WormBase Tree Display for Gene: WBGene00002018

WBGene00002018 SMap: S_parent: Sequence: Y46H3A
  Identity: Version: 1
    Name: CGC_name: hsp-16.41 Person_evidence: WBPerson36
      Sequence_name: Y46H3A.2
      Molecular_name: Y46H3A.2
        Y46H3A.2.1
        CE22003
      Other_name: hsp-16
        CELE_Y46H3A.2 Accession_evidence: NDB BX284605
      Public_name: hsp-16.41
    DB_info: Database: AceView gene 5C283
        WormQTL gene WBGene00002018
        WormFlux gene WBGene00002018
        NDB locus_tag CELE_Y46H3A.2
        Panther gene CAEEL|WormBase=WBGene00002018|UniProtKB=P06581
          family PTHR45640
        NCBI gene 178660
        RefSeq protein NM_182316.5
        SwissProt UniProtAcc P06581
        UniProt_GCRP UniProtAcc P06581
        OMIM gene 123580
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:26 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (10)
  Disease_info: Potential_model: DOID:0110266 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2388)
    Disease_relevance: C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, the heat-shock transcription factor, after activation, induces the expression of other small heat shock proteins (sHSP); HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpresiion of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes; also, the sHSPs, HSP-16.1, HSP-16.41 and DNJ-19 are required for an acquired tolerance to heat stroke. Homo sapiens Paper_evidence: WBPaper00041564
          Curator_confirmed: WBPerson324
          Date_last_updated: 29 May 2013 00:00:00
  Molecular_info: Corresponding_CDS: Y46H3A.2
    Corresponding_transcript: Y46H3A.2.1
    Other_sequence (61)
    Associated_feature: WBsf646680
      WBsf646681
      WBsf919559
      WBsf919560
      WBsf919561
      WBsf919562
      WBsf231437
      WBsf231438
      WBsf231439
  Experimental_info: RNAi_result: WBRNAi00027603 Inferred_automatically: RNAi_primary
      WBRNAi00056699 Inferred_automatically: RNAi_primary
      WBRNAi00106383 Inferred_automatically: RNAi_primary
      WBRNAi00076794 Inferred_automatically: RNAi_primary
      WBRNAi00070131 Inferred_automatically: RNAi_primary
      WBRNAi00020673 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct (176)
    Construct_product: WBCnstr00010254
      WBCnstr00010255
      WBCnstr00017025
      WBCnstr00036518
      WBCnstr00042209
    Antibody: WBAntibody00000051
      WBAntibody00001859
    Microarray_results (17)
    Expression_cluster (413)
    Interaction (45)
  Map_info: Map: V Position: -17.4232 Error: 0.07866
    Positive: Positive_clone: Y46H3A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4418
    Pseudo_map_position
  Reference (69)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene