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WormBase Tree Display for Gene: WBGene00002177

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Name Class

WBGene00002177SMapS_parentSequenceF35C8
IdentityVersion1
NameCGC_namejkk-1
Sequence_nameF35C8.3
Molecular_nameF35C8.3
F35C8.3.1
CE24941
F35C8.3.2
Other_namesek-2
CELE_F35C8.3Accession_evidenceNDBBX284606
Public_namejkk-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classjkk
Allele (123)
Possibly_affected_byWBVar02158462
StrainWBStrain00024034
WBStrain00052747
RNASeq_FPKM (74)
GO_annotation (29)
Ortholog (32)
Paralog (25)
Structured_descriptionConcise_descriptionjkk-1 encodes a member of the MAP kinase kinase superfamily that affects synaptic vesicle localization and is required in type-D motor neurons for normal locomotion; can function in the Hog1 MAP kinase pathway I in yeast as an activator of JNK and is expressed in most neuronsPaper_evidenceWBPaper00003607
WBPaper00004889
WBPaper00005014
WBPaper00018908
Curator_confirmedWBPerson48
Date_last_updated09 Aug 2004 00:00:00
Automated_descriptionEnables JUN kinase kinase activity. Involved in hyperosmotic response and locomotion. Located in axon; cytoplasm; and neuronal cell body. Expressed in neurons. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K7 (mitogen-activated protein kinase kinase 7).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:3905Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6847)
DOID:3908Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6847)
DOID:8634Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6847)
DOID:3910Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6847)
DOID:234Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6847)
Molecular_infoCorresponding_CDSF35C8.3
Corresponding_transcriptF35C8.3.1
F35C8.3.2
Associated_featureWBsf648105
WBsf662781
WBsf662782
WBsf1005250
WBsf1005251
WBsf1022942
WBsf1022943
WBsf235713
WBsf235714
WBsf235715
Experimental_infoRNAi_resultWBRNAi00113189Inferred_automaticallyRNAi_primary
WBRNAi00046310Inferred_automaticallyRNAi_primary
WBRNAi00014313Inferred_automaticallyRNAi_primary
WBRNAi00069430Inferred_automaticallyRNAi_primary
WBRNAi00112959Inferred_automaticallyRNAi_primary
WBRNAi00028244Inferred_automaticallyRNAi_primary
WBRNAi00046315Inferred_automaticallyRNAi_primary
WBRNAi00094592Inferred_automaticallyRNAi_primary
WBRNAi00002050Inferred_automaticallyRNAi_primary
Expr_patternExpr1228
Expr11255
Expr1014081
Expr1031272
Expr1150198
Expr2012884
Expr2031118
Drives_constructWBCnstr00010164
WBCnstr00015940
WBCnstr00036408
Construct_productWBCnstr00000778
WBCnstr00010164
WBCnstr00018063
WBCnstr00018392
WBCnstr00036408
Microarray_results (26)
Expression_clusterWBPaper00024970:GABAergic_neuron_specific
WBPaper00032976:dosage_compensated_genes
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:BAG-neuron_embryo_enriched
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_embryo_enriched
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00038438:D.coniospora_12hr_upregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00040420:ALM_PLM_enriched
WBPaper00040420:FLP_enriched
WBPaper00044736:flat_dev_expression
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_tiling
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050370:dpy-21(e428)_L3_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053771:up_at_24h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056619:CEPsh_enriched
WBPaper00056826:hmc_biased
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058678:DAF-12_upregulated_PVD
WBPaper00058711:wdr-5(ok1417)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059728:5ug_cholesterol_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:AIA
WBPaper00061340:AIB
WBPaper00061340:AIM
WBPaper00061340:AIN
WBPaper00061340:AIY
WBPaper00061340:AIZ
WBPaper00061340:ALA
WBPaper00061340:ALM_BDU
WBPaper00061340:ALN
WBPaper00061340:AUA
WBPaper00061340:AVB
WBPaper00061340:AVE
WBPaper00061340:AVG
WBPaper00061340:AVJ
WBPaper00061340:BAG
WBPaper00061340:CEP
WBPaper00061340:DA
WBPaper00061340:DA_DB
WBPaper00061340:DB
WBPaper00061340:DD
WBPaper00061340:DVA
WBPaper00061340:DVC
WBPaper00061340:OLQ
WBPaper00061340:PVP
WBPaper00061340:RIA
WBPaper00061340:RIB
WBPaper00061340:RIC
WBPaper00061340:RIH
WBPaper00061340:RIM
WBPaper00061340:RIS
WBPaper00061340:RIV
WBPaper00061340:RMD
WBPaper00061340:RME
WBPaper00061340:SIA
WBPaper00061340:SIB
WBPaper00061340:SMB
WBPaper00061340:SMD
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061466:nath-10(icb102)_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:rab-28-jbts-14_9542
WBPaper00061527:syd-1_2945-unc-41_2170
WBPaper00061651:CAN_enriched
WBPaper00061651:RME_DV_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(syb385)_downregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064494:postdauer_downregulated_AWA
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065158:AFD_enriched
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065841:17_0
WBPaper00065841:55_0
WBPaper00065841:58_0
WBPaper00065841:58_1
WBPaper00065841:60_0
WBPaper00065841:65_0
WBPaper00065841:72_0
WBPaper00065841:109_0
WBPaper00065841:123_0
WBPaper00065841:124_0
WBPaper00065841:125_0
WBPaper00066110:Doxorubicin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4489_group_13
cgc4489_group_22
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Enriched_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Embryo_A_Class
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00030985:Serratia_marcesens_upregulated
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032165:differentially_expressed_with_age_medoid_2
WBPaper00034661:AgNPs_downregulated
WBPaper00034739:N2moreDR1350
WBPaper00036123:Atrazine_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042548:miRISC_enriched
WBPaper00057098:SiO2-nanoparticles_upregulated
Interaction (199)
WBProcessWBbiopr:00000052
Map_infoMapXPosition-5.40375Error0.023352
PositivePositive_cloneF35C8Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4449
4261
4780
Pseudo_map_position
Reference (54)
PictureWBPicture0000013081
Remarksequence and product from N Hisamoto
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene