| WBGene00003011 | SMap | S_parent | Sequence | CHROMOSOME_V |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | lin-25 | Person_evidence | WBPerson261 |
| | | Sequence_name | F56H9.5 |
| | | Molecular_name | F56H9.5 |
| | | | F56H9.5.1 |
| | | | CE05975 |
| | | Other_name | mdt-24 | Person_evidence | WBPerson3947 |
| | | | CELE_F56H9.5 | Accession_evidence | NDB | BX284605 |
| | | Public_name | lin-25 |
| | DB_info | Database | AceView | gene | 5N137 |
| | | | WormQTL | gene | WBGene00003011 |
| | | | SignaLink | protein | WBGene00003011 |
| | | | WormFlux | gene | WBGene00003011 |
| | | | NDB | locus_tag | CELE_F56H9.5 |
| | | | NCBI | gene | 179732 |
| | | | RefSeq | protein | NM_073761.8 |
| | | | SwissProt | UniProtAcc | Q10573 |
| | | | TREEFAM | TREEFAM_ID | TF316646 |
| | | | UniProt_GCRP | UniProtAcc | Q10573 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 12 Nov 2014 12:54:52 | WBPerson2970 | Name_change | Other_name | mdt-24 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00144008 |
| | Allele (91) |
| | Legacy_information | e1446 : adult hermaphrodite vulvaless 11% sterile. ES2. HME1. Males morphologically wildtype ME0. NA2 (n545ts (at 25x resembles e1446 at 15x 8% Vul)). |
| | | [Tuck SP] lin for lineage abnormal. Hermaphrodites are Egl |
| | | See also e1446, n545, n1062, n1063 |
| | | [C.elegansII] e1446 : adult hermaphrodite vulvaless,11% sterile. VPC all 3ary except P6.p. Suppresses lin-1, let-60(gf), not lin-12(gf).ES2. HME1. Males morphologically wildtype ME0. OA9: n545ts (at 25C resembles e1446, at 15C 8% Vul), n1063, ku78, ar90 (probable null, resembles e1446), etc. Cloned: encodes predicted 1139 aa novel protein. [Tuck and Greenwald 1995; GS] |
| | Strain | WBStrain00026528 |
| | | WBStrain00026804 |
| | | WBStrain00026902 |
| | | WBStrain00027100 |
| | | WBStrain00005521 |
| | | WBStrain00008013 |
| | | WBStrain00008017 |
| | RNASeq_FPKM (74) |
| | GO_annotation (15) |
| | Ortholog (27) |
| | Structured_description | Concise_description | lin-25 encodes a divergent homolog of the TRAP100/Med24 subunit of the Mediator complex; during development, lin-25 functions downstream of let-60 ras to regulate fate specification and differentiation of a number of cell types such as the vulval precursor cells; targets of LIN-25 activity include the lin-39 Hox gene, whose transcriptional upregulation during vulval cell fate specification is dependent upon lin-25; LIN-25 is expressed in vulval precursor cells, hypodermal seam cells, and cells in the somatic gonad; LIN-25 is detected in nuclei, but also seen in the cytoplasm. | Paper_evidence | WBPaper00003330 |
| | | | | | WBPaper00004407 |
| | | | | | WBPaper00027035 |
| | | | | | WBPaper00035311 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 03 May 2007 00:00:00 |
| | | Automated_description | Involved in defense response to Gram-positive bacterium and vulval development. Acts upstream of or within with a positive effect on cell fate specification. Located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite distal tip cell; and vulval cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F56H9.5 |
| | Corresponding_transcript | F56H9.5.1 |
| | Other_sequence | CJC16777 |
| | Associated_feature | WBsf647392 |
| | | WBsf661921 |
| | | WBsf1001624 |
| | | WBsf1020604 |
| | | WBsf232679 |
| | | WBsf232680 |
| | | WBsf232681 |
| Experimental_info | RNAi_result | WBRNAi00067753 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00095285 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00048794 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00067528 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015856 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1293 |
| | | Expr1023216 |
| | | Expr1031405 |
| | | Expr1152543 |
| | | Expr2013169 |
| | | Expr2031401 |
| | Drives_construct | WBCnstr00004617 |
| | | WBCnstr00004618 |
| | | WBCnstr00036286 |
| | Construct_product | WBCnstr00004617 |
| | | WBCnstr00004618 |
| | | WBCnstr00036286 |
| | Antibody | WBAntibody00000201 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00031040:TGF-beta_adult_downregulated |
| | | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045571:germline-ablation_downregulated |
| | | WBPaper00045729:gld-2(RNAi)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:SWSN-2.2_interacting |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:GABAergic-neuron_enriched |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053810:daf-2(e1370)_downregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00056165:MINA-1_interacting_mRNA |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061274:microgravity_upregulated |
| | | WBPaper00061340:Parent_of_hyp1V_and_ant_arc_V |
| | | WBPaper00061341:28C_48h_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061527:F08G12.1_2283-cst-1_319 |
| | | WBPaper00061651:OLL_enriched |
| | | WBPaper00061651:URA_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062193:hsf-1(RNAi)_downregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065841:55_0 |
| | | WBPaper00065841:100_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | cgc4386_cluster_5_1 |
| | | cgc4489_group_5 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025032:cluster_119 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00045263:isp-1(qm150)_upregulated |
| | | WBPaper00045263:nuo-6(qm200)_upregulated |
| | | WBPaper00045263:ProLongevity-mtROS_upregulated |
| | | WBPaper00045960:L4-lethargus_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(101_min) |
| | | [cgc5767]:expression_class_E_pi(122_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | | [cgc6390]:mixed_oogenesis-somatic |
| | Interaction (66) |
| Map_info | Map | V | Position | 4.60018 | Error | 0.006913 |
| | Well_ordered |
| | Positive | Positive_clone | F56H9 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | YSL59 |
| | Negative | Negative_clone | W05B10 |
| | Mapping_data | 2_point | 6095 |
| | | | 6096 |
| | | | 6097 |
| | | | 6098 |
| | | Multi_point (25) |
| | | Pos_neg_data | 1756 |
| | | | 6864 |
| | | | 7400 |
| Reference (69) |
| Method | Gene |
