WormBase Tree Display for Gene: WBGene00002285
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WBGene00002285 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C05G5 | ||||
Identity (6) | |||||||
Gene_info (11) | |||||||
Disease_info | Experimental_model | DOID:162 | Homo sapiens | Paper_evidence | WBPaper00003929 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 25 Oct 2018 00:00:00 | ||||||
Disease_relevance | let-7 microRNA (miRNA) is highly conserved across species, from C. elegans to humans; there are at least 13 different let-7 family members in humans, C. elegans let-7 being identical to human let-7a; let-7 is generally believed to be a tumor suppressor miRNA, as expression of let-7 family members are down-regulated in many cancers, including lung, breast, ovarian, and prostate cancers, and melanoma, when compared to normal tissues; however upregulation of certain let-7 family members has been observed in a few cancers, indicating that let-7 may not play a tumor suppressor role in all tissues/circumstances; human let-7 targets several cancer-relevant targets for repression including: the RAS/let-60 gene (upregulated in lung cancers), HMGA2, a chromatin-associated non-histone protein, IGF2 mRNA binding protein (IMP1), and lin28B; studies in elegans indicate that let-7 and let-7 miRNA family members and their target genes regulate the expression of the amyloid precursor protein-like, apl-1, (orthologous to human APP), which may provide insights into the progression of Alzheimer''s disease. | Homo sapiens | Paper_evidence | WBPaper00035291 | |||
WBPaper00031506 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 18 Dec 2013 00:00:00 | ||||||
Models_disease_in_annotation | WBDOannot00000256 | ||||||
Molecular_info | Corresponding_transcript | C05G5.6 | |||||
C05G5.6.1 | |||||||
C05G5.6.2 | |||||||
C05G5.6.3 | |||||||
C05G5.6a | |||||||
C05G5.6b | |||||||
Corresponding_transcript_history | C05G5.6:wp135 | ||||||
Associated_feature | WBsf718850 | ||||||
WBsf979137 | |||||||
WBsf1007993 | |||||||
Gene_product_binds (20) | |||||||
Experimental_info | Expr_pattern (20) | ||||||
Drives_construct (16) | |||||||
Construct_product (28) | |||||||
Regulate_expr_cluster | WBPaper00042165:let-7_downregulated | ||||||
WBPaper00042165:let-7_upregulated | |||||||
WBPaper00044501:gld-1_let-7_regulated | |||||||
WBPaper00050717:let-7(n2853)_lin-41(xe11)_downregulated | |||||||
WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated | |||||||
WBPaper00064080:let-7_miRNA_interacting | |||||||
Expression_cluster (39) | |||||||
Interaction (449) | |||||||
WBProcess | WBbiopr:00000020 | ||||||
WBbiopr:00000057 | |||||||
WBbiopr:00000081 | |||||||
WBbiopr:00000083 | |||||||
Map_info | Map | X | Position | 21.2192 | Error | 0.067046 | |
Well_ordered | |||||||
Positive | Positive_clone | C05G5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | 2_point | 192 | |||||
Multi_point | 188 | ||||||
4742 | |||||||
Pos_neg_data | 2068 | ||||||
2096 | |||||||
2200 | |||||||
2205 | |||||||
2212 | |||||||
2218 | |||||||
2224 | |||||||
2275 | |||||||
2279 | |||||||
Reference (475) | |||||||
Remark | Sequence connection from [Reinhart BJ, Slack FJ] | ||||||
Rfam accession number: MI0000001 | |||||||
Method | Gene |