WormBase Tree Display for Gene: WBGene00002227
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| WBGene00002227 | SMap | S_parent | Sequence | W02B12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | klp-17 | Person_evidence | WBPerson589 | |||||
| Sequence_name | W02B12.7 | ||||||||
| Molecular_name | W02B12.7 | ||||||||
| W02B12.7.1 | |||||||||
| CE37934 | |||||||||
| Other_name | CELE_W02B12.7 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | klp-17 | ||||||||
| DB_info | Database | AceView | gene | 2L756 | |||||
| WormQTL | gene | WBGene00002227 | |||||||
| WormFlux | gene | WBGene00002227 | |||||||
| NDB | locus_tag | CELE_W02B12.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002227|UniProtKB=Q23124 | |||||||
| family | PTHR47972 | ||||||||
| NCBI | gene | 174750 | |||||||
| RefSeq | protein | NM_064045.6 | |||||||
| TREEFAM | TREEFAM_ID | TF320932 | |||||||
| TrEMBL | UniProtAcc | Q23124 | |||||||
| UniProt_GCRP | UniProtAcc | Q23124 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 14 Dec 2004 16:41:25 | WBPerson1846 | Event | Split_into | WBGene00044026 | ||||
| Split_into | WBGene00044026 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | klp | ||||||||
| Allele (33) | |||||||||
| Possibly_affected_by | WBVar02153214 | ||||||||
| Strain | WBStrain00032128 | ||||||||
| WBStrain00024311 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (24) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | klp-17 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; by homology, KLP-17 is predicted to function as a minus-end directed motor; loss of klp-17 activity via RNAi results in embryonic lethality generally at the one- or two-cell stage with disorganized mitotic spindles and polyploid nuclei, suggesting that KLP-17 plays a role in chromosome segregation and germline development; in situ hybridization studies reveal that klp-17 mRNA is localized specifically to cell nuclei during early development, from the one-cell stage of embryogenesis until early larval stages; a klp-17::gfp transgene did not yield detectable GFP expression, but did result in a small percentage of morphologically abnormal males and intersexual animals that grew slowly and died upon reaching maturity, consistent with a role for klp-17 in chromosome dynamics. | Paper_evidence | WBPaper00003893 | |||||
| WBPaper00003965 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Nov 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable microtubule binding activity. Involved in chromosome segregation. Predicted to be located in microtubule cytoskeleton. Expressed in germ line and sperm. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | W02B12.7 | |||||||
| Corresponding_CDS_history | W02B12.7:wp137 | ||||||||
| Corresponding_transcript | W02B12.7.1 | ||||||||
| Other_sequence | Tcir_isotig17190 | ||||||||
| XI03693 | |||||||||
| FD517427.1 | |||||||||
| Tcir_isotig27917 | |||||||||
| CSC02222_1 | |||||||||
| Associated_feature | WBsf223939 | ||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr982 | ||||||||
| Expr1101 | |||||||||
| Expr15130 | |||||||||
| Expr1023203 | |||||||||
| Expr1158108 | |||||||||
| Expr2012960 | |||||||||
| Expr2031192 | |||||||||
| Drives_construct | WBCnstr00036372 | ||||||||
| Construct_product | WBCnstr00036372 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (109) | |||||||||
| Interaction (43) | |||||||||
| Map_info | Map | II | Position | 3.49314 | Error | 0.002649 | |||
| Positive | Positive_clone | W02B12 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4466 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00003893 | ||||||||
| WBPaper00003965 | |||||||||
| WBPaper00005076 | |||||||||
| WBPaper00015680 | |||||||||
| WBPaper00015683 | |||||||||
| WBPaper00022947 | |||||||||
| WBPaper00025098 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00064797 | |||||||||
| Remark | Sequence connection from [Siddiqui SS], [krb 020711] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
