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WormBase Tree Display for Gene: WBGene00002978

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Name Class

WBGene00002978SMapS_parentSequenceY105E8B
IdentityVersion1
NameCGC_namelev-11Person_evidenceWBPerson368
Sequence_nameY105E8B.1
Molecular_name (58)
Other_nametmy-1
Y105E8B.cCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CeTMPaper_evidenceWBPaper00005168
WBPaper00032338
CELE_Y105E8B.1Accession_evidenceNDBBX284601
Public_namelev-11
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlev
Reference_alleleWBVar00275207
Allele (206)
Legacy_informationx12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal).
See also e1724
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping.
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS.
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK]
StrainWBStrain00002959
WBStrain00033515
WBStrain00033518
WBStrain00033524
WBStrain00040917
WBStrain00040918
WBStrain00004923
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (47)
Structured_descriptionConcise_descriptionlev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line.Paper_evidenceWBPaper00002748
WBPaper00004944
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111597Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0110926Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110309Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0110457Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:3969Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:0110932Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12011)
DOID:0080326Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12010)
DOID:0080102Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12012)
DOID:2218Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12013)
Molecular_infoCorresponding_CDS (19)
Corresponding_CDS_historyY105E8B.1b:wp62
Y105E8B.1b:wp114
Y105E8B.1c:wp62
Corresponding_transcript (20)
Other_sequenceD38540
D38541
D38542
PT02847
WBC01402_1
FG971696.1
HBC10599_1
FF680067.1
EY462788.1
EX910915.1
EY464315.1
SS01171
FG980540.1
HSC00510_1
FC544713.1
FK806177.1
FG975177.1
FG974479.1
FG974053.1
HG08144
FF680643.1
FK801456.1
FF681115.1
FG973046.1
BG577835.1
MI06813
FG977019.1
GR367773.1
FG978816.1
EY462569.1
FG977599.1
FG980587.1
FG973525.1
FG972515.1
FG972635.1
FG972427.1
ES566948.1
FG980607.1
FG974913.1
FG970774.1
Dviv_isotig01174
AI096017.1
BUC01311_1
FG979151.1
EX500773.1
GW412705.1
FG971480.1
FG976200.1
FG977894.1
FG973238.1
EX915478.1
NAC01588_1
FG976995.1
CBC09683_1
EX561457.1
FF679743.1
AI313770.1
ES414274.1
FF681439.1
FF678895.1
FK801943.1
FG979844.1
ASC04697_1
FG978672.1
FG979289.1
FG971346.1
FG971321.1
FF680605.1
PT01044
HG08923
ES742550.1
FG970711.1
FG975750.1
FG975680.1
FG978382.1
BE760999.1
BXC00949_1
EX546307.1
FG978147.1
CB038277.1
PPC02116_1
EX546028.1
FG975349.1
ES563431.1
BE217707.1
HBC01120_1
FG974472.1
EX911110.1
FG972812.1
EX537456.1
FG972526.1
DA00160
TM01151
FG971190.1
FG978217.1
XI01191
JI214527.1
FG972859.1
MJC00351_1
FJ655903.1
FG973412.1
GO249034.1
FG973583.1
GPC00554_1
Acan_isotig00103
CSC00763_1
FG972459.1
FF681016.1
CB038181.1
BE202306.1
FG979733.1
