WormBase Tree Display for Gene: WBGene00002018
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| WBGene00002018 | SMap | S_parent | Sequence | Y46H3A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | hsp-16.41 | Person_evidence | WBPerson36 | |||||
| Sequence_name | Y46H3A.2 | ||||||||
| Molecular_name | Y46H3A.2 | ||||||||
| Y46H3A.2.1 | |||||||||
| CE22003 | |||||||||
| Other_name | hsp-16 | ||||||||
| CELE_Y46H3A.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | hsp-16.41 | ||||||||
| DB_info | Database | AceView | gene | 5C283 | |||||
| WormQTL | gene | WBGene00002018 | |||||||
| WormFlux | gene | WBGene00002018 | |||||||
| NDB | locus_tag | CELE_Y46H3A.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002018|UniProtKB=P06581 | |||||||
| family | PTHR45640 | ||||||||
| NCBI | gene | 178660 | |||||||
| RefSeq | protein | NM_182316.5 | |||||||
| SwissProt | UniProtAcc | P06581 | |||||||
| UniProt_GCRP | UniProtAcc | P06581 | |||||||
| OMIM | gene | 123580 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | hsp | ||||||||
| Allele (21) | |||||||||
| Strain (15) | |||||||||
| In_cluster | HSP16B | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (11) | |||||||||
| Ortholog (91) | |||||||||
| Paralog (17) | |||||||||
| Structured_description | Concise_description | hsp-16.41 encodes a 16-kD heat shock protein (HSP) that is a member of the hsp16/hsp20/alphaB-crystallin (HSP16) family of heat shock proteins; an hsp-16.41 reporter fusion, expressed broadly but strongest in intestine and pharynx, is induced in response to heat shock or other environmental stresses; expression is detectable in somatic tissues in post-gastrulation embryos, all larval stages, and in adults; HSP-16.41 is likely to function as a passive ligand temporarily preventing unfolded proteins from aggregating. | Paper_evidence | WBPaper00001187 | |||||
| WBPaper00001497 | |||||||||
| WBPaper00002665 | |||||||||
| WBPaper00004424 | |||||||||
| WBPaper00013029 | |||||||||
| WBPaper00013239 | |||||||||
| WBPaper00013280 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 05 Nov 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Predicted to be located in cytoplasm and nucleus. Expressed in several structures, including alimentary muscle; coelomocyte; intestine; neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110266 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2388) | ||||
| Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, the heat-shock transcription factor, after activation, induces the expression of other small heat shock proteins (sHSP); HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes; also, the sHSPs, HSP-16.1, HSP-16.41 and DNJ-19 are required for an acquired tolerance to heat stroke. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 29 May 2013 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y46H3A.2 | |||||||
| Corresponding_transcript | Y46H3A.2.1 | ||||||||
| Other_sequence (61) | |||||||||
| Associated_feature | WBsf646680 | ||||||||
| WBsf646681 | |||||||||
| WBsf919559 | |||||||||
| WBsf919560 | |||||||||
| WBsf919561 | |||||||||
| WBsf919562 | |||||||||
| WBsf231437 | |||||||||
| WBsf231438 | |||||||||
| WBsf231439 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00027603 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00056699 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00106383 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00070131 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00020673 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (11) | |||||||||
| Drives_construct (176) | |||||||||
| Construct_product | WBCnstr00010254 | ||||||||
| WBCnstr00010255 | |||||||||
| WBCnstr00017025 | |||||||||
| WBCnstr00036518 | |||||||||
| WBCnstr00042209 | |||||||||
| Antibody | WBAntibody00000051 | ||||||||
| WBAntibody00001859 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (413) | |||||||||
| Interaction (45) | |||||||||
| Map_info | Map | V | Position | -17.4232 | Error | 0.07866 | |||
| Positive | Positive_clone | Y46H3A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4418 | |||||||
| Pseudo_map_position | |||||||||
| Reference (69) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
