBStrain00034808 |
| | Component_of_genotype | WBGenotype00000131 |
| | | WBGenotype00000150 |
| | RNASeq_FPKM (74) |
| | GO_annotation (36) |
| | Ortholog (49) |
| | Paralog (12) |
| | Structured_description | Concise_description | lmn-1 encodes the sole C. elegans nuclear lamin; lmn-1 is an essential gene that is required for a number of nuclear processes, including chromatin organization, cell cycle progression, chromosome segregation, and nuclear pore complex spacing; LMN-1 is also required for nuclear envelope localization of EMR-1/Emerin during early development; LMN-1 localizes to the nuclear periphery of all cell types except sperm, and in embryonic and some adult cells is visible in the nuclear interior; LMN-1 binds mitotic chromosomes and histone H2A in a manner that requires its predicted nuclear localization signal, KRRR. | Paper_evidence | WBPaper00004416 |
| | | | | | WBPaper00005158 |
| | | | | | WBPaper00028870 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 24 Feb 2009 00:00:00 |
| | | Automated_description | Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including cellular localization; determination of adult lifespan; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:3911 | Homo sapiens | Paper_evidence | WBPaper00032926 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 24 May 2018 00:00:00 |
| | | DOID:11726 | Homo sapiens | Paper_evidence | WBPaper00040258 |
| | | | | | WBPaper00038510 |
| | | | | Accession_evidence | OMIM | 181350 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 26 Jul 2023 00:00:00 |
| | | DOID:0050557 | Homo sapiens | Paper_evidence | WBPaper00040268 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 04 Feb 2013 00:00:00 |
| | Potential_model (25) |
| Models_disease_in_annotation | WBDOannot00000297 |
| Models_disease_asserted | WBDOannot00000298 |
| | WBDOannot00000531 |
| | WBDOannot00000541 |
| | WBDOannot00001395 |
| Molecular_info (4) |
| Experimental_info | RNAi_result (42) |
| | Expr_pattern (13) |
| | Drives_construct (13) |
| | Construct_product (17) |
| | Regulate_expr_cluster | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00059378:lmn-1(Y59C)_downregulated |
| | | WBPaper00059378:lmn-1(Y59C)_upregulated |
| | Antibody (13) |
| | Microarray_results (23) |
| | Expression_cluster | WBPaper00026640:Development_Group_IV |
| | | WBPaper00026640:embryo-to-L1_upregulated |
| | | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00037047:aging_accelerated_insoluble_protein |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00044128:DietaryRestriction_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_upregulated_Day5 |
| | | WBPaper00044746:aging_upregulated_Day10 |
| | | WBPaper00044746:aging_upregulated_HeatShock |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045460:pept-1(lg601)_upregulated |
| | | WBPaper00045486:starvation_downregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046217:clk-1(qm30)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00048644:germline_enriched |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:nucleus_specific |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_nucleus_expressed |
| | | WBPaper00051555:atm-1(gk186)_regulated_protein |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00052987:UV_upregulated_xpc-1;csb-1 |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00053810:isp-1(qm150)_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056139:gut-microbiota_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated |
| | | WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056900:ERH-2_interacting |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056997:NMAD-1_interacting |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_upregulated |
| | | WBPaper00058691:CFP-1_interacting_protein |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_downregulated |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:M_cell |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:pm8 |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:uggt-1_21889-tag-320_20312 |
| | | WBPaper00061651:Spermatheca_enriched |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064201:SNA-1_interacting |
| | | WBPaper00064201:SNA-3_interacting |
| | | WBPaper00064315:mes-3(bn199)_downregulated_EGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064789:Day12_vs_Day1_upregulated_neuron |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:25C_vs_15C_upregulated_AFD |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_3 |
| | | cgc4489_group_3 |
| | | WBPaper00025032:cluster_22 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_S.marcescens_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_ET |
| | | [cgc5767]:expression_class_ET_max(83_min) |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc5767]:expression_class_MET |
| | Interaction (170) |
| Map_info | Map | I | Position | 3.07104 | Error | 0.005882 |
| | Positive | Positive_clone | DY3 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4741 |
| | Pseudo_map_position |
| Reference (67) |
| Remark | Sequence connection based on email from Wen |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
