WormBase Tree Display for Gene: WBGene00002978

WBGene00002978 SMap: S_parent: Sequence: Y105E8B
  Identity: Version: 1
    Name: CGC_name: lev-11 Person_evidence: WBPerson368
      Sequence_name: Y105E8B.1
      Molecular_name (58)
      Other_name: tmy-1
        Y105E8B.c Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CeTM Paper_evidence: WBPaper00005168
            WBPaper00032338
        CELE_Y105E8B.1 Accession_evidence: NDB BX284601
      Public_name: lev-11
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lev
    Reference_allele: WBVar00275207
    Allele (206)
    Legacy_information: x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal).
      See also e1724
      [Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping.
      [C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS.
      [C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK]
    Strain: WBStrain00002959
      WBStrain00033515
      WBStrain00033518
      WBStrain00033524
      WBStrain00040917
      WBStrain00040918
      WBStrain00004923
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (47)
    Structured_description: Concise_description: lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. Paper_evidence: WBPaper00002748
            WBPaper00004944
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111597 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12011)
      DOID:0110926 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12012)
      DOID:0110309 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12010)
      DOID:0110457 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12010)
      DOID:3969 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12012)
      DOID:0110932 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12011)
      DOID:0080326 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12010)
      DOID:0080102 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12012)
      DOID:2218 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:12013)
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: Y105E8B.1b:wp62
      Y105E8B.1b:wp114
      Y105E8B.1c:wp62
    Corresponding_transcript (20)
    Other_sequence (913)
    Associated_feature (35)
  Experimental_info: RNAi_result (31)
    Expr_pattern (15)
    Drives_construct (12)
    Construct_product: WBCnstr00010369
      WBCnstr00012505
      WBCnstr00016244
      WBCnstr00041176
    Antibody: WBAntibody00000099
      WBAntibody00000422
      WBAntibody00000423
      WBAntibody00000472
    Microarray_results (61)
    Expression_cluster (304)
    Interaction: WBInteraction000005020
      WBInteraction000005437
      WBInteraction000009172
      WBInteraction000009173
      WBInteraction000009174
      WBInteraction000009175
      WBInteraction000028443
      WBInteraction000028723
      WBInteraction000028867
      WBInteraction000028893
      WBInteraction000029433
      WBInteraction000029535
      WBInteraction000032613
      WBInteraction000032692
      WBInteraction000032693
      WBInteraction000033012
      WBInteraction000033134
      WBInteraction000033271
      WBInteraction000033713
      WBInteraction000033745
      WBInteraction000033780
      WBInteraction000034131
      WBInteraction000034816
      WBInteraction000035116
      WBInteraction000035228
      WBInteraction000035354
      WBInteraction000035443
      WBInteraction000035724
      WBInteraction000035960
      WBInteraction000036994
      WBInteraction000037226
      WBInteraction000037943
      WBInteraction000039534
      WBInteraction000039972
      WBInteraction000039988
      WBInteraction000040281
      WBInteraction000041399
      WBInteraction000041503
      WBInteraction000041828
      WBInteraction000041839
      WBInteraction000042174
      WBInteraction000042175
      WBInteraction000043350
      WBInteraction000043755
      WBInteraction000044390
      WBInteraction000044391
      WBInteraction000044392
      WBInteraction000045241
      WBInteraction000045495
      WBInteraction000046697
      WBInteraction000046872
      WBInteraction000047482
      WBInteraction000047549
      WBInteraction000047583
      WBInteraction000047970
      WBInteraction000048479
      WBInteraction000048704
      WBInteraction000049136
      WBInteraction000049597
      WBInteraction000052055
      WBInteraction000052056
      WBInteraction000052057
      WBInteraction000052373
      WBInteraction000052374
      WBInteraction000052375
      WBInteraction000052376
      WBInteraction000052377
      WBInteraction000114225
      WBInteraction000114226
      WBInteraction000114227
      WBInteraction000114228
      WBInteraction000126651
      WBInteraction000137989
      WBInteraction000159735
      WBInteraction000159737
      WBInteraction000159739
      WBInteraction000159741
      WBInteraction000169930
      WBInteraction000169979
      WBInteraction000174016
      WBInteraction000361629
      WBInteraction000361630
      WBInteraction000417014
      WBInteraction000500377
      WBInteraction000500378
      WBInteraction000503624
      WBInteraction000503625
      WBInteraction000518956
      WBInteraction000519855
      WBInteraction000521645
      WBInteraction000521646
      WBInteraction000521647
      WBInteraction000522895
      WBInteraction000522901
      WBInteraction000522926
      WBInteraction000522986
      WBInteraction000523012
      WBInteraction000523083
      WBInteraction000523097
      WBInteraction000523161
      WBInteraction000523179
      WBInteraction000523229
      WBInteraction000523234
      WBInteraction000523248
      WBInteraction000523278
      WBInteraction000523318
      WBInteraction000523324
      WBInteraction000523341
      WBInteraction000523347
      WBInteraction000523356
      WBInteraction000523444
      WBInteraction000523463
      WBInteraction000523496
      WBInteraction000523499
      WBInteraction000523501
      WBInteraction000523512
      WBInteraction000523550
      WBInteraction000523576
      WBInteraction000539665
      WBInteraction000541749
      WBInteraction000541816
      WBInteraction000542700
      WBInteraction000543627
      WBInteraction000543668
      WBInteraction000543677
      WBInteraction000543685
      WBInteraction000543708
      WBInteraction000543738
      WBInteraction000543753
      WBInteraction000543755
      WBInteraction000543765
      WBInteraction000543797
      WBInteraction000543831
      WBInteraction000543846
      WBInteraction000543894
      WBInteraction000543942
      WBInteraction000543954
      WBInteraction000543972
      WBInteraction000543986
      WBInteraction000544000
      WBInteraction000544029
      WBInteraction000546172
      WBInteraction000548284
      WBInteraction000550260
      WBInteraction000551447
      WBInteraction000552795
      WBInteraction000554032
      WBInteraction000554936
      WBInteraction000554937
      WBInteraction000554938
      WBInteraction000554939
      WBInteraction000555108
      WBInteraction000559553
      WBInteraction000561499
      WBInteraction000561737
      WBInteraction000562254
      WBInteraction000562348
      WBInteraction000562503
      WBInteraction000562698
      WBInteraction000564022
      WBInteraction000564581
      WBInteraction000566227
      WBInteraction000566506
      WBInteraction000568091
      WBInteraction000569281
      WBInteraction000569771
      WBInteraction000570959
      WBInteraction000572319
      WBInteraction000572548
      WBInteraction000572770
      WBInteraction000580134
      WBInteraction000582833
      WBInteraction000584692
      WBInteraction000585949
      WBInteraction000586409
    WBProcess: WBbiopr:00000006
  Map_info: Map: I Position: 25.8125 Error: 0.018971
    Well_ordered
    Positive: Positive_clone: Y105E8B Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 209
        213
        214
        327
        5106
        6076
      Multi_point (11)
      Pos_neg_data (13)
  Reference (90)
  Remark: Data extracted from Williams & Waterston 1994
    The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02
  Method: Gene