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WormBase Tree Display for Variation: WBVar02158462

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Name Class

WBVar02158462Possibly_affectsWBGene00002177
DescriptionPhenotypeWBPhenotype:0000059Paper_evidenceWBPaper00065130
Curator_confirmedWBPerson712
RemarkThree amino acid substitutions, S274E, S278E and S280E were introduced to generate a potential phosphomimetic kinase mutant JKK-1(3E). JKK-1(3E) worms had an increased survival in L1 arrest (Figure 1D) and also had a higher chance to recover from the arrest upon addition of food and to develop to fertile adults compared to wild type (Figure 1E).Paper_evidenceWBPaper00065130
Curator_confirmedWBPerson712
WBPhenotype:0002522Paper_evidenceWBPaper00065130
Curator_confirmedWBPerson712
RemarkThree amino acid substitutions, S274E, S278E and S280E were introduced to generate a potential phosphomimetic kinase mutant JKK-1(3E). JKK-1(3E) worms had an increased survival in L1 arrest (Figure 1D) and also had a higher chance to recover from the arrest upon addition of food and to develop to fertile adults compared to wild type (Figure 1E).Paper_evidenceWBPaper00065130
Curator_confirmedWBPerson712
Phenotype_not_observedWBPhenotype:0000062Paper_evidenceWBPaper00065130
Curator_confirmedWBPerson712
RemarkThree amino acid substitutions, S274E, S278E and S280E were introduced to generate a potential phosphomimetic kinase mutant JKK-1(3E). Homozygous viable.Paper_evidenceWBPaper00065130
Curator_confirmedWBPerson712
ReferenceWBPaper00065130