WormBase Tree Display for Gene: WBGene00002101
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| WBGene00002101 | Evidence | Paper_evidence | WBPaper00003189 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPaper00004209 | |||||||||
| WBPaper00004623 | |||||||||
| SMap | S_parent | Sequence | T28B8 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | ins-18 | Person_evidence | WBPerson339 | |||||
| Sequence_name | T28B8.2 | ||||||||
| Molecular_name | T28B8.2 | ||||||||
| T28B8.2.1 | |||||||||
| CE27217 | |||||||||
| Other_name | ins-1 | Accession_evidence | EMBL | AB008096 | |||||
| Ceinsulin-1 | |||||||||
| igf-1 | |||||||||
| CELE_T28B8.2 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | ins-18 | ||||||||
| DB_info | Database | AceView | gene | 1I725 | |||||
| WormQTL | gene | WBGene00002101 | |||||||
| SignaLink | protein | WBGene00002101 | |||||||
| WormFlux | gene | WBGene00002101 | |||||||
| NDB | locus_tag | CELE_T28B8.2 | |||||||
| NCBI | gene | 172600 | |||||||
| RefSeq | protein | NM_001392642.1 | |||||||
| TREEFAM | TREEFAM_ID | TF320519 | |||||||
| TrEMBL | UniProtAcc | G5ECC6 | |||||||
| UniProt_GCRP | UniProtAcc | G5ECC6 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | ins | ||||||||
| Allele (30) | |||||||||
| Legacy_information | [Ferguson K] ins for INSulin related. No mutants known. | ||||||||
| Strain | WBStrain00036424 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00011503 | ||||||||
| 00011504 | |||||||||
| 00011505 | |||||||||
| 00011506 | |||||||||
| 00011507 | |||||||||
| Ortholog (24) | |||||||||
| Paralog | WBGene00002100 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | ins-18 encodes one of 40 C. elegans insulin/IGF-like peptides; INS-18, along with INS-1, are the only two C. elegans insulins that contain a C peptide, characteristic of mammalian insulins, connecting the B and A chains; overexpression of ins-18 induces dauer arrest at 26 degrees C and enhances the dauer arrest seen in a daf-2 mutant at 20 degrees C, suggesting that INS-18 functions to antagonize DAF-2 receptor signaling; in addition, daf-7; ins-18 doubly mutant animals show dauer maintenance defects, suggesting that INS-18 activity is required to properly maintain the dauer developmental state; ins-18::gfp reporters are expressed in neurons and the intestine. | Paper_evidence | WBPaper00004209 | |||||
| WBPaper00004623 | |||||||||
| WBPaper00029214 | |||||||||
| WBPaper00031997 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 Aug 2008 00:00:00 | ||||||||
| Automated_description | Involved in maintenance of dauer; negative regulation of insulin receptor signaling pathway; and regulation of dauer entry. Expressed in several structures, including coelomocyte; gonad; head muscle; nerve ring; and neurons. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T28B8.2 | |||||||
| Corresponding_CDS_history | T28B8.2:wp47 | ||||||||
| Corresponding_transcript | T28B8.2.1 | ||||||||
| Other_sequence (13) | |||||||||
| Associated_feature | WBsf643515 | ||||||||
| WBsf984356 | |||||||||
| WBsf984357 | |||||||||
| WBsf1010193 | |||||||||
| WBsf218127 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028245 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00063197 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00092917 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063196 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00069854 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00004334 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00107963 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054383 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063818 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00013488 | ||||||||
| WBCnstr00015093 | |||||||||
| WBCnstr00017682 | |||||||||
| WBCnstr00017800 | |||||||||
| WBCnstr00021719 | |||||||||
| WBCnstr00036453 | |||||||||
| Construct_product | WBCnstr00015093 | ||||||||
| WBCnstr00019165 | |||||||||
| WBCnstr00019275 | |||||||||
| WBCnstr00036453 | |||||||||
| Antibody | WBAntibody00000292 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (155) | |||||||||
| Interaction (94) | |||||||||
| Map_info | Map | I | Position | 2.60082 | Error | 0.007891 | |||
| Positive | Positive_clone | T28B8 | Author_evidence | Ferguson KC | |||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Pseudo_map_position | |||||||||
| Reference (99) | |||||||||
| Remark | ins-1 is an EMBL gene name (not CGC-approved) and became an other-name of ins-18 as their protein sequences are identical. This unofficial ins-1 is not the same as the CGC ins-1 (F13B12.5) | Curator_confirmed | WBPerson1845 | ||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
