| WBGene00003033 | SMap | S_parent | Sequence | F34D10 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lin-48 | Person_evidence | WBPerson261 |
| | | Sequence_name | F34D10.5 |
| | | Molecular_name | F34D10.5 |
| | | | F34D10.5.1 |
| | | | CE24940 |
| | | Other_name | CELE_F34D10.5 | Accession_evidence | NDB | BX284603 |
| | | Public_name | lin-48 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Allele (56) |
| | Legacy_information | Males have abnormal spicules. There are lineage defects in B, F, U. |
| | | [C.elegansII] sy234 : males have abnormal spicules. Lineagedefects in B, F, U. [PS] |
| | Strain | WBStrain00022837 |
| | | WBStrain00030823 |
| | | WBStrain00052010 |
| | RNASeq_FPKM (74) |
| | GO_annotation (18) |
| | Ortholog (42) |
| | Paralog | WBGene00001824 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00008762 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00012385 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | lin-48 encodes a C2H2-type zinc-finger transcription factor that is orthologous to Drosophila OVO and mouse OVO1; LIN-48 is required for development of the hindgut, the male tail, and the excretory duct cell; in hindgut and male tail development, LIN-48 activity is essential for proper fate specification of the U, F, and K' blast cells and B blast cell descendants, and in excretory duct cell development, for normal duct cell morphogenesis; a LIN-48 translational reporter is expressed in the nuclei of the U, F, K, and K' blast cells, the excretory duct cell, and up to 10 cells in the head region beginning in late embryogenesis and continuing through adulthood; in addition, expression is detected in the neuronal support cells of the phasmid and labial sensory structures beginning at the late L1 larval stage; in hindgut cell specification, LIN-48 functions with EGL-38/Pax, which appears to be a direct transcriptional regulator of LIN-48 expression, and in excretory duct cell development, LIN-48 is likely under the control of the CES-2 bZip transcription factor | Paper_evidence | WBPaper00003719 |
| | | | | | WBPaper00004826 |
| | | | | | WBPaper00005413 |
| | | | | | WBPaper00006393 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 30 Jul 2004 00:00:00 |
| | | Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in anatomical structure morphogenesis and response to salt stress. Located in nucleus. Expressed in ciliated neurons; interfacial epithelial cell; intestine; labial sensillum; and tail. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Is an ortholog of human OVOL1 (ovo like transcriptional repressor 1) and OVOL2 (ovo like zinc finger 2). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:0110855 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15804) |
| Molecular_info | Corresponding_CDS | F34D10.5 |
| | Corresponding_transcript | F34D10.5.1 |
| | Other_sequence (13) |
| | Associated_feature (16) |
| | Transcription_factor | WBTranscriptionFactor000185 |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Expr2401 |
| | | Expr7538 |
| | | Expr11391 |
| | | Expr11392 |
| | | Expr12236 |
| | | Expr1026212 |
| | | Expr1031419 |
| | | Expr1150136 |
| | | Expr2013189 |
| | | Expr2031421 |
| | Drives_construct (14) |
| | Construct_product | WBCnstr00008997 |
| | | WBCnstr00009369 |
| | | WBCnstr00009370 |
| | | WBCnstr00009373 |
| | | WBCnstr00009374 |
| | | WBCnstr00009375 |
| | | WBCnstr00009376 |
| | | WBCnstr00009377 |
| | | WBCnstr00020606 |
| | | WBCnstr00036273 |
| | Microarray_results (22) |
| | Expression_cluster | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042477:rsr-2(RNAi)_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045934:wrn-1(gk99)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048926:miaserin_upregulated_adult-day3 |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053368:F.oxysporum_regulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056855:his-72(uge40)_upregulated |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059839:S.maltophilia_regulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061340:B_F_K_Kp_U_Y |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:F_U |
| | | WBPaper00061340:ILso |
| | | WBPaper00061340:Rectal_gland |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:C38C3.6-npr-7 |
| | | WBPaper00061527:ckr-1-T09B9.3 |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062497:xpf-1(tm2842)_downregulated |
| | | WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064509:static-magnetic-field_upregulated |
| | | WBPaper00064661:lpd-3(ok2138)_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_downregulated_transcript |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065841:34_0 |
| | | WBPaper00065841:34_1 |
| | | WBPaper00065841:79_2 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose |
| | | WBPaper00066110:Doxorubicin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00025032:cluster_84 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00035479:daf-16(RNAi)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:environmental_prime |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-exposed_24h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00045960:L1-L4-lethargus_upregulated |
| | | WBPaper00045960:L4-lethargus_upregulated |
| | | WBPaper00046853:AOBr_M.aeruginosa-batch-culture_upregulated |
| | | WBPaper00050407:hsp-6(RNAi)_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | Interaction (76) |
| Map_info | Map | III | Position | -4.25434 | Error | 0.001907 |
| | Positive | Inside_rearr | yDf10 |
| | | | sDf130 |
| | | Positive_clone | F34D10 | Person_evidence | WBPerson96 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | sDf121 |
| | Mapping_data | 2_point | 6152 |
| | | Multi_point | 3667 |
| | | | 3668 |
| | | Pos_neg_data | 9389 |
| | | | 9390 |
| | | | 9391 |
| Reference (48) |
| Remark | Moved from -3.41 [sdm/jah 5/99] |
| | [Johnson AD, Chamberlin HM] lin-48 = F34D10.5 |
| Method | Gene |
