WormBase Tree Display for Gene: WBGene00002244
expand all nodes | collapse all nodes | view schema
| WBGene00002244 | SMap | S_parent | Sequence | Y71H2AM | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | laf-1 | Paper_evidence | WBPaper00033079 | |||||
| Person_evidence | WBPerson213 | ||||||||
| Sequence_name | Y71H2AM.19 | ||||||||
| Molecular_name | Y71H2AM.19 | ||||||||
| Y71H2AM.19.1 | |||||||||
| CE47305 | |||||||||
| Other_name | CELE_Y71H2AM.19 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | laf-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 07 May 2009 15:45:20 | WBPerson1847 | Event | Acquires_merge | WBGene00022184 | ||||
| Acquires_merge | WBGene00022184 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | laf | ||||||||
| Allele (319) | |||||||||
| Possibly_affected_by | WBVar02154084 | ||||||||
| Strain | WBStrain00003812 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (43) | |||||||||
| Ortholog (43) | |||||||||
| Paralog (37) | |||||||||
| Structured_description | Concise_description | laf-1 encodes a DEAD-box RNA helicase; laf-1 is required for embryonic development and sex determination; laf-1 was identified in screens for dominant suppressors of the sterility produced by gain-of-function fem-3 mutations; when homozygous, laf-1 mutations result in embryonic and larval lethality and when heterozygous, feminization of XX and XO animals; reporter gene analyses indicate that wild-type laf-1 activity is required for proper translational repression of tra-2 mRNA via its 3'UTR; when expressed in embryos, LAF-1 localizes predominantly to the cytoplasm with additional localization seen in P granules. | Paper_evidence | WBPaper00002662 | |||||
| WBPaper00033079 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Sep 2009 00:00:00 | ||||||||
| Automated_description | Enables RNA strand annealing activity; identical protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule. Expressed in germ line. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and syndromic X-linked intellectual disability. Is an ortholog of human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||
| DOID:0060309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||||
| Molecular_info | Corresponding_CDS | Y71H2AM.19 | |||||||
| Corresponding_CDS_history | Y71H2AM.19a:wp275 | ||||||||
| Corresponding_transcript | Y71H2AM.19.1 | ||||||||
| Other_sequence (56) | |||||||||
| Associated_feature | WBsf976054 | ||||||||
| WBsf991601 | |||||||||
| WBsf991602 | |||||||||
| WBsf1014456 | |||||||||
| WBsf1014457 | |||||||||
| WBsf226303 | |||||||||
| WBsf226304 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00058241 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00116331 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00075501 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00058240 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116333 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078430 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00078432 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116332 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr8592 | ||||||||
| Expr1013835 | |||||||||
| Expr1031318 | |||||||||
| Expr1161659 | |||||||||
| Expr2013003 | |||||||||
| Expr2031235 | |||||||||
| Drives_construct | WBCnstr00042407 | ||||||||
| Construct_product | WBCnstr00042407 | ||||||||
| Antibody | WBAntibody00002638 | ||||||||
| Microarray_results (27) | |||||||||
| Expression_cluster (127) | |||||||||
| Interaction (55) | |||||||||
| Map_info | Map | III | Position | -10.2047 | Error | 0.03232 | |||
| Positive | Positive_clone | Y71H2AM | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 7053 | |||||||
| Multi_point | 3526 | ||||||||
| Reference (44) | |||||||||
| Method | Gene |