FG980081.1
TSC01040_1
FG975959.1
FF680101.1
FG973005.1
HG08495
FG974185.1
HBC14270_1
TDC00858_1
FG971446.1
FF679857.1
Y19221.1
FG973062.1
FD516018.1
FF679859.1
FG980434.1
ES413695.1
FG973744.1
FG977248.1
FG971972.1
FF681575.1
PVC00840_1
GRC00453_1
CRC03050_1
FG977386.1
FG973978.1
MI00997
FC810253.1
FG978780.1
AJ224966.1
ES411437.1
MI06036
DAC00081_1
DA04805
AI096121.1
FG972687.1
FG975120.1
EX013954.1
FG976189.1
FG972108.1
CB037762.1
FG976782.1
FG971560.1
ES410384.1
Acan_isotig00108
FG978916.1
JI471282.1
FG976960.1
FG975087.1
OVC00801_1
HGC08828_1
FG978107.1
BE899665.1
FG978658.1
GW412508.1
FG980695.1
EX012406.1
FG980568.1
FG980624.1
ES564406.1
CBC00908_3
FG977727.1
MH07965
FF679563.1
FF681025.1
FG971298.1
FG974574.1
MC05002
FG979666.1
Dviv_isotig01175
FG974702.1
FG977012.1
MCC02354_1
FF679558.1
HBC07157_1
GW408961.1
AM743952.1
TS01635
FG973556.1
FF680333.1
FG974088.1
Tcol_isotig02429
EY465225.1
FG973872.1
FG970861.1
FF681493.1
FG974322.1
FG978763.1
FG976521.1
FG980846.1
FG980240.1
Hbac_isotig00014
PEC00078_1
FG976056.1
FG975193.1
FG971876.1
FG974969.1
BF169293.1
EY465711.1
EU131541.1
MIC00674_1
EY469585.1
FG980279.1
FG977793.1
FG979751.1
GR11973
MHC06991_1
FF680128.1
FG980243.1
AI066889.1
FG971409.1
FG971769.1
FG973798.1
FG977863.1
ES408916.1
FG973863.1
FG980662.1
RSC03219_1
FF680774.1
HBC00440_1
DA02385
EY471104.1
FG971760.1
FG972227.1
AF546757.1
EX538340.1
JI462505.1
EX007012.1
FF680149.1
FG970735.1
FG975687.1
FG971186.1
FG977274.1
GW406139.1
FG974481.1
FG971225.1
FG974575.1
XIC02558_1
FG980055.1
EY470403.1
FG971085.1
EX008273.1
FG976252.1
JI479289.1
MC00914
FG978922.1
FG980029.1
PT00467
CJC15149_1
FG978353.1
EX014056.1
AS14007
FG981148.1
CGC01120_1
JI169886.1
FG977420.1
FK807357.1
FG974309.1
FC548317.1
FG979915.1
FG972644.1
FG973912.1
HBC20594_1
HBC00200_1
FG979858.1
FG978811.1
FG973721.1
SS00615
FF680920.1
Tcir_isotig10267
FF679757.1
PSC00361_1
FG978956.1
AF000607.1
FG971032.1
TDC01038_1
FG979624.1
FG975226.1
FG976827.1
ACC19562_1
GO249744.1
EX564316.1
BE420513.1
FG975852.1
FG976916.1
CSC00639_1
GRC02622_1
Oden_isotig26493
JI477797.1
FG972714.1
EX828262.1
MJ04971
CK850057.1
ES411375.1
FG975981.1
FG975827.1
HBC08828_1
FG971122.1
FG976086.1
BF400331.1
MI03147
MH01212
ACC11709_1
FG972550.1
AF419300.1
FF679951.1
PSC00742
JI216186.1
EL889973.1
DAC01340_1
EX543079.1
FG973338.1
FF681322.1
ES672745.1
FG972785.1
FG975390.1
EY471483.1
ES739281.1
BE225562.1
FG977147.1
FG977293.1
EY473360.1
FC815637.1
HBC00148_1
EX549175.1
FG980795.1
BXC00048_1
HG03504
FG972390.1
Tcol_isotig02431
FG972472.1
FG973799.1
Dviv_isotig01178
EX536520.1
FG980184.1
EX915220.1
FG978571.1
FG981072.1
FG977687.1
FG980507.1
Oden_isotig07126
FG980181.1
CRC00045_1
FG978357.1
FF679452.1
FG971524.1
FG976844.1
FC555094.1
FG976737.1
FG972707.1
FG979191.1
EX910347.1
BUC00143_1
AI438750.1
FG979591.1
FG980179.1
FG970691.1
JI180367.1
FD515391.1
FG975488.1
BMC04766_1
FF680180.1
FG974241.1
HBC04876_1
FG979320.1
FG978871.1
JI482010.1
PTC00333_1
EX535409.1
BE132585.1
FG973149.1
FG972654.1
MC04602
AA907973.1
FK805087.1
FG976019.1
FG975550.1
BMC00669_1
AA294458.1
Hbac_isotig00013
CB038111.1
FG975985.1
FG975616.1
GR463911.1
FG971354.1
FF680107.1
EY461484.1
FG980808.1
