WormBase Tree Display for Gene: WBGene00002978
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| WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lev-11 | Person_evidence | WBPerson368 | |||||
| Sequence_name | Y105E8B.1 | ||||||||
| Molecular_name | Y105E8B.1a | ||||||||
| Y105E8B.1a.1 | |||||||||
| CE28782 | |||||||||
| Y105E8B.1b | |||||||||
| CE36223 | |||||||||
| Y105E8B.1c | |||||||||
| CE29059 | |||||||||
| Y105E8B.1d | |||||||||
| CE29060 | |||||||||
| Y105E8B.1e | |||||||||
| CE31733 | |||||||||
| Y105E8B.1f | |||||||||
| CE36224 | |||||||||
| Y105E8B.1g | |||||||||
| CE48010 | |||||||||
| Y105E8B.1i | |||||||||
| CE47868 | |||||||||
| Y105E8B.1j | |||||||||
| CE48059 | |||||||||
| Y105E8B.1k | |||||||||
| CE50243 | |||||||||
| Y105E8B.1l | |||||||||
| CE28784 | |||||||||
| Y105E8B.1m | |||||||||
| CE50134 | |||||||||
| Y105E8B.1n | |||||||||
| CE50275 | |||||||||
| Y105E8B.1o | |||||||||
| CE50292 | |||||||||
| Y105E8B.1p | |||||||||
| CE50234 | |||||||||
| Y105E8B.1q | |||||||||
| CE50171 | |||||||||
| Y105E8B.1r | |||||||||
| CE50169 | |||||||||
| Y105E8B.1s | |||||||||
| CE50164 | |||||||||
| Y105E8B.1t | |||||||||
| CE51960 | |||||||||
| Y105E8B.1b.1 | |||||||||
| Y105E8B.1c.1 | |||||||||
| Y105E8B.1d.1 | |||||||||
| Y105E8B.1e.1 | |||||||||
| Y105E8B.1e.2 | |||||||||
| Y105E8B.1f.1 | |||||||||
| Y105E8B.1g.1 | |||||||||
| Y105E8B.1i.1 | |||||||||
| Y105E8B.1j.1 | |||||||||
| Y105E8B.1k.1 | |||||||||
| Y105E8B.1l.1 | |||||||||
| Y105E8B.1m.1 | |||||||||
| Y105E8B.1n.1 | |||||||||
| Y105E8B.1o.1 | |||||||||
| Y105E8B.1p.1 | |||||||||
| Y105E8B.1q.1 | |||||||||
| Y105E8B.1r.1 | |||||||||
| Y105E8B.1s.1 | |||||||||
| Y105E8B.1t.1 | |||||||||
| Other_name | tmy-1 | ||||||||
| Y105E8B.c | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CeTM | Paper_evidence | WBPaper00005168 | |||||||
| WBPaper00032338 | |||||||||
| CELE_Y105E8B.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | lev-11 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lev | ||||||||
| Reference_allele | WBVar00275207 | ||||||||
| Allele (206) | |||||||||
| Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | ||||||||
| See also e1724 | |||||||||
| [Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | |||||||||
| [C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | |||||||||
| [C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | |||||||||
| Strain | WBStrain00002959 | ||||||||
| WBStrain00033515 | |||||||||
| WBStrain00033518 | |||||||||
| WBStrain00033524 | |||||||||
| WBStrain00040917 | |||||||||
| WBStrain00040918 | |||||||||
| WBStrain00004923 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (47) | |||||||||
| Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | |||||
| WBPaper00004944 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111597 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||
| DOID:0110926 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:0110309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:0110457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:3969 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:0110932 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12011) | ||||||
| DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12010) | ||||||
| DOID:0080102 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12012) | ||||||
| DOID:2218 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12013) | ||||||
| Molecular_info | Corresponding_CDS (19) | ||||||||
| Corresponding_CDS_history | Y105E8B.1b:wp62 | ||||||||
| Y105E8B.1b:wp114 | |||||||||
| Y105E8B.1c:wp62 | |||||||||
| Corresponding_transcript (20) | |||||||||
| Other_sequence (913) | |||||||||
| Associated_feature (35) | |||||||||
| Experimental_info | RNAi_result (31) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (12) | |||||||||
| Construct_product | WBCnstr00010369 | ||||||||
| WBCnstr00012505 | |||||||||
| WBCnstr00016244 | |||||||||
| WBCnstr00041176 | |||||||||
| Antibody | WBAntibody00000099 | ||||||||
| WBAntibody00000422 | |||||||||
| WBAntibody00000423 | |||||||||
| WBAntibody00000472 | |||||||||
| Microarray_results (61) | |||||||||
| Expression_cluster (304) | |||||||||
| Interaction (175) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | 2_point | 209 | |||||||
| 213 | |||||||||
| 214 | |||||||||
| 327 | |||||||||
| 5106 | |||||||||
| 6076 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data | 4782 | ||||||||
| 4797 | |||||||||
| 4812 | |||||||||
| 4827 | |||||||||
| 4842 | |||||||||
| 4857 | |||||||||
| 4872 | |||||||||
| 4887 | |||||||||
| 4902 | |||||||||
| 4917 | |||||||||
| 4932 | |||||||||
| 4947 | |||||||||
| 4962 | |||||||||
| Reference (90) | |||||||||
| Remark | Data extracted from Williams & Waterston 1994 | ||||||||
| The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||||
| Method | Gene |
