WormBase Tree Display for Variation: WBVar00144008

WBVar00144008 Evidence: Paper_evidence: WBPaper00004407
  Name: Public_name: e1446
    Other_name: F56H9.5.1:c.2176C>T
      CE05975:p.Gln726Ter
    HGVSg: CHROMOSOME_V:g.12655433C>T
  Sequence_details: SMap: S_parent: Sequence: W05B10
    Flanking_sequences: tcaagaagaactgctagggcttatttggct aaatgaaagaaggaattcctttttggaaaa
    Mapping_target: W05B10
    Type_of_mutation: Substitution: c t Paper_evidence: WBPaper00004407
    SeqStatus: Sequenced
  Variation_type: Allele
  Origin: Species: Caenorhabditis elegans
    Strain: WBStrain00026902
    Laboratory: CB
    Status: Live
  Affects: Gene: WBGene00003011
    Transcript: F56H9.5.1 VEP_consequence: stop_gained
        VEP_impact: HIGH
        HGVSc: F56H9.5.1:c.2176C>T
        HGVSp: CE05975:p.Gln726Ter
        cDNA_position: 2208
        CDS_position: 2176
        Protein_position: 726
        Exon_number: 9/15
        Codon_change: Caa/Taa
        Amino_acid_change: Q/*
    Interactor: WBInteraction000002754
      WBInteraction000524063
      WBInteraction000524064
      WBInteraction000524065
      WBInteraction000524066
      WBInteraction000557741
  Genetics: Interpolated_map_position: V 4.60147
    Mapping_data: In_multi_point: 656
        670
        671
        672
        673
        944
        1435
  Description: Phenotype (12)
    Phenotype_not_observed: WBPhenotype:0000099 Paper_evidence: WBPaper00005344
        Curator_confirmed: WBPerson2987
        Remark: The lin-25(e1446) mutation did not induce the "2 P11.p" phenotype where the P12 cell adopts a P11 cell fate Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Variation_effect: Null: Paper_evidence: WBPaper00005344
            Curator_confirmed: WBPerson2987
        Phenotype_assay: Treatment: Vulval and P11.p phenotypes were scored in animals segregating from +/DnT1; lin-25/DnT1 or eor-1/DnT1; lin-25/DnT1 heterozygous mothers. Paper_evidence: WBPaper00005344
              Curator_confirmed: WBPerson2987
      WBPhenotype:0001024 Person_evidence: WBPerson261
        Curator_confirmed: WBPerson712
        Remark: Males morphologically wildtype Person_evidence: WBPerson261
            Curator_confirmed: WBPerson712
      WBPhenotype:0001278 Paper_evidence: WBPaper00057074
        Curator_confirmed: WBPerson712
        Remark: neurons did not show a loss in unc-25::GFP expression Paper_evidence: WBPaper00057074
            Curator_confirmed: WBPerson712
        Image: WBPicture0000014913 Paper_evidence: WBPaper00057074
            Curator_confirmed: WBPerson712
        EQ_annotations: Anatomy_term: WBbt:0005027 PATO:0000460 Paper_evidence: WBPaper00057074
                Curator_confirmed: WBPerson712
            WBbt:0005021 PATO:0000460 Paper_evidence: WBPaper00057074
                Curator_confirmed: WBPerson712
  Reference: WBPaper00027035
    WBPaper00005344
    WBPaper00024311
    WBPaper00000762
    WBPaper00014385
    WBPaper00057074
  Method: Substitution_allele