WormBase Tree Display for Gene: WBGene00002244
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WBGene00002244 | SMap | S_parent | Sequence | Y71H2AM | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | laf-1 | Paper_evidence | WBPaper00033079 | |||||
Person_evidence | WBPerson213 | ||||||||
Sequence_name | Y71H2AM.19 | ||||||||
Molecular_name | Y71H2AM.19 | ||||||||
Y71H2AM.19.1 | |||||||||
CE47305 | |||||||||
Other_name | CELE_Y71H2AM.19 | Accession_evidence | NDB | BX284603 | |||||
Public_name | laf-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 07 May 2009 15:45:20 | WBPerson1847 | Event | Acquires_merge | WBGene00022184 | ||||
Acquires_merge | WBGene00022184 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | laf | ||||||||
Allele (319) | |||||||||
Possibly_affected_by | WBVar02154084 | ||||||||
Strain | WBStrain00003812 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (43) | |||||||||
Ortholog (43) | |||||||||
Paralog (37) | |||||||||
Structured_description | Concise_description | laf-1 encodes a DEAD-box RNA helicase; laf-1 is required for embryonic development and sex determination; laf-1 was identified in screens for dominant suppressors of the sterility produced by gain-of-function fem-3 mutations; when homozygous, laf-1 mutations result in embryonic and larval lethality and when heterozygous, feminization of XX and XO animals; reporter gene analyses indicate that wild-type laf-1 activity is required for proper translational repression of tra-2 mRNA via its 3'UTR; when expressed in embryos, LAF-1 localizes predominantly to the cytoplasm with additional localization seen in P granules. | Paper_evidence | WBPaper00002662 | |||||
WBPaper00033079 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 09 Sep 2009 00:00:00 | ||||||||
Automated_description | Enables RNA strand annealing activity; identical protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including masculinization of hermaphroditic germ-line; positive regulation of embryonic development; and positive regulation of fertilization. Located in P granule. Expressed in germ line. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and syndromic X-linked intellectual disability. Is an ortholog of human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||
DOID:0060309 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||||
DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2745) | ||||||
Molecular_info | Corresponding_CDS | Y71H2AM.19 | |||||||
Corresponding_CDS_history | Y71H2AM.19a:wp275 | ||||||||
Corresponding_transcript | Y71H2AM.19.1 | ||||||||
Other_sequence (56) | |||||||||
Associated_feature | WBsf976054 | ||||||||
WBsf991601 | |||||||||
WBsf991602 | |||||||||
WBsf1014456 | |||||||||
WBsf1014457 | |||||||||
WBsf226303 | |||||||||
WBsf226304 | |||||||||
Experimental_info | RNAi_result | WBRNAi00058241 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116331 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075501 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00058240 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00116333 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078430 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00078432 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00116332 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern (6) | |||||||||
Drives_construct | WBCnstr00042407 | ||||||||
Construct_product | WBCnstr00042407 | ||||||||
Antibody | WBAntibody00002638 | ||||||||
Microarray_results (27) | |||||||||
Expression_cluster (127) | |||||||||
Interaction (55) | |||||||||
Map_info | Map | III | Position | -10.2047 | Error | 0.03232 | |||
Positive | Positive_clone | Y71H2AM | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 7053 | |||||||
Multi_point | 3526 | ||||||||
Reference (44) | |||||||||
Method | Gene |