ES566442.1
MIC02022_1
FG973099.1
ES412840.1
AA610987.1
GO250115.1
FG973143.1
FG976650.1
FG974504.1
CBC00908_2
ASC26141_1
OOC01731_1
FG971805.1
EX911490.1
EX555660.1
FG972581.1
FG978928.1
Dviv_isotig01176
FG977596.1
FF680657.1
FG979673.1
FG973056.1
FG980818.1
TMC00234_1
FG977195.1
EY471058.1
EX013101.1
BXC04790_1
EF533995.1
SSC00411_1
Hbac_isotig06030
HBC05799_1
TSC00987_1
FG975040.1
FG975567.1
FG976701.1
FG977785.1
EX912357.1
ASC13815_1
FG977926.1
FG976290.1
BMC07313_1
CB037093.1
FG979115.1
FG973242.1
HGC05859_1
AI130353.1
FG974865.1
FG975500.1
FF681062.1
HBC02783_1
FG973209.1
JI459475.1
SR00241
MIC05172_1
FG975451.1
AA080831.1
BE202325.1
FF681524.1
EX566113.1
FG972479.1
CGC00422_1
FG970745.1
AS01772
FG974605.1
FG972286.1
JI473797.1
HBC23162_1
FG971247.1
CV200563.1
FG973973.1
FG970805.1
J04669.1
CBC01773_1
EY463267.1
Acan_isotig00107
JI475878.1
FG975871.1
FG974960.1
ACC06680_1
FG974155.1
CR02766
FG971011.1
CBC09079_1
FG979298.1
OVC00551_1
DA02384
FG979596.1
TM01513
BG734382.1
FF681219.1
FG974208.1
FG973883.1
HC01930
PP00432
HC00472
FG973013.1
FG972829.1
FG971869.1
EF552222.1
FG976245.1
CJC03605_1
HCC06886_1
FG973253.1
EE724202.1
FG980917.1
BG734443.1
HBC21510_1
FG977467.1
FG972524.1
FG974661.1
EX828585.1
FG977171.1
FG978993.1
FG980049.1
FG973458.1
FG981107.1
FG980628.1
FF680468.1
EY459842.1
FG972011.1
FG978569.1
FG972517.1
FG978026.1
HBC16290_1
AW499467.1
GW406922.1
FG972942.1
MH02432
CR02934
FG979630.1
FG978271.1
FG970813.1
CR00047
Oden_isotig07127
EL890460.1
GO250215.1
EY471775.1
FF681718.1
GO250230.1
FG975278.1
FG979113.1
FD516876.1
TMC00737_1
FF681592.1
FG978577.1
FG971262.1
DA05096
FF681098.1
FG973256.1
MI03894
TMC01189_1
FG979177.1
FG971632.1
FG979981.1
DAC00935_1
FG979559.1
FG976465.1
FG975530.1
FG974284.1
FG978121.1
FG976860.1
EY465083.1
TDC02420_1
DA03929
FG980462.1
FG978511.1
Acan_isotig00105
PP02222
FF678648.1
JI166799.1
FG979201.1
FF680799.1
FG974476.1
FG979042.1
FG977953.1
FG975342.1
FG973434.1
HBC14084_1
EX500481.1
JI176757.1
AA934313.1
FG979636.1
FG976144.1
HBC22362_1
FK800093.1
HBC06268_1
FF681535.1
TS00522
FG971989.1
JI216266.1
EY467828.1
BU087084.1
WBC00060_1
L41633.1
FG975559.1
GU130141.1
XI00199
EY472083.1
FG976366.1
FG978585.1
JI175599.1
HBC00135_2
FG976674.1
Oden_isotig07124
FF680930.1
BUC00877_1
EL888158.1
ACC07259_1
BE760992.1
FG978056.1
FG979373.1
FG974754.1
FG978027.1
AI057962.1
FG978696.1
EX539927.1
SSC02755_1
FG971638.1
FC548153.1
AA610978.1
FG976627.1
EY473604.1
FG979628.1
FF680790.1
FG972735.1
EY467529.1
Tcol_isotig02434
FG979058.1
MI06734
FG975591.1
Dviv_isotig01172
OOC02713_1
EU573931.1
FD515516.1
DA03801
Oden_isotig07123
ES742882.1
FG978316.1
FG975230.1
FG979497.1
FG972793.1
FG972776.1
MHC02994_1
FG972236.1
FG972012.1
GR13437
FG974296.1
FG975590.1
ES414268.1
FC549146.1
CB037671.1
FG980171.1
FG978846.1
FG971778.1
FF681673.1
FG977178.1
GO249096.1
FG977629.1
BE420440.1
FG977650.1
FG978102.1
Tcol_isotig02430
FG974772.1
FG980866.1
FG974104.1
FG971338.1
HBC01834_1
FF681717.1
FG582027.1
ES561585.1
FG972042.1
FG981003.1
FG978995.1
FG977533.1
SSC03019_1
JI171812.1
FE905635.1
HGC01255_1
FG976118.1
RS10069
EX548909.1
CR11077
FG978371.1
HBC00135_1
ES566381.1
FF681711.1
FG974933.1
FG971297.1
FG980101.1
FG977284.1
AI061480.1
Acan_isotig00106
EY468352.1
FG974465.1
FF681614.1
JI471104.1
HCC01686_1
FR694973.1
FG976380.1
FG972215.1
FF680427.1
DA02837
JI248792.1
GU290222.1
FG973538.1
FG978228.1
FG976783.1
FG976239.1
FD515099.1
Oden_isotig07125
JI182617.1
CJC02017_1
FG971135.1
FG977546.1
JI212333.1
FG977630.1
GR18184
FF680789.1
GRC04604_1
PP02036
SRC01749_1
SSC03019_2
FG972541.1
FG978801.1
FG976867.1
FG971907.1
JI181525.1
FG588673.1
FG974764.1
DA00279
Tcol_isotig02433
FG976850.1
FF680781.1
JI218114.1
FG978122.1
FG973714.1
EY469159.1
PE00234
ACC10077_1
FG973214.1
FG970982.1
AI096313.1
HBC03189_1
ES743930.1
AF453521.1
GW407110.1
JI182569.1
FG976057.1
EX502286.1
Name_isotig02954
FF679797.1
FG980762.1
EL889331.1
FG975002.1
GO249947.1
FG974940.1
FG976326.1
FF681549.1
AI057983.1
HC05364
FG979153.1
FF680528.1
FG976271.1
FG978170.1
OVC00543_1
AI130478.1
FG978103.1
HS00425
EY465207.1
Oden_isotig07122
FG979171.1
FG972177.1
CRC06400_1
ES570822.1
XIC01121_1
HBC06775_1
FG974665.1
FK805410.1
JI468426.1
FG352177.1
FF679482.1
CK726176.1
FG979501.1
HBC20549_1
EY465602.1
Tcol_isotig02432
FG980853.1
HBC00453_1
FG978093.1
Dviv_isotig01170
FC539225.1
FD514212.1
FG979500.1
CBC09815_1
GP00317
FG977774.1
FG972220.1
GR977403.1
HBC08718_1
AS08772
EL888080.1
ASC21904_1
FG980717.1
Dviv_isotig01171
FG976182.1
FG979754.1
FG970998.1
FG976361.1
EX910371.1
CB038507.1
EX014107.1
EL887994.1
ES742088.1
FG975414.1
HBC16331_1
FG978219.1
PPC08253_1
JI170846.1
FG975058.1
OVC06818_1
FG977524.1
FG980460.1
Dviv_isotig01173
GW411737.1
GW410461.1
FF680737.1
FG980773.1
PPC02204_1
FG974405.1
DA05981
FG975082.1
FG971888.1
FG979066.1
HBC09730_1
CRC09197_1
FK808061.1
ACC39847_1
GR18185
FG980842.1
MI02952
FF680561.1
EY463092.1
FF681173.1
FK804734.1
FG977592.1
FG979694.1
FF681188.1
FG973048.1
CRC05630_1
FG980577.1
FG973628.1
HBC22841_1
SC01431
FG971244.1
TSC03471_1
HCC00209_1
FG973108.1
XIC04778_1
FC555333.1
JI176390.1
FG975898.1
FG975743.1
CV199971.1
FG972869.1
AI374038.1
CB038049.1
FG979799.1
FG979924.1
OVC03937_1
XI03144
PE00209
GO249488.1
FG979774.1
FG979768.1
FG977700.1
FF681124.1
SS01430
AA666429.1
GR13171
EX536623.1
FG971349.1
FG971975.1
Dviv_isotig01177
FG974110.1
FG977820.1
FG972752.1
Tcol_isotig02428
HG09260
EX558461.1
FG977379.1
PPC01383_1
JO468396.1
FG975460.1
FG580868.1
FG970731.1
FG979169.1
FG977197.1
FG981152.1
TS01052
PTC02741_1
FF681296.1
FG979202.1
FF680551.1
FG979801.1
FG978804.1
FG980885.1
MI02523
Acan_isotig00104
FG975724.1
DA03797
AI511542.1
FF679809.1
FG977660.1
Associated_feature (35)
Experimental_infoRNAi_result (31)
Expr_pattern (15)
Drives_construct (12)
Construct_productWBCnstr00010369
WBCnstr00012505
WBCnstr00016244
WBCnstr00041176
AntibodyWBAntibody00000099
WBAntibody00000422
WBAntibody00000423
WBAntibody00000472
Microarray_results (61)
Expression_cluster (304)
Interaction (175)
WBProcessWBbiopr:00000006
Map_infoMapIPosition25.8125Error0.018971
Well_ordered
PositivePositive_cloneY105E8BInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_data2_point209
213
214
327
5106
6076
Multi_point (11)
Pos_neg_data (13)
Reference (90)
RemarkData extracted from Williams & Waterston 1994
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02
MethodGene