WormBase Tree Display for Gene: WBGene00002348

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WBGene00002348	SMap	S_parent	Sequence	CHROMOSOME_I
	Identity	Version	2
		Name	CGC_name	myo-1	Person_evidence	WBPerson261
			Sequence_name	R06C7.10
			Molecular_name	R06C7.10
				R06C7.10.1
				CE06253
			Other_name	myosin I	Accession_evidence	EMBL	M37234
				CELE_R06C7.10	Accession_evidence	NDB	BX284601
			Public_name	myo-1
		DB_info	Database	AceView	gene	1H836
				WormQTL	gene	WBGene00002348
				WormFlux	gene	WBGene00002348
				NDB	locus_tag	CELE_R06C7.10
				Panther	gene	CAEEL\|WormBase=WBGene00002348\|UniProtKB=P02567
					family	PTHR45615
				NCBI	gene	172471
				RefSeq	protein	NM_059652.7
				SwissProt	UniProtAcc	P02567
				UniProt_GCRP	UniProtAcc	P02567
				OMIM	gene	160720
						160740
						160741
						160760
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:27	WBPerson1971	Event	Imported	Initial conversion from geneace
				2	20 Oct 2010 10:47:45	WBPerson2970	Event	Split_into	WBGene00202503
			Split_into	WBGene00202503
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	myo
		Allele (90)
		Strain	WBStrain00051410
		RNASeq_FPKM (74)
		GO_annotation (23)
		Ortholog (83)
		Paralog (21)
		Structured_description	Automated_description	A structural constituent of muscle. Involved in muscle contraction and pharyngeal pumping. Located in striated muscle myosin thick filament. Expressed in pharynx. Human ortholog(s) of this gene implicated in several diseases, including contractures, pterygia, and spondylocarpotarsal fusion syndrome 1A; distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model (23)
	Molecular_info	Corresponding_CDS	R06C7.10
		Corresponding_transcript	R06C7.10.1
		Other_sequence (55)
		Associated_feature (15)
	Experimental_info	RNAi_result	WBRNAi00051383	Inferred_automatically	RNAi_primary
			WBRNAi00060113	Inferred_automatically	RNAi_primary
			WBRNAi00026040	Inferred_automatically	RNAi_primary
			WBRNAi00066667	Inferred_automatically	RNAi_primary
			WBRNAi00060111	Inferred_automatically	RNAi_primary
			WBRNAi00060112	Inferred_automatically	RNAi_primary
			WBRNAi00060110	Inferred_automatically	RNAi_primary
			WBRNAi00022415	Inferred_automatically	RNAi_primary
			WBRNAi00066718	Inferred_automatically	RNAi_primary
			WBRNAi00026041	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr2731
			Expr1014691
			Expr1031351
			Expr1155073
			Expr2013841
			Expr2032081
		Antibody	WBAntibody00000012
		Microarray_results (19)
		Expression_cluster	WBPaper00024704:Soluble_protein
			WBPaper00024970:GABAergic_neuron_specific
			WBPaper00031040:TGF-beta_adult_upregulated
			WBPaper00032528:L3_enriched
			WBPaper00035073:mitochondria_protein
			WBPaper00036375:enriched_in_PVD_OLL
			WBPaper00036662:oxidative_modification
			WBPaper00037047:aging_accelerated_insoluble_protein
			WBPaper00037047:insoluble_protein
			WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:hypodermis_L1-larva_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:pharyngeal-muscle_embryo_enriched
			WBPaper00037950:pharyngeal-muscle_embryo_SelectivelyEnriched
			WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
			WBPaper00038061:aldicarb_downregulated
			WBPaper00038289:oocyte_protein
			WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
			WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
			WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
			WBPaper00041954:ethanol_upregulated
			WBPaper00042215:wdr-23(tm1817)_upregulated
			WBPaper00042561:smg-2(RNAi)_upregulated
			WBPaper00042561:smgl-1(RNAi)_upregulated
			WBPaper00042561:smgl-2(RNAi)_upregulated
			WBPaper00043945:MeHg_downregulated
			WBPaper00043951:insoluble_protein_day16_N2
			WBPaper00044037:eat-2_upregulated
			WBPaper00044128:DietaryRestriction_upregulated
			WBPaper00044260:1-methylnicotinamide_upregulated
			WBPaper00044260:nicotinc-acid_upregulated
			WBPaper00044656:tatn-1(qd182)_upregulated
			WBPaper00044736:oscillating_dev_expression
			WBPaper00044743:wdr-23_neuron_upregulated
			WBPaper00044746:aging_downregulated_Day5
			WBPaper00044746:aging_downregulated_Day10
			WBPaper00044746:aging_downregulated_HeatShock
			WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
			WBPaper00045521:Gender_Neutral
			WBPaper00045934:wrn-1(gk99)_upregulated
			WBPaper00046446:rapid-synthesized_AgingAdult
			WBPaper00046446:slow-synthesized_YoungAdult
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_upregulated_protein
			WBPaper00046858:elt-2(RNAi)_downregulated
			WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
			WBPaper00047131:daf-2(e1370)_upregulated_N2-background
			WBPaper00047132:glp-1(ts)-25C_upregulated
			WBPaper00048988:neuron_expressed
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated
			WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
			WBPaper00049920:hyl-2(tm2031)_upregulated
			WBPaper00049942:HeatShock_upregulated_hsf-1(+)
			WBPaper00049942:hsf-1(RNAi)_upregulated
			WBPaper00050015:ifg-1(RNAi)_upregulated
			WBPaper00050080:rbr-2(tm3141)_downregulated
			WBPaper00050636:aging_regulated_insoluble_protein
			WBPaper00050698:DEP-1_interacting
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050726:OsmoticStress_regulated_NoFood
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:body-muscle_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00050990:pharynx_expressed
			WBPaper00051265:F4_hrde-1(tm1200)_upregulated
			WBPaper00051461:pig-1(gm344)_downregulated
			WBPaper00051555:atm-1(gk186)_regulated_protein
			WBPaper00052884:emb-4(hc60)_upregulated
			WBPaper00053184:sma-2(rax5)_upregulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053295:lin-22(ot269)_downregulated
			WBPaper00053302:alovudine_72h_regulated
			WBPaper00053302:stavudine_24h_regulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053318:Aging_downregulated_mRNA_N2
			WBPaper00053657:N2_M.humicola-infection_24hr
			WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00053810:isp-1(qm150)_downregulated
			WBPaper00055334:DLC-1_interacting
			WBPaper00055354:eat-2(ad1116)_upregulated
			WBPaper00055354:Rapamycin-Allantoin_upregulated
			WBPaper00055354:Rapamycin-Psora_upregulated
			WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
			WBPaper00055354:Rapamycin_upregulated
			WBPaper00055354:Rifampicin_downregulated
			WBPaper00055386:daf-2(e1370)_upregulated
			WBPaper00055386:eat-2(ad465)_upregulated
			WBPaper00055482:Tunicamycin_downregulated
			WBPaper00055648:anterior-head_expressed
			WBPaper00055648:pharynx_expressed
			WBPaper00055827:pfd-6(gk493446)_downregulated
			WBPaper00055862:antimycin_damt-1(gk961032)_regulated
			WBPaper00055971:nhl-2(ok818)_20C_downregulated
			WBPaper00055981:fog-2(q71)_downregulated
			WBPaper00056034:pals-22(jy3)_upregulated
			WBPaper00056039:hda-6(ok3203)_upregulated
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056090:E.faecalis_upregulated_N2
			WBPaper00056443:DietaryRestriction_downregulated
			WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
			WBPaper00056471:S.aureus-4h_upregulated_N2
			WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
			WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
			WBPaper00056900:ERH-2_interacting
			WBPaper00056900:PID-3_interacting
			WBPaper00056900:TOFU-6_interacting
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00056997:NMAD-1_interacting
			WBPaper00057006:DietaryRestriction_upregulated
			WBPaper00057041:unc-70(cas983)_downregulated
			WBPaper00057143:ztf-11(RNAi)_upregulated
			WBPaper00057288:Cold_downregulated_protein
			WBPaper00058598:mex-1(or286)_upregulated
			WBPaper00058598:mex-3(eu149)_upregulated
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058598:spn-4(tm291)_upregulated
			WBPaper00058665:graphene-oxide_downregulated_mRNA
			WBPaper00058678:DAF-12_upregulated_PVD
			WBPaper00058725:sftb-1(cer6)_downregulated
			WBPaper00058948:npr-8(ok1439)_downregulated_OP50
			WBPaper00058958:100mGy-irradiation-72h_upregulated
			WBPaper00058969:RIS_depleted
			WBPaper00059117:B.subtilis_upregulated
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059421:daf-1(m40)_upregulated
			WBPaper00059566:wdr-23(mac32)_upregulated
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00059728:5ug_cholesterol_upregulated
			WBPaper00059728:20ug_cholesterol_upregulated
			WBPaper00059739:hira-1(gk835598)_upregulated_adult
			WBPaper00059824:rnp-6(dh1127)_regulated_OP50
			WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
			WBPaper00060100:SiNP_upregulated_mRNA
			WBPaper00060459:bcat-1(RNAi)_upregulated
			WBPaper00060661:hypoxia_downregulated
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00060909:atfs-1(et18)_downregulated
			WBPaper00061007:HB115_upregulated
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061340:AVL
			WBPaper00061340:g1A
			WBPaper00061340:PLM
			WBPaper00061340:RIS
			WBPaper00061341:28C_24h_upregulated
			WBPaper00061341:28C_48h_upregulated
			WBPaper00061377:MYRF-1_interacting
			WBPaper00061377:MYRF-2_interacting
			WBPaper00061377:PAN-1_interacting
			WBPaper00061424:Diet_MYb120_upregulated
			WBPaper00061466:nath-10(icb99)_upregulated
			WBPaper00061479:hda-1(ne4752)_upregulated
			WBPaper00061479:hrde-1(tm1200)_upregulated
			WBPaper00061527:tnt-4-myo-1_2160
			WBPaper00061753:csr-1(tor159)_downregulated_25C
			WBPaper00061818:AFD_enriched_protein
			WBPaper00061818:ELKS-1_interacting
			WBPaper00061995:mter-4(syb3662syb3403)_downregulated
			WBPaper00062118:neural-HSF-1_downregulated
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062193:skn-1(RNAi)_upregulated
			WBPaper00062325:muscle_depleted_coding-RNA
			WBPaper00062554:MAGU-2_interacting
			WBPaper00062590:Aging_upregulated_intestine
			WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
			WBPaper00064055:trl-1(cas1077)_upregulated_starved
			WBPaper00064055:trl-1(cas10778)_upregulated_non-starved
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
			WBPaper00064156:lbp-3(overexpress)_upregulated
			WBPaper00064201:SNA-1_interacting
			WBPaper00064201:SNA-3_interacting
			WBPaper00064306:Agaro-oligosaccharides_upregulated
			WBPaper00064532:pals-22(jy3)_downregulated
			WBPaper00064624:iHg-induced_aggregome
			WBPaper00064716:paraquat_downregulated
			WBPaper00064721:fasn-1(g14)_downregulated_starved
			WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
			WBPaper00065096:25C_vs_20C_downregulated
			WBPaper00065096:Day10_vs_Day1_downregulated
			WBPaper00065120:body-muscle-transcriptome
			WBPaper00065149:lin-52(n771)_downregulated
			WBPaper00065158:AFD_enriched
			WBPaper00065373:Cisplatin_downregulated_WT
			WBPaper00065373:sek-1(km4)_upregulated_cisplatin
			WBPaper00065581:hpk-1(pk1393)_upregulated
			WBPaper00065759:dot-1.1(knu339)_upregulated
			WBPaper00065835:Day5_vs_Day1_downregulated
			WBPaper00065835:Day11_vs_Day1_downregulated
			WBPaper00065841:24_0
			WBPaper00065841:24_1
			WBPaper00065841:26_0
			WBPaper00065841:26_1
			WBPaper00065841:26_2
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00065993:glp-1(e2141)_upregulated
			WBPaper00066038:mip-1(how5)_upregulated
			WBPaper00066085:sin-3(tm1276)_downregulated
			WBPaper00066110:Cisplatin_upregulated_diploid
			WBPaper00066110:tetraploid_vs_diploid_upregulated
			cgc4386_cluster_2_4
			cgc4489_group_20
			WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00028789:PA14_vs_gacA_downregulated_4hr
			WBPaper00028789:PA14_vs_OP50_downregulated_4hr
			WBPaper00031003:0hr_muscle_depleted
			WBPaper00031003:total_muscle_depleted
			WBPaper00031532:Larva_Pan_Neuronal_Depleted
			WBPaper00034661:AgNPs_downregulated
			WBPaper00036123:Cadmium_regulated
			WBPaper00036286:Pattern_C
			WBPaper00037695:WC_5-day
			WBPaper00038427:lin-54_embryo_changed
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00040821:Au-NP_regulated
			WBPaper00040858:eQTL_regulated_old
			WBPaper00040858:eQTL_regulated_reproductive
			WBPaper00040963:TA100_up
			WBPaper00040963:TA200_up
			WBPaper00040963:TA300_up
			WBPaper00041002:HQ_3d_0.2mM_Up
			WBPaper00041002:HQ_3d_2.0mM_Up
			WBPaper00041267:SpaceFlight_Downregulated
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00042574:rde-1(ne219)_OrsayVirus_upregulated
			WBPaper00047070:N2_starvation_upregulated
			WBPaper00047070:N2_UV_upregulated
			WBPaper00048624:hlh-25(ok1710)_upregulated
			WBPaper00048989:N2_allantoin_downregulated
			WBPaper00050650:mBmkTX_downregulated
			WBPaper00055435:MUA-AuNP-3_downregulated
			WBPaper00056330:mrps-5(RNAi)_upregulated
			[cgc6390]:Cluster_C
		Interaction (143)
	Map_info	Positive	Positive_clone	R06C7	Inferred_automatically	From sequence, transcript, pseudogene data
				SG25/26
		Mapping_data	2_point	5116
				5117
			Multi_point	279
				814
				1784
				4477
				5056
			Pos_neg_data (12)
		Interpolated_map_position	I	1.86572
	Reference (61)
	Remark	yk10b9.3 removed from sequence list. sdm 11/00
		let-75 was previously renamed to myo-1, but has been reverted back to let-75 due to historical precedence [021117 ck1]
	Method	Gene