WormBase Tree Display for Gene: WBGene00002993
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| WBGene00002993 | SMap | S_parent | Sequence | F59G1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-4 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F59G1.6 | ||||||||
| Molecular_name | F59G1.6 | ||||||||
| F59G1.6a | |||||||||
| F59G1.6b | |||||||||
| Other_name | CELE_F59G1.6 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | lin-4 | ||||||||
| DB_info | Database | SignaLink | mirna | cel-lin-4 | |||||
| NDB | locus_tag | CELE_F59G1.6 | |||||||
| NCBI | gene | 266860 | |||||||
| RefSeq | protein | NR_000799.2 | |||||||
| RNAcentral | URSid | URS00001E2999 | |||||||
| URS0000278C03 | |||||||||
| URS0000779DBB | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001265 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00143592 | ||||||||
| Allele (12) | |||||||||
| Legacy_information | e912pdi : heterochronic retarded adult hermaphrodites long abnormal movement vulvaless lack adult cuticle ES3 (adult) ES1 (larvae); HME0 (20x)/HME1 (15x) adult males lack copulatory structures ME0. NA1 (rare mutation). | ||||||||
| See also e912, n408, n409, n410 | |||||||||
| [C.elegansII] e912pdi : heterochronic, retarded adult hermaphrodites long abnormal movement vulvaless lack adult cuticle ES3 (adult) ES1 (larvae); HME0 (20C)/HME1 (15C) adult males lack copulatory structures ME0. OA1: ma161 (resembles e912). Cloned: encodes two small RNAs with nocoding potential. [Lee et al. 1993; Wightman et al. 1993; GR; VT] | |||||||||
| Strain | WBStrain00026764 | ||||||||
| WBStrain00026863 | |||||||||
| WBStrain00027055 | |||||||||
| WBStrain00027229 | |||||||||
| WBStrain00027586 | |||||||||
| WBStrain00040213 | |||||||||
| WBStrain00004403 | |||||||||
| WBStrain00006311 | |||||||||
| WBStrain00051497 | |||||||||
| WBStrain00051632 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Structured_description | Concise_description | lin-4 encodes a small non-coding temporal RNA (stRNA); lin-4 activity is required for regulating the timing of fate specification in neuronal and hypodermal lineages during postembryonic development; in the hypodermis, lin-4 represses translation of the lin-14 and lin-28 mRNAs, and in the ventral nerve cord, lin-4 regulates the expression of hbl-1 mRNA; in vitro, lin-4 binds the lin-14 mRNA 3' UTR to form an RNA duplex; lin-4 expression is temporally regulated, beginning at the end of the L1 larval stage and increasing to highest levels in adult animals; lin-4 is conserved in mammals and Drosophila, where it is known as miR-125. | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00002609 | |||||||||
| WBPaper00002728 | |||||||||
| WBPaper00003583 | |||||||||
| WBPaper00005159 | |||||||||
| WBPaper00005825 | |||||||||
| WBPaper00005909 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 18 Aug 2008 00:00:00 | ||||||||
| Automated_description | Enables mRNA 3'-UTR binding activity. Involved in several processes, including egg-laying behavior; mating; and negative regulation of gene expression. Part of polysome. Expressed in several structures, including P5.p hermaphrodite; P7.p hermaphrodite; gonad; neurons; and ventral nerve cord. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_transcript | F59G1.6 | |||||||
| F59G1.6a | |||||||||
| F59G1.6b | |||||||||
| Associated_feature | WBsf034324 | ||||||||
| WBsf977968 | Paper_evidence | WBPaper00044681 | |||||||
| WBsf979102 | |||||||||
| Gene_product_binds | WBsf019183 | ||||||||
| WBsf019184 | |||||||||
| WBsf132693 | |||||||||
| Experimental_info | Expr_pattern (14) | ||||||||
| Drives_construct | WBCnstr00000927 | ||||||||
| WBCnstr00000928 | |||||||||
| WBCnstr00004691 | |||||||||
| WBCnstr00005149 | |||||||||
| WBCnstr00005518 | |||||||||
| WBCnstr00007615 | |||||||||
| WBCnstr00015029 | |||||||||
| WBCnstr00016040 | |||||||||
| WBCnstr00019505 | |||||||||
| WBCnstr00020503 | |||||||||
| Construct_product | WBCnstr00000927 | ||||||||
| WBCnstr00000928 | |||||||||
| WBCnstr00007618 | |||||||||
| WBCnstr00007620 | |||||||||
| WBCnstr00007623 | |||||||||
| WBCnstr00016930 | |||||||||
| Regulate_expr_cluster | WBPaper00026952:class_A | ||||||||
| WBPaper00026952:class_B | |||||||||
| WBPaper00026952:class_C | |||||||||
| WBPaper00026952:class_D | |||||||||
| WBPaper00026952:class_E | |||||||||
| WBPaper00026952:class_F | |||||||||
| WBPaper00026952:class_G | |||||||||
| WBPaper00026952:class_H | |||||||||
| Expression_cluster (16) | |||||||||
| Interaction (158) | |||||||||
| WBProcess | WBbiopr:00000031 | ||||||||
| WBbiopr:00000057 | |||||||||
| WBbiopr:00000081 | |||||||||
| WBbiopr:00000083 | |||||||||
| Map_info | Map | II | Position | -0.85522 | Error | 0.001406 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | arDp2 | |||||||
| Positive_clone | C02B6 | ||||||||
| F59G1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Negative | Outside_rearr | ccDf5 | |||||||
| Mapping_data | 2_point | 40 | |||||||
| 777 | |||||||||
| 4220 | |||||||||
| Multi_point (15) | |||||||||
| Pos_neg_data | 3708 | ||||||||
| 4223 | |||||||||
| 4224 | |||||||||
| 5921 | |||||||||
| 9121 | |||||||||
| 10365 | |||||||||
| Landmark_gene | |||||||||
| Reference (400) | |||||||||
| Remark | Rfam accession number: MI0000002 | ||||||||
| Method | Gene |
