WormBase Tree Display for Gene: WBGene00002182

WBGene00002182 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 1
    Name: CGC_name: kap-1 Person_evidence: WBPerson589
      Sequence_name: F08F8.3
      Molecular_name: F08F8.3a
        F08F8.3a.1
        CE54188
        F08F8.3b
        CE54084
        F08F8.3a.2
        F08F8.3b.1
      Other_name: CELE_F08F8.3 Accession_evidence: NDB BX284603
      Public_name: kap-1
    DB_info: Database: AceView gene 3I433
        WormQTL gene WBGene00002182
        WormFlux gene WBGene00002182
        NDB locus_tag CELE_F08F8.3
        Panther gene CAEEL|WormBase=WBGene00002182|UniProtKB=H2KZP1
          family PTHR15605
        NCBI gene 176041
        RefSeq protein NM_001379790.1
            NM_001379791.1
        TREEFAM TREEFAM_ID TF314964
        TrEMBL UniProtAcc G5EEE6
            H2KZP1
        UniProt_GCRP UniProtAcc G5EEE6
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: kap
    Allele (67)
    Legacy_information: [Siddiqui SS ]. Related to kinesin associated protein by sequence similarity.
    Strain: WBStrain00003712
      WBStrain00031562
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (38)
    Structured_description: Concise_description: kap-1 encodes a kinesin-associated protein that, along with KLP-20 and KLP-11, is part of the C. elegans heterotrimeric kinesin-II motor protein; animals homozygous for a kap-1 loss-of-function mutation have normal cilia and thus display normal dye-filling and osmotic avoidance behavior; however, animals doubly mutant for kap-1 and osm-3, which encodes a homomeric kinesin-II motor protein, do show defects in intraflagellar transport (IFT) indicating that the heteromeric kinsesin-II and homomeric OSM-3 motor protein complexes function redundantly to effect IFT; antibodies to KAP-1 detect high intensity staining in sensory neuron cilia; kap-1 expression in the AWB sensory neurons is positively regulated by FKH-2. Paper_evidence: WBPaper00003466
            WBPaper00004178
            WBPaper00024501
            WBPaper00029400
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Oct 2008 00:00:00
      Automated_description: Contributes to microtubule motor activity. Involved in intraciliary anterograde transport; negative regulation of non-motile cilium assembly; and positive regulation of non-motile cilium assembly. Located in ciliary transition zone and non-motile cilium. Part of axonemal heterotrimeric kinesin-II complex. Expressed in ciliated neurons. Is an ortholog of human KIFAP3 (kinesin associated protein 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F08F8.3a
      F08F8.3b
    Corresponding_CDS_history: F08F8.3a:wp275
      F08F8.3b:wp275
    Corresponding_transcript: F08F8.3a.1
      F08F8.3a.2
      F08F8.3b.1
    Other_sequence (14)
    Associated_feature: WBsf645332
      WBsf659176
      WBsf976217
      WBsf976218
      WBsf976219
      WBsf976220
      WBsf225239
  Experimental_info: RNAi_result: WBRNAi00012913 Inferred_automatically: RNAi_primary
      WBRNAi00005204 Inferred_automatically: RNAi_primary
      WBRNAi00044028 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct (11)
    Construct_product (16)
    Antibody: WBAntibody00000217
    Microarray_results (21)
    Expression_cluster: WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042194:nhr-114(RNAi)_downregulated
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049954:BPS_upregulated
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050801:DPY-21_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00051352:Long-Term-Association-Memory_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:germline_expressed
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056167:Cry5B_upregulated
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056619:CEPsh_enriched
      WBPaper00056826:hmc_biased
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058691:cfp-1(tm6369)_downregulated
      WBPaper00058691:sin-3(tm1276)_downregulated
      WBPaper00058711:skn-1(lax188)_downregulated
      WBPaper00058711:wdr-5(ok1417)_upregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059471:EGL-43_interacting
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_OP50
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060014:set-2(zr2012)_downregulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060084:cco-1(RNAi)_upregulated_N2
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(et18)_upregulated
      WBPaper00060951:mrpl-2(osa3)_downregulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:AVA
      WBPaper00061340:AVK
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:mu_sph
      WBPaper00061340:RIC
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:cfz-2_18944-cfz-2_2268
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065029:cadmium_upregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
      WBPaper00025032:cluster_10
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:hlh_1_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00034739:N2moreDR1350
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00056330:mrps-5(RNAi)_upregulated
      WBPaper00057098:SiO2-nanoparticles_upregulated
    SAGE_tag: SAGE:ccaaattgatgatgagt Strand: Sense
        Unambiguously_mapped
      SAGE:ccaaattgat Strand: Sense
        Unambiguously_mapped
      SAGE:tgtcacttttcttacca Strand: Sense
        Unambiguously_mapped
      SAGE:aaaacttgga Strand: Antisense
      SAGE:cattctaaaccaaatga Strand: Antisense
      SAGE:attgtaataactgcaca Strand: Antisense
      SAGE:ggtacagttgctgagct Strand: Sense
        Unambiguously_mapped
    Interaction (29)
    WBProcess: WBbiopr:00000012
  Map_info: Map: III Position: -0.74971 Error: 0.000513
    Positive: Positive_clone: F08F8 Person_evidence: WBPerson589
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4452
    Pseudo_map_position
  Reference (48)
  Remark: There are two kap-1 genes. The CGC_approved one is connected to F08F8.3a/b, the non_CGC_approved one (from the original GenBank/EMBL AF045926) is an other_name of aka-1 and is linked to D1022.7a/b/c [JAH][030120 ck1]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene