WormBase Tree Display for Gene: WBGene00002227
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WBGene00002227 | SMap | S_parent | Sequence | W02B12 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | klp-17 | Person_evidence | WBPerson589 | |||
Sequence_name | W02B12.7 | ||||||
Molecular_name | W02B12.7 | ||||||
W02B12.7.1 | |||||||
CE37934 | |||||||
Other_name | CELE_W02B12.7 | Accession_evidence | NDB | BX284602 | |||
Public_name | klp-17 | ||||||
DB_info | Database | AceView | gene | 2L756 | |||
WormQTL | gene | WBGene00002227 | |||||
WormFlux | gene | WBGene00002227 | |||||
NDB | locus_tag | CELE_W02B12.7 | |||||
Panther | gene | CAEEL|WormBase=WBGene00002227|UniProtKB=Q23124 | |||||
family | PTHR47972 | ||||||
NCBI | gene | 174750 | |||||
RefSeq | protein | NM_064045.6 | |||||
TREEFAM | TREEFAM_ID | TF320932 | |||||
TrEMBL | UniProtAcc | Q23124 | |||||
UniProt_GCRP | UniProtAcc | Q23124 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | klp | ||||||
Allele (33) | |||||||
Possibly_affected_by | WBVar02153214 | ||||||
Strain | WBStrain00032128 | ||||||
WBStrain00024311 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (24) | |||||||
Paralog (19) | |||||||
Structured_description | Concise_description | klp-17 encodes a C-terminal kinesin motor protein orthologous to Drosophila NCD and Saccharomyces cerevisiae KAR3; by homology, KLP-17 is predicted to function as a minus-end directed motor; loss of klp-17 activity via RNAi results in embryonic lethality generally at the one- or two-cell stage with disorganized mitotic spindles and polyploid nuclei, suggesting that KLP-17 plays a role in chromosome segregation and germline development; in situ hybridization studies reveal that klp-17 mRNA is localized specifically to cell nuclei during early development, from the one-cell stage of embryogenesis until early larval stages; a klp-17::gfp transgene did not yield detectable GFP expression, but did result in a small percentage of morphologically abnormal males and intersexual animals that grew slowly and died upon reaching maturity, consistent with a role for klp-17 in chromosome dynamics. | Paper_evidence | WBPaper00003893 | |||
WBPaper00003965 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 14 Nov 2005 00:00:00 | ||||||
Automated_description | Predicted to enable microtubule binding activity. Involved in chromosome segregation. Predicted to be located in microtubule cytoskeleton. Expressed in germ line and sperm. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | W02B12.7 | |||||
Corresponding_CDS_history | W02B12.7:wp137 | ||||||
Corresponding_transcript | W02B12.7.1 | ||||||
Other_sequence | Tcir_isotig17190 | ||||||
XI03693 | |||||||
FD517427.1 | |||||||
Tcir_isotig27917 | |||||||
CSC02222_1 | |||||||
Associated_feature | WBsf223939 | ||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr982 | ||||||
Expr1101 | |||||||
Expr15130 | |||||||
Expr1023203 | |||||||
Expr1158108 | |||||||
Expr2012960 | |||||||
Expr2031192 | |||||||
Drives_construct | WBCnstr00036372 | ||||||
Construct_product | WBCnstr00036372 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (109) | |||||||
Interaction (43) | |||||||
Map_info | Map | II | Position | 3.49314 | Error | 0.002649 | |
Positive | Positive_clone | W02B12 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4466 | |||||
Pseudo_map_position | |||||||
Reference | WBPaper00003893 | ||||||
WBPaper00003965 | |||||||
WBPaper00005076 | |||||||
WBPaper00015680 | |||||||
WBPaper00015683 | |||||||
WBPaper00022947 | |||||||
WBPaper00025098 | |||||||
WBPaper00038491 | |||||||
WBPaper00055090 | |||||||
WBPaper00064797 | |||||||
Remark | Sequence connection from [Siddiqui SS], [krb 020711] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |