WormBase Tree Display for Variation: WBVar02158462
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WBVar02158462 | Possibly_affects | WBGene00002177 | |||||
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Description | Phenotype | WBPhenotype:0000059 | Paper_evidence | WBPaper00065130 | |||
Curator_confirmed | WBPerson712 | ||||||
Remark | Three amino acid substitutions, S274E, S278E and S280E were introduced to generate a potential phosphomimetic kinase mutant JKK-1(3E). JKK-1(3E) worms had an increased survival in L1 arrest (Figure 1D) and also had a higher chance to recover from the arrest upon addition of food and to develop to fertile adults compared to wild type (Figure 1E). | Paper_evidence | WBPaper00065130 | ||||
Curator_confirmed | WBPerson712 | ||||||
WBPhenotype:0002522 | Paper_evidence | WBPaper00065130 | |||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Three amino acid substitutions, S274E, S278E and S280E were introduced to generate a potential phosphomimetic kinase mutant JKK-1(3E). JKK-1(3E) worms had an increased survival in L1 arrest (Figure 1D) and also had a higher chance to recover from the arrest upon addition of food and to develop to fertile adults compared to wild type (Figure 1E). | Paper_evidence | WBPaper00065130 | ||||
Curator_confirmed | WBPerson712 | ||||||
Phenotype_not_observed | WBPhenotype:0000062 | Paper_evidence | WBPaper00065130 | ||||
Curator_confirmed | WBPerson712 | ||||||
Remark | Three amino acid substitutions, S274E, S278E and S280E were introduced to generate a potential phosphomimetic kinase mutant JKK-1(3E). Homozygous viable. | Paper_evidence | WBPaper00065130 | ||||
Curator_confirmed | WBPerson712 | ||||||
Reference | WBPaper00065130 |