WormBase Tree Display for Gene: WBGene00002974
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WBGene00002974 | SMap | S_parent | Sequence | F58D2 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lev-1 | Person_evidence | WBPerson368 | |||||
Sequence_name | F09E8.7 | ||||||||
Molecular_name | F09E8.7a | ||||||||
F09E8.7a.1 | |||||||||
CE24888 | |||||||||
F09E8.7b | |||||||||
CE43918 | |||||||||
F09E8.7b.1 | |||||||||
Other_name | acr-1 | ||||||||
tmr-1 | |||||||||
CELE_F09E8.7 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | lev-1 | ||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lev | ||||||||
Reference_allele | WBVar00143038 | ||||||||
Allele (119) | |||||||||
Legacy_information | e211 (pka tmr-1) : almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. NA > 10 (x22 etc.). Also two rare semidominant alleles with uncoordinated phenotype x21 : (uncoordinated Egl-c ME3) x63. | ||||||||
See also e211, e289 | |||||||||
[C.elegansII] e211 : (pka tmr-1) almost normal movement in absence of drug uncoordinated but not hypercontracted in 1 mM levamisole. ES2. ME3. OA>10: x22, e289, x577 etc. Also two rare semidominant alleles with uncoordinated phenotype, x21 (uncoordinated Egl-c, ME3), x63. Cloned: corresponds to acr-1, encoding subunit of nicotinic acetylcholine receptor. [Lewis et al. 1980, 1987; ZZ; MQ] | |||||||||
Strain | WBStrain00003893 | ||||||||
WBStrain00030691 | |||||||||
WBStrain00033031 | |||||||||
WBStrain00040924 | |||||||||
WBStrain00000741 | |||||||||
WBStrain00004129 | |||||||||
WBStrain00004573 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (37) | |||||||||
Ortholog (46) | |||||||||
Paralog (100) | |||||||||
Structured_description | Concise_description | lev-1 encodes a non-alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, regulation of egg-laying behavior, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3; a LEV-1::GFP fusion protein is expressed in all body wall muscle cells and a subset of ventral cord motor neurons. | Paper_evidence | WBPaper00000031 | |||||
WBPaper00004660 | |||||||||
WBPaper00005223 | |||||||||
WBPaper00024530 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 20 Jun 2008 00:00:00 | ||||||||
Automated_description | Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:3905 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||
DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:3083 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:0110663 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||||
DOID:1324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:0050742 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1957) | ||||||
DOID:0110662 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1955) | ||||||
Molecular_info | Corresponding_CDS | F09E8.7a | |||||||
F09E8.7b | |||||||||
Corresponding_transcript | F09E8.7a.1 | ||||||||
F09E8.7b.1 | |||||||||
Other_sequence (14) | |||||||||
Associated_feature | WBsf652327 | ||||||||
WBsf668451 | |||||||||
WBsf668452 | |||||||||
WBsf668453 | |||||||||
WBsf668454 | |||||||||
WBsf998352 | |||||||||
WBsf998353 | |||||||||
WBsf1018500 | |||||||||
WBsf231093 | |||||||||
Experimental_info | RNAi_result | WBRNAi00102763 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00012987 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00001574 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066400 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00044139 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066521 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr3395 | ||||||||
Expr3708 | |||||||||
Expr3709 | |||||||||
Expr4346 | |||||||||
Expr1027358 | |||||||||
Expr1031374 | |||||||||
Expr1148107 | |||||||||
Expr2013085 | |||||||||
Expr2031317 | |||||||||
Drives_construct (12) | |||||||||
Construct_product (14) | |||||||||
Microarray_results (19) | |||||||||
Expression_cluster (125) | |||||||||
Interaction (25) | |||||||||
Map_info | Map | IV | Position | 8.43149 | Error | 0.004865 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | nDf27 | |||||||
nDf28 | |||||||||
sDf21 | |||||||||
Positive_clone | F09E8 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
JF#WA10 | |||||||||
Mapping_data | 2_point | 228 | |||||||
229 | |||||||||
347 | |||||||||
2726 | |||||||||
4660 | |||||||||
4661 | |||||||||
4666 | |||||||||
Multi_point (19) | |||||||||
Pos_neg_data (11) | |||||||||
Reference | WBPaper00000031 | ||||||||
WBPaper00000464 | |||||||||
WBPaper00000484 | |||||||||
WBPaper00000538 | |||||||||
WBPaper00000608 | |||||||||
WBPaper00000622 | |||||||||
WBPaper00000950 | |||||||||
WBPaper00000998 | |||||||||
WBPaper00001296 | |||||||||
WBPaper00001461 | |||||||||
WBPaper00001860 | |||||||||
WBPaper00002024 | |||||||||
WBPaper00002297 | |||||||||
WBPaper00002641 | |||||||||
WBPaper00002748 | |||||||||
WBPaper00002860 | |||||||||
WBPaper00003024 | |||||||||
WBPaper00003080 | |||||||||
WBPaper00003300 | |||||||||
WBPaper00003425 | |||||||||
WBPaper00003483 | |||||||||
WBPaper00003655 | |||||||||
WBPaper00004117 | |||||||||
WBPaper00004257 | |||||||||
WBPaper00004451 | |||||||||
WBPaper00004660 | |||||||||
WBPaper00005223 | |||||||||
WBPaper00005594 | |||||||||
WBPaper00006102 | |||||||||
WBPaper00006324 | |||||||||
WBPaper00011815 | |||||||||
WBPaper00011839 | |||||||||
WBPaper00013670 | |||||||||
WBPaper00013819 | |||||||||
WBPaper00014118 | |||||||||
WBPaper00014376 | |||||||||
WBPaper00014635 | |||||||||
WBPaper00014738 | |||||||||
WBPaper00015032 | |||||||||
WBPaper00015033 | |||||||||
WBPaper00015302 | |||||||||
WBPaper00015303 | |||||||||
WBPaper00015376 | |||||||||
WBPaper00015580 | |||||||||
WBPaper00015839 | |||||||||
WBPaper00016088 | |||||||||
WBPaper00016188 | |||||||||
WBPaper00016273 | |||||||||
WBPaper00016274 | |||||||||
WBPaper00016345 | |||||||||
WBPaper00016947 | |||||||||
WBPaper00017001 | |||||||||
WBPaper00017177 | |||||||||
WBPaper00017632 | |||||||||
WBPaper00018321 | |||||||||
WBPaper00018322 | |||||||||
WBPaper00019448 | |||||||||
WBPaper00021781 | |||||||||
WBPaper00021948 | |||||||||
WBPaper00022558 | |||||||||
WBPaper00023308 | |||||||||
WBPaper00023449 | |||||||||
WBPaper00023610 | |||||||||
WBPaper00023758 | |||||||||
WBPaper00024147 | |||||||||
WBPaper00024148 | |||||||||
WBPaper00024530 | |||||||||
WBPaper00024779 | |||||||||
WBPaper00024809 | |||||||||
WBPaper00024814 | |||||||||
WBPaper00025148 | |||||||||
WBPaper00025762 | |||||||||
WBPaper00025979 | |||||||||
WBPaper00026154 | |||||||||
WBPaper00026319 | |||||||||
WBPaper00027089 | |||||||||
WBPaper00028231 | |||||||||
WBPaper00028761 | |||||||||
WBPaper00029012 | |||||||||
WBPaper00029130 | |||||||||
WBPaper00030363 | |||||||||
WBPaper00030960 | |||||||||
WBPaper00031010 | |||||||||
WBPaper00031252 | |||||||||
WBPaper00031930 | |||||||||
WBPaper00031996 | |||||||||
WBPaper00032366 | |||||||||
WBPaper00032681 | |||||||||
WBPaper00032686 | |||||||||
WBPaper00032712 | |||||||||
WBPaper00033361 | |||||||||
WBPaper00034738 | |||||||||
WBPaper00035074 | |||||||||
WBPaper00035150 | |||||||||
WBPaper00035548 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00039265 | |||||||||
WBPaper00041069 | |||||||||
WBPaper00041227 | |||||||||
WBPaper00041959 | |||||||||
WBPaper00043908 | |||||||||
WBPaper00046216 | |||||||||
WBPaper00047128 | |||||||||
WBPaper00053123 | |||||||||
WBPaper00054426 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00058964 | |||||||||
WBPaper00061589 | |||||||||
WBPaper00062181 | |||||||||
WBPaper00064181 | |||||||||
WBPaper00064302 | |||||||||
WBPaper00065144 | |||||||||
Method | Gene |