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WormBase Tree Display for Gene: WBGene00002244

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Name Class

WBGene00002244SMapS_parentSequenceY71H2AM
IdentityVersion2
NameCGC_namelaf-1Paper_evidenceWBPaper00033079
Person_evidenceWBPerson213
Sequence_nameY71H2AM.19
Molecular_nameY71H2AM.19
Y71H2AM.19.1
CE47305
Other_nameCELE_Y71H2AM.19Accession_evidenceNDBBX284603
Public_namelaf-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:27WBPerson1971EventImportedInitial conversion from geneace
207 May 2009 15:45:20WBPerson1847EventAcquires_mergeWBGene00022184
Acquires_mergeWBGene00022184
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlaf
Allele (319)
Possibly_affected_byWBVar02154084
StrainWBStrain00003812
RNASeq_FPKM (74)
GO_annotation (43)
Ortholog (43)
Paralog (37)
Structured_descriptionConcise_descriptionlaf-1 encodes a DEAD-box RNA helicase; laf-1 is required for embryonic development and sex determination; laf-1 was identified in screens for dominant suppressors of the sterility produced by gain-of-function fem-3 mutations; when homozygous, laf-1 mutations result in embryonic and larval lethality and when heterozygous, feminization of XX and XO animals; reporter gene analyses indicate that wild-type laf-1 activity is required for proper translational repression of tra-2 mRNA via its 3'UTR; when expressed in embryos, LAF-1 localizes predominantly to the cytoplasm with additional localization seen in P granules.Paper_evidenceWBPaper00002662
WBPaper00033079
Curator_confirmedWBPerson1843
Date_last_updated09 Sep 2009 00:00:00
Automated_descriptionEnables RNA strand annealing activity; identical protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule. Expressed in germ line. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and syndromic X-linked intellectual disability. Is an ortholog of human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2745)
DOID:0060309Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2745)
DOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2745)
Molecular_infoCorresponding_CDSY71H2AM.19
Corresponding_CDS_historyY71H2AM.19a:wp275
Corresponding_transcriptY71H2AM.19.1
Other_sequence (56)
Associated_featureWBsf976054
WBsf991601
WBsf991602
WBsf1014456
WBsf1014457
WBsf226303
WBsf226304
Experimental_infoRNAi_resultWBRNAi00058241Inferred_automaticallyRNAi_primary
WBRNAi00116331Inferred_automaticallyRNAi_primary
WBRNAi00075501Inferred_automaticallyRNAi_primary
WBRNAi00058240Inferred_automaticallyRNAi_primary
WBRNAi00116333Inferred_automaticallyRNAi_primary
WBRNAi00078430Inferred_automaticallyRNAi_primary
WBRNAi00078432Inferred_automaticallyRNAi_primary
WBRNAi00116332Inferred_automaticallyRNAi_primary
Expr_patternExpr8592
Expr1013835
Expr1031318
Expr1161659
Expr2013003
Expr2031235
Drives_constructWBCnstr00042407
Construct_productWBCnstr00042407
AntibodyWBAntibody00002638
Microarray_results (27)
Expression_clusterWBPaper00032031:DConiospora_upregulated_OligoArray_24h
WBPaper00034640:Phosphorylated_protein
WBPaper00037047:insoluble_protein
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:bodywall-muscle_L2-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:intestine_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038118:aak-2(gt33)_upregulated
WBPaper00038289:oocyte_protein
WBPaper00040221:DAF-12_target_ALF4
WBPaper00041072:UTX-1_interacting_protein
WBPaper00044037:eat-2_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045316:prg-1_upregulated_L1
WBPaper00045316:prg-1_upregulated_L2
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046499:AMPK_regulated
WBPaper00046509:htz-1(ok3099)_downregulated
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00047131:daf-2(e1370)_downregulated_N2-background
WBPaper00048988:neuron_expressed
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049732:blmp-1(tm548)_vs_N2_upregulated
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00050234:lin-28(RNAi)_upregulated
WBPaper00050686:glp-1(e2141)_downregulated
WBPaper00050698:DEP-1_interacting
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051039:germline_enriched
WBPaper00051245:body-wall-muscle_cytoplasm_expressed
WBPaper00051245:epidermis_cytoplasm_expressed
WBPaper00051245:epidermis_nucleus_expressed
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051265:F1_morc-1(tm6048)_downregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:zidovudine_24h_regulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_upregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_downregulated
WBPaper00053810:daf-2(e1370)_downregulated
WBPaper00053810:isp-1(qm150)_downregulated
WBPaper00053810:nuo-6(qm200)_downregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055482:pmt-2(RNAi)_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055648:germline_expressed
WBPaper00055941:nuo-6(qm200)_downregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056284:INTS-6_interacting_protein
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057041:unc-70(cas983)_upregulated
WBPaper00057288:Cold_downregulated_protein
WBPaper00057288:Cold_downregulated_transcript
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00058691:CFP-1_interacting_protein
WBPaper00058691:WDR-5.1_interacting_protein
WBPaper00058958:100mGy-irradiation-72h_upregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059605:MUT-16_interacting
WBPaper00060100:SiNP_upregulated_mRNA
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060908:TEBP-2_interacting
WBPaper00061341:28C_24h_downregulated
WBPaper00061341:28C_48h_downregulated
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:pro-3_11683-C44E4.1_9745
WBPaper00062143:PQN-59_interacting
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062498:PPM-1.D_interacting
WBPaper00062554:MAGU-2_interacting
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064055:trl-1(cas1077)_upregulated_non-starved
WBPaper00064055:trl-1(cas1077)_upregulated_starved
WBPaper00064071:NHR-49_interacting
WBPaper00064716:paraquat_upregulated
WBPaper00064871:hypoxia_upregulated_F2
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
WBPaper00030985:Erwinia_carotovora_downregulated
WBPaper00030985:Serratia_marcesens_downregulated
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Depleted
WBPaper00036286:Pattern_D
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_regulated_old
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041609:hpl-1_hpl-2_downregulated
WBPaper00041939:control_vs_EtBr-exposed_3h
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_3h
WBPaper00042128:gei-8(ok1671)_downregulated
WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
WBPaper00048989:N2_rapamycin_upregulated
Interaction (55)
Map_infoMapIIIPosition-10.2047Error0.03232
PositivePositive_cloneY71H2AMInferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point7053
Multi_point3526
Reference (44)
MethodGene