WormBase Tree Display for Gene: WBGene00002285
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| WBGene00002285 | Evidence | CGC_data_submission | |||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C05G5 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | let-7 | Person_evidence | WBPerson533 | |||||
| Sequence_name | C05G5.6 | ||||||||
| Molecular_name | C05G5.6 | ||||||||
| C05G5.6.1 | |||||||||
| C05G5.6.2 | |||||||||
| C05G5.6.3 | |||||||||
| C05G5.6a | |||||||||
| C05G5.6b | |||||||||
| Other_name | Cel-Let-7-P5 | Remark | MirGeneDB 2.1 import | ||||||
| CELE_C05G5.6 | Accession_evidence | NDB | BX284606 | ||||||
| Public_name | let-7 | ||||||||
| DB_info | Database | SignaLink | mirna | cel-let-7 | |||||
| MirGeneDB | cel | Cel-Let-7-P5 | |||||||
| NDB | locus_tag | CELE_C05G5.6 | |||||||
| NCBI | gene | 266952 | |||||||
| RefSeq | protein | NR_000938.3 | |||||||
| RNAcentral | URSid | URS00000050A9 | |||||||
| URS000039D791 | |||||||||
| URS0000416056 | |||||||||
| URS000048591D | |||||||||
| URS00004D9B56 | |||||||||
| URS000077133B | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (11) | |||||||||
| Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00003929 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 25 Oct 2018 00:00:00 | ||||||||
| Disease_relevance | let-7 microRNA (miRNA) is highly conserved across species, from C. elegans to humans; there are at least 13 different let-7 family members in humans, C. elegans let-7 being identical to human let-7a; let-7 is generally believed to be a tumor suppressor miRNA, as expression of let-7 family members are down-regulated in many cancers, including lung, breast, ovarian, and prostate cancers, and melanoma, when compared to normal tissues; however upregulation of certain let-7 family members has been observed in a few cancers, indicating that let-7 may not play a tumor suppressor role in all tissues/circumstances; human let-7 targets several cancer-relevant targets for repression including: the RAS/let-60 gene (upregulated in lung cancers), HMGA2, a chromatin-associated non-histone protein, IGF2 mRNA binding protein (IMP1), and lin28B; studies in elegans indicate that let-7 and let-7 miRNA family members and their target genes regulate the expression of the amyloid precursor protein-like, apl-1, (orthologous to human APP), which may provide insights into the progression of Alzheimer''s disease. | Homo sapiens | Paper_evidence | WBPaper00035291 | |||||
| WBPaper00031506 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 18 Dec 2013 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000256 | ||||||||
| Molecular_info | Corresponding_transcript | C05G5.6 | |||||||
| C05G5.6.1 | |||||||||
| C05G5.6.2 | |||||||||
| C05G5.6.3 | |||||||||
| C05G5.6a | |||||||||
| C05G5.6b | |||||||||
| Corresponding_transcript_history | C05G5.6:wp135 | ||||||||
| Associated_feature | WBsf718850 | ||||||||
| WBsf979137 | |||||||||
| WBsf1007993 | |||||||||
| Gene_product_binds (20) | |||||||||
| Experimental_info | Expr_pattern (20) | ||||||||
| Drives_construct (16) | |||||||||
| Construct_product (28) | |||||||||
| Regulate_expr_cluster | WBPaper00042165:let-7_downregulated | ||||||||
| WBPaper00042165:let-7_upregulated | |||||||||
| WBPaper00044501:gld-1_let-7_regulated | |||||||||
| WBPaper00050717:let-7(n2853)_lin-41(xe11)_downregulated | |||||||||
| WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated | |||||||||
| WBPaper00064080:let-7_miRNA_interacting | |||||||||
| Expression_cluster (39) | |||||||||
| Interaction (449) | |||||||||
| WBProcess | WBbiopr:00000020 | ||||||||
| WBbiopr:00000057 | |||||||||
| WBbiopr:00000081 | |||||||||
| WBbiopr:00000083 | |||||||||
| Map_info | Map | X | Position | 21.2192 | Error | 0.067046 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C05G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 192 | |||||||
| Multi_point | 188 | ||||||||
| 4742 | |||||||||
| Pos_neg_data | 2068 | ||||||||
| 2096 | |||||||||
| 2200 | |||||||||
| 2205 | |||||||||
| 2212 | |||||||||
| 2218 | |||||||||
| 2224 | |||||||||
| 2275 | |||||||||
| 2279 | |||||||||
| Reference (475) | |||||||||
| Remark | Sequence connection from [Reinhart BJ, Slack FJ] | ||||||||
| Rfam accession number: MI0000001 | |||||||||
| Method | Gene |